Azelaic acid and Melaleuca alternifolia essential oil co-loaded vesicular carrier for combinational therapy of acne

Alpna Bisht, Chetna Hemrajani, Navneet Upadhyay, Prakriti Nidhi, Rajan Rolta, Charul Rathore, Gaurav Gupta, Kamal Dua, Dinesh Kumar Chellappan, Kamal Dev, Anuradha Sourirajan, Alaa Aa Aljabali, Hamid A Bakshi, Poonam Negi, Murtaza M Tambuwala

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    Abstract

    Aim: Azelaic acid (AzA), a comedolytic, antibacterial, anti-inflammatory anti-melanogenic agent, prescribed against acne vulgaris is safe on skin. Its combination with another widely used anti-acne agent, tea tree oil (EO) whose delivery is limited by volatility, instability and lipophilicity constraints was attempted. Method: Solvent injection was used to prepare AzA-EO integrated ethosomes. Result: Ethosomes were transformed into carbopol hydrogel, which exhibited pseudo-plastic properties with appreciable firmness, work of shear, stickiness and work of adhesion. The hydrogel showed better permeation and retention characteristics vis-a-vis commercial formulation (AzidermTM), when evaluated in Wistar rat skin. Further, ethosome hydrogel composite was better tolerated with no side effects. Conclusion: The findings suggests that the aforementioned strategy could be a potential treatment used for acne management.
    Original languageEnglish
    Number of pages17
    JournalTherapeutic Delivery
    DOIs
    Publication statusPublished - 29 Nov 2021

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