Bioactivity assessment of additively manufactured doped-HA composite scaffolds for bone tissue engineering

Swati Jindal; Cecile  Serenelli; Elena Mancuso

doi:10.18416/AMMM.2021.2109521

Bioactivity assessment of additively manufactured doped-HA composite scaffolds for bone tissue engineering

Swati Jindal, Cecile Serenelli, Elena Mancuso

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Abstract

Composites are promising candidates for treating bone defects, but manufacturing of composite scaffolds is challenging. This study aimed to fabricate composite scaffolds based on polycaprolactone (PCL) and doped Hydroxyapatite (HA) via a single step melt extrusion additive manufacturing technique. Starting from the raw powder forms, the printed scaffolds were produced and then characterized for morphology, mechanical behavior and in vitro mineralization. MicroCT revealed the homogenous dispersion of ceramic particles in the PCL matrix. Also, SEM showed the ceramic particles on the surfaces of printed scaffolds. Furthermore, bioactivity assays confirmed the enhanced apatite deposit formation on composite scaffolds compared to PCL alone.

Original language	English
Journal	Transactions on Additive Manufacturing Meets Medicine
Volume	3
Issue number	1
DOIs	https://doi.org/10.18416/AMMM.2021.2109521
Publication status	Published (in print/issue) - 8 Sept 2021
Event	AMMM - Additive Manufacturing Meets Medicine 2021 - Digital Conference Duration: 8 Sept 2021 → 10 Oct 2021 https://www.ammm.science/home

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10.18416/AMMM.2021.2109521Licence: CC BY

521-Short Paper-2676-1-10-20210817Final published version, 1.15 MBLicence: CC BY

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title = "Bioactivity assessment of additively manufactured doped-HA composite scaffolds for bone tissue engineering",

abstract = "Composites are promising candidates for treating bone defects, but manufacturing of composite scaffolds is challenging. This study aimed to fabricate composite scaffolds based on polycaprolactone (PCL) and doped Hydroxyapatite (HA) via a single step melt extrusion additive manufacturing technique. Starting from the raw powder forms, the printed scaffolds were produced and then characterized for morphology, mechanical behavior and in vitro mineralization. MicroCT revealed the homogenous dispersion of ceramic particles in the PCL matrix. Also, SEM showed the ceramic particles on the surfaces of printed scaffolds. Furthermore, bioactivity assays confirmed the enhanced apatite deposit formation on composite scaffolds compared to PCL alone.",

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T1 - Bioactivity assessment of additively manufactured doped-HA composite scaffolds for bone tissue engineering

AU - Jindal, Swati

AU - Serenelli, Cecile

AU - Mancuso, Elena

PY - 2021/9/8

Y1 - 2021/9/8

N2 - Composites are promising candidates for treating bone defects, but manufacturing of composite scaffolds is challenging. This study aimed to fabricate composite scaffolds based on polycaprolactone (PCL) and doped Hydroxyapatite (HA) via a single step melt extrusion additive manufacturing technique. Starting from the raw powder forms, the printed scaffolds were produced and then characterized for morphology, mechanical behavior and in vitro mineralization. MicroCT revealed the homogenous dispersion of ceramic particles in the PCL matrix. Also, SEM showed the ceramic particles on the surfaces of printed scaffolds. Furthermore, bioactivity assays confirmed the enhanced apatite deposit formation on composite scaffolds compared to PCL alone.

AB - Composites are promising candidates for treating bone defects, but manufacturing of composite scaffolds is challenging. This study aimed to fabricate composite scaffolds based on polycaprolactone (PCL) and doped Hydroxyapatite (HA) via a single step melt extrusion additive manufacturing technique. Starting from the raw powder forms, the printed scaffolds were produced and then characterized for morphology, mechanical behavior and in vitro mineralization. MicroCT revealed the homogenous dispersion of ceramic particles in the PCL matrix. Also, SEM showed the ceramic particles on the surfaces of printed scaffolds. Furthermore, bioactivity assays confirmed the enhanced apatite deposit formation on composite scaffolds compared to PCL alone.

U2 - 10.18416/AMMM.2021.2109521

DO - 10.18416/AMMM.2021.2109521

M3 - Conference article

SN - 2699-1977

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JO - Transactions on Additive Manufacturing Meets Medicine

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T2 - AMMM - Additive Manufacturing Meets Medicine 2021

Y2 - 8 September 2021 through 10 October 2021

ER -

Bioactivity assessment of additively manufactured doped-HA composite scaffolds for bone tissue engineering

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