TY - JOUR
T1 - Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne
AU - Bisht, Alpna
AU - Hemrajani, Chetna
AU - Upadhyay, Navneet
AU - Nidhi, Prakriti
AU - Rolta, Rajan
AU - Rathore, Charul
AU - Gupta, Gaurav
AU - Dua, Kamal
AU - Chellappan, Dinesh Kumar
AU - Dev, Kamal
AU - Sourirajan, Anuradha
AU - Aljabali, Alaa Aa
AU - Bakshi, Hamid A
AU - Negi, Poonam
AU - Tambuwala, Murtaza M
N1 - Publisher Copyright:
© 2021 The Authors.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.
AB - Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.
KW - P. acne
KW - agar well diffusion method
KW - azelaic acid
KW - broth microdilution assay
KW - ethosomes
KW - skin permeation
UR - http://www.scopus.com/inward/record.url?scp=85124443831&partnerID=8YFLogxK
U2 - 10.4155/tde-2021-0059
DO - 10.4155/tde-2021-0059
M3 - Article
C2 - 34842461
SN - 2041-5990
VL - 13
SP - 13
EP - 29
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 1
ER -