B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and Hypertension

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18 Citations (Scopus)


Hypertension is a leading risk factor for cardiovascular disease (CVD) and stroke. A common polymorphism in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR), previously identified as the main genetic determinant of elevated homocysteine concentration and also recognized as a risk factor for CVD, appears to be independently associated with hypertension. The B-vitamin riboflavin is required as a cofactor by MTHFR and recent evidence suggests it may have a role in modulating blood pressure, specifically in those with the homozygous mutant MTHFR 677 TT genotype. If studies confirm that this genetic predisposition to hypertension is correctable by low-dose riboflavin, the findings could have important implications for the management of hypertension given that the frequency of this polymorphism ranges from 3 to 32 % worldwide.

Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalInternational Journal of Vitamin Nutrition Research
Issue number4
Early online date31 Jul 2011
Publication statusPublished (in print/issue) - 7 Jan 2013


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