Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study

N Meunier, JH Beattie, D Ciarapica, JM O'Connor, M Andriollo-Sanchez, A Taras, C Coudray, A Polito

Research output: Contribution to journalArticle

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Abstract

Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10%, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.
LanguageEnglish
PagesS53-S57
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue numberSuppl.
DOIs
Publication statusPublished - Nov 2005

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Basal Metabolism
Thyroid Hormones
Volunteers
France
Fats
Body Composition
Italy
Zinc
Northern Ireland
Skinfold Thickness
Indirect Calorimetry
Triiodothyronine
Luminescence
Thyroxine
Immunoassay
Erythrocytes
Prospective Studies
Population

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Meunier, N., Beattie, JH., Ciarapica, D., O'Connor, JM., Andriollo-Sanchez, M., Taras, A., ... Polito, A. (2005). Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. European Journal of Clinical Nutrition, 59(Suppl.), S53-S57. https://doi.org/10.1038/sj.ejcn.1602299
Meunier, N ; Beattie, JH ; Ciarapica, D ; O'Connor, JM ; Andriollo-Sanchez, M ; Taras, A ; Coudray, C ; Polito, A. / Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. In: European Journal of Clinical Nutrition. 2005 ; Vol. 59, No. Suppl. pp. S53-S57.
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abstract = "Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7{\%} P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12{\%}). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10{\%}, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.",
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Meunier, N, Beattie, JH, Ciarapica, D, O'Connor, JM, Andriollo-Sanchez, M, Taras, A, Coudray, C & Polito, A 2005, 'Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study', European Journal of Clinical Nutrition, vol. 59, no. Suppl., pp. S53-S57. https://doi.org/10.1038/sj.ejcn.1602299

Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study. / Meunier, N; Beattie, JH; Ciarapica, D; O'Connor, JM; Andriollo-Sanchez, M; Taras, A; Coudray, C; Polito, A.

In: European Journal of Clinical Nutrition, Vol. 59, No. Suppl., 11.2005, p. S53-S57.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study

AU - Meunier, N

AU - Beattie, JH

AU - Ciarapica, D

AU - O'Connor, JM

AU - Andriollo-Sanchez, M

AU - Taras, A

AU - Coudray, C

AU - Polito, A

PY - 2005/11

Y1 - 2005/11

N2 - Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10%, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

AB - Objective: This paper describes baseline data on basal metabolic rate (BMR), thyroid hormone levels and body composition of middle-aged and older people participating in the ZENITH project and the correlation of thyroid hormone levels with zinc status. Design: A multicentre prospective intervention study employing a randomised double blind design. Setting: Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France), Rome (Italy). Interventions: BMR has been measured on a subsample of 70 middle-aged volunteers (35 men and 35 women recruited in Clermont-Ferrand, France, aged 55-70 y) and 108 older volunteers (56 men and 52 women recruited in Rome, Italy, aged 70-85 y). Thyroid hormone levels were evaluated in the entire group of ZENITH volunteers (n = 387). BMR was measured by indirect calorimetry. Fat-free mass (FFM) was derived by four skinfold thicknesses using Durnin and Womersley's equations. Concentrations of thyroid hormones (total T3 and T4) were measured using a competitive immunoassay with an enhanced chemiluminescence end point. Results: Italian older volunteers had a significantly lower FFM than middle-aged French volunteers (-7% P<0.01). A negative correlation between BMR and age (men, r= -0.64; women, r= -0.62; both P<0.0001) was observed: BMR was significantly (P<0.000001) lower in Italian elderly volunteers (4.03 +/- 0.46 kJ/min and 3.29 +/- 0.42 kJ/min for men and women, respectively) than in middle-aged French volunteers (4.84 +/- 0.45 kJ/min and 3.87 +/- 0.38 kJ/min for men and women, respectively), even after adjustment for FFM (-12%). No correlation has been observed between BMR and thyroid hormones both in French and Italian subjects. Total T4 (T-174) concentrations were lowest in middle-aged population (-10%, P<0.0001). A moderate negative correlation has been found with TT4 and red blood cell zinc (r= -0.12, P<0.02, slope -0.026). Conclusions: The results confirm an age-related decline in BMR not entirely explained by body composition or thyroid hormones differences.

U2 - 10.1038/sj.ejcn.1602299

DO - 10.1038/sj.ejcn.1602299

M3 - Article

VL - 59

SP - S53-S57

JO - European Journal of Clinical Nutrition

T2 - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - Suppl.

ER -