Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant proportion of women with PCOS and is strongly implicated in the pathophysiology of the disease. Both PCOS and obesity are known to impact fertility in women; obesity also reduces the success of assisted reproductive technology (ART). With or without pharmacotherapy, lifestyle intervention remains the first-line treatment in women with PCOS and obesity. Bariatric surgery is still an experimental treatment in women with PCOS and subfertility. This review will present an overview of the pathophysiology of PCOS and obesity and the role of bariatric surgery. Although data are sparse regarding the impact of bariatric surgery on subfertility in women with PCOS and obesity, existing studies point to a beneficial role in treating metabolic and reproductive dysfunction. [Abstract copyright: Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.]
| Original language | English |
|---|---|
| Article number | 155745 |
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Metabolism: Clinical and Experimental |
| Volume | 151 |
| Early online date | 27 Nov 2023 |
| DOIs | |
| Publication status | Published (in print/issue) - 29 Feb 2024 |
Bibliographical note
Publisher Copyright:© 2023 The Authors
Keywords
- Obesity
- Fertility
- Metabolic syndrome
- Bariatric surgery
- Polycystic ovary syndrome
