Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated A beta((1-42)) injections in the rat

RL Richardson, Eun-Mee Kim, RA Shephard, T Gardiner, J Cleary, E O'Hare

Research output: Contribution to journalArticle

Abstract

It has been suggested that inflammatory processes may play a role in the development of Alzheimer's disease (AD), and that nonsteroidal anti-inflammatory drug treatments may provide protection against the onset of AD. In the current study male Wistar rats were trained in two-lever operant chambers under an alternating lever cyclic-ratio ratio (ALCR) schedule. When responding showed no trends, subjects were divided into groups. One group was bilaterally injected into the CA3 area of the hippocampus with 5 mul of aggregated beta-amyloid (Abeta) suspension, and one group was bilaterally injected into the CA3 area of the hippocampus with 5 mul of sterile saline. Subgroups were treated twice daily with 0.1 ml (40 mg/kg) ibuprofen administered orally. The results indicated that chronic administration of ibuprofen protected against detrimental behavioural effects following aggregated Abeta injections. Withdrawal of ibuprofen treatment from aggregated Abeta-injected subjects produced a decline in behavioural performance to the level of the non-treated aggregated Abeta-injected group. Ibuprofen treatment reduced the numbers of reactive astrocytes following aggregated Abeta injection, and withdrawal of ibuprofen resulted in an increase of reactive astrocytes. These results suggest that induced inflammatory processes may play a role in AD, and that ibuprofen treatment may protect against some of the symptoms seen in AD. (C) 2002 Elsevier Science B.V. All rights reserved.
LanguageEnglish
Pages1-10
JournalBrain Research
Volume954
Issue number1
Publication statusPublished - Nov 2002

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Ibuprofen
Amyloid
Injections
Alzheimer Disease
Astrocytes
Hippocampus
Therapeutics
Wistar Rats
Suspensions
Appointments and Schedules
Anti-Inflammatory Agents
Pharmaceutical Preparations

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Richardson, RL ; Kim, Eun-Mee ; Shephard, RA ; Gardiner, T ; Cleary, J ; O'Hare, E. / Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated A beta((1-42)) injections in the rat. In: Brain Research. 2002 ; Vol. 954, No. 1. pp. 1-10.
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Richardson, RL, Kim, E-M, Shephard, RA, Gardiner, T, Cleary, J & O'Hare, E 2002, 'Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated A beta((1-42)) injections in the rat', Brain Research, vol. 954, no. 1, pp. 1-10.

Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated A beta((1-42)) injections in the rat. / Richardson, RL; Kim, Eun-Mee; Shephard, RA; Gardiner, T; Cleary, J; O'Hare, E.

In: Brain Research, Vol. 954, No. 1, 11.2002, p. 1-10.

Research output: Contribution to journalArticle

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AB - It has been suggested that inflammatory processes may play a role in the development of Alzheimer's disease (AD), and that nonsteroidal anti-inflammatory drug treatments may provide protection against the onset of AD. In the current study male Wistar rats were trained in two-lever operant chambers under an alternating lever cyclic-ratio ratio (ALCR) schedule. When responding showed no trends, subjects were divided into groups. One group was bilaterally injected into the CA3 area of the hippocampus with 5 mul of aggregated beta-amyloid (Abeta) suspension, and one group was bilaterally injected into the CA3 area of the hippocampus with 5 mul of sterile saline. Subgroups were treated twice daily with 0.1 ml (40 mg/kg) ibuprofen administered orally. The results indicated that chronic administration of ibuprofen protected against detrimental behavioural effects following aggregated Abeta injections. Withdrawal of ibuprofen treatment from aggregated Abeta-injected subjects produced a decline in behavioural performance to the level of the non-treated aggregated Abeta-injected group. Ibuprofen treatment reduced the numbers of reactive astrocytes following aggregated Abeta injection, and withdrawal of ibuprofen resulted in an increase of reactive astrocytes. These results suggest that induced inflammatory processes may play a role in AD, and that ibuprofen treatment may protect against some of the symptoms seen in AD. (C) 2002 Elsevier Science B.V. All rights reserved.

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