Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1077-1084 |
| Journal | Gene Therapy |
| Volume | 20 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1 Nov 2013 |
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Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice. / Vasu, S; Moffett, RC; McCluskey, Janie; Hamid, MH; Irwin, Nigel; Flatt, Peter.
In: Gene Therapy, Vol. 20, No. 11, 01.11.2013, p. 1077-1084.Research output: Contribution to journal › Article
TY - JOUR
T1 - Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice
AU - Vasu, S
AU - Moffett, RC
AU - McCluskey, Janie
AU - Hamid, MH
AU - Irwin, Nigel
AU - Flatt, Peter
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Parenteral delivery of long-acting glucagon-like peptide-1 (GLP-1) mimetics has received much attention as a therapeutic option for diabetes. However, cell therapy-based GLP-1 treatments may provide a more physiological regulation of blood glucose. The present study assessed the effects of chronic GLP-1 delivery by cell therapy, using the GLP-1-secreting GLUTag cell line, in normoglycemic and streptozotocin-induced diabetic mice. GLUTag cell aggregates were transplanted into the subscapular region of mice. Over 30 days, cellular transplantation gave rise to encapsulated and well-vascularized growths, which contained immunoreactive GLP-1. Cell implantation was well tolerated and had no appreciable metabolic effects in normal mice. However, transplantation significantly (P
AB - Parenteral delivery of long-acting glucagon-like peptide-1 (GLP-1) mimetics has received much attention as a therapeutic option for diabetes. However, cell therapy-based GLP-1 treatments may provide a more physiological regulation of blood glucose. The present study assessed the effects of chronic GLP-1 delivery by cell therapy, using the GLP-1-secreting GLUTag cell line, in normoglycemic and streptozotocin-induced diabetic mice. GLUTag cell aggregates were transplanted into the subscapular region of mice. Over 30 days, cellular transplantation gave rise to encapsulated and well-vascularized growths, which contained immunoreactive GLP-1. Cell implantation was well tolerated and had no appreciable metabolic effects in normal mice. However, transplantation significantly (P
U2 - 10.1038/gt.2013.33
DO - 10.1038/gt.2013.33
M3 - Article
VL - 20
SP - 1077
EP - 1084
JO - Gene Therapy
JF - Gene Therapy
SN - 0969-7128
IS - 11
ER -