Bariatric Surgery in Women with Polycystic Ovary Syndrome

Suhaniya N S Samarasinghe; Casper Woods; Alexander Dimitri Miras

doi:10.1016/j.metabol.2023.155745

Bariatric Surgery in Women with Polycystic Ovary Syndrome

Suhaniya N S Samarasinghe
, Casper Woods
, Alexander Dimitri Miras

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

135 Downloads (Pure)

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. Bariatric surgery is still an experimental treatment in women with PCOS and subfertility. This review will present an overview of the pathophysiology of PCOS and obesity and the role of bariatric surgery. Although data are sparse regarding the impact of bariatric surgery on subfertility in women with PCOS and obesity, existing studies point to a beneficial role in treating metabolic and reproductive dysfunction. [Abstract copyright: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.]

Original language	English
Article number	155745
Pages (from-to)	1-11
Number of pages	11
Journal	Metabolism: Clinical and Experimental
Volume	151
Early online date	27 Nov 2023
DOIs	https://doi.org/10.1016/j.metabol.2023.155745
Publication status	Published (in print/issue) - 29 Feb 2024

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Funding

Funding Information: The Section of Endocrinology and Investigative Medicine is funded by grants from the MRC , BBSRC , NIHR and is supported by the NIHR Biomedical Research Centre Funding Scheme. Alexander D. Miras has received research funding from the MRC , NIHR , Jon Moulton Charity Trust , Fractyl , Novo Nordisk and Randox . Publisher Copyright: © 2023 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Obesity
Fertility
Metabolic syndrome
Bariatric surgery
Polycystic ovary syndrome

Access to Document

10.1016/j.metabol.2023.155745

PIIS0026049523003499Final published version, 1.98 MBLicence: CC BY-NC-ND

Cite this

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title = "Bariatric Surgery in Women with Polycystic Ovary Syndrome",

abstract = "Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. Bariatric surgery is still an experimental treatment in women with PCOS and subfertility. This review will present an overview of the pathophysiology of PCOS and obesity and the role of bariatric surgery. Although data are sparse regarding the impact of bariatric surgery on subfertility in women with PCOS and obesity, existing studies point to a beneficial role in treating metabolic and reproductive dysfunction. [Abstract copyright: Copyright {\textcopyright} 2023 The Authors. Published by Elsevier Inc. All rights reserved.]",

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doi = "10.1016/j.metabol.2023.155745",

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T1 - Bariatric Surgery in Women with Polycystic Ovary Syndrome

AU - Samarasinghe, Suhaniya N S

AU - Woods, Casper

AU - Miras, Alexander Dimitri

PY - 2024/2/29

Y1 - 2024/2/29

N2 - Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. Bariatric surgery is still an experimental treatment in women with PCOS and subfertility. This review will present an overview of the pathophysiology of PCOS and obesity and the role of bariatric surgery. Although data are sparse regarding the impact of bariatric surgery on subfertility in women with PCOS and obesity, existing studies point to a beneficial role in treating metabolic and reproductive dysfunction. [Abstract copyright: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.]

AB - Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. Bariatric surgery is still an experimental treatment in women with PCOS and subfertility. This review will present an overview of the pathophysiology of PCOS and obesity and the role of bariatric surgery. Although data are sparse regarding the impact of bariatric surgery on subfertility in women with PCOS and obesity, existing studies point to a beneficial role in treating metabolic and reproductive dysfunction. [Abstract copyright: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.]

KW - Obesity

KW - Fertility

KW - Metabolic syndrome

KW - Bariatric surgery

KW - Polycystic ovary syndrome

UR - https://www.scopus.com/pages/publications/85178582797

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DO - 10.1016/j.metabol.2023.155745

M3 - Article

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SN - 0026-0495

VL - 151

SP - 1

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JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

M1 - 155745

ER -

Bariatric Surgery in Women with Polycystic Ovary Syndrome

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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