Autoimmunity roots of the thrombotic events after COVID-19 vaccination

Fatma Elrashdy; Murtaza M Tambuwala; Sk Sarif Hassan; Parise Adadi; Murat Seyran; Tarek Mohamed Abd El-Aziz; Nima Rezaei; Amos Lal; Alaa A A Aljabali; Ramesh Kandimalla; Nicolas G Bazan; Gajendra Kumar Azad; Samendra P Sherchan; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Kazuo Takayama; Gaurav Chauhan; Damiano Pizzol; Debmalya Barh; Pritam Kumar Panda; Yogendra K Mishra; Giorgio Palù; Kenneth Lundstrom; Elrashdy M Redwan; Vladimir N Uversky

doi:10.1016/j.autrev.2021.102941

Autoimmunity roots of the thrombotic events after COVID-19 vaccination

Fatma Elrashdy, Murtaza M Tambuwala, Sk Sarif Hassan, Parise Adadi, Murat Seyran, Tarek Mohamed Abd El-Aziz, Nima Rezaei, Amos Lal, Alaa A A Aljabali, Ramesh Kandimalla, Nicolas G Bazan, Gajendra Kumar Azad, Samendra P Sherchan, Pabitra Pal Choudhury, Ángel Serrano-Aroca, Kazuo Takayama, Gaurav Chauhan, Damiano Pizzol, Debmalya Barh, Pritam Kumar PandaYogendra K Mishra, Giorgio Palù, Kenneth Lundstrom, Elrashdy M Redwan, Vladimir N Uversky

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Abstract

Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.

Original language	English
Article number	102941
Number of pages	19
Journal	Autoimmunity Reviews
Volume	20
Issue number	11
Early online date	9 Sept 2021
DOIs	https://doi.org/10.1016/j.autrev.2021.102941
Publication status	Published (in print/issue) - 30 Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

Autoimmune Reaction
Adenoviral Vector-based Vaccine
Covid-19
Lipid Nanoparticle-Mrna-Based Vaccine
Vaccine-Induced Immune Thrombotic Thrombocytopenia
Autoimmunity
Vaccination/adverse effects
Humans
COVID-19
SARS Virus
SARS-CoV-2
COVID-19 Vaccines
Viral Vaccines
Lipid nanoparticle-mRNA-based vaccine
Adenoviral vector-based vaccine
Autoimmune reaction
Vaccine-induced immune thrombotic thrombocytopenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Elrashdy, F., Tambuwala, M. M., Hassan, S. S., Adadi, P., Seyran, M., Abd El-Aziz, T. M., Rezaei, N., Lal, A., Aljabali, A. A. A., Kandimalla, R., Bazan, N. G., Azad, G. K., Sherchan, S. P., Choudhury, P. P., Serrano-Aroca, Á., Takayama, K., Chauhan, G., Pizzol, D., Barh, D., ... Uversky, V. N. (2021). Autoimmunity roots of the thrombotic events after COVID-19 vaccination. Autoimmunity Reviews, 20(11), Article 102941. https://doi.org/10.1016/j.autrev.2021.102941

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title = "Autoimmunity roots of the thrombotic events after COVID-19 vaccination",

abstract = "Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.",

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author = "Fatma Elrashdy and Tambuwala, {Murtaza M} and Hassan, {Sk Sarif} and Parise Adadi and Murat Seyran and {Abd El-Aziz}, {Tarek Mohamed} and Nima Rezaei and Amos Lal and Aljabali, {Alaa A A} and Ramesh Kandimalla and Bazan, {Nicolas G} and Azad, {Gajendra Kumar} and Sherchan, {Samendra P} and Choudhury, {Pabitra Pal} and {\'A}ngel Serrano-Aroca and Kazuo Takayama and Gaurav Chauhan and Damiano Pizzol and Debmalya Barh and Panda, {Pritam Kumar} and Mishra, {Yogendra K} and Giorgio Pal{\`u} and Kenneth Lundstrom and Redwan, {Elrashdy M} and Uversky, {Vladimir N}",

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year = "2021",

month = nov,

day = "30",

doi = "10.1016/j.autrev.2021.102941",

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Elrashdy, F, Tambuwala, MM, Hassan, SS, Adadi, P, Seyran, M, Abd El-Aziz, TM, Rezaei, N, Lal, A, Aljabali, AAA, Kandimalla, R, Bazan, NG, Azad, GK, Sherchan, SP, Choudhury, PP, Serrano-Aroca, Á, Takayama, K, Chauhan, G, Pizzol, D, Barh, D, Panda, PK, Mishra, YK, Palù, G, Lundstrom, K, Redwan, EM & Uversky, VN 2021, 'Autoimmunity roots of the thrombotic events after COVID-19 vaccination', Autoimmunity Reviews, vol. 20, no. 11, 102941. https://doi.org/10.1016/j.autrev.2021.102941

TY - JOUR

T1 - Autoimmunity roots of the thrombotic events after COVID-19 vaccination

AU - Elrashdy, Fatma

AU - Tambuwala, Murtaza M

AU - Hassan, Sk Sarif

AU - Adadi, Parise

AU - Seyran, Murat

AU - Abd El-Aziz, Tarek Mohamed

AU - Rezaei, Nima

AU - Lal, Amos

AU - Aljabali, Alaa A A

AU - Kandimalla, Ramesh

AU - Bazan, Nicolas G

AU - Azad, Gajendra Kumar

AU - Sherchan, Samendra P

AU - Choudhury, Pabitra Pal

AU - Serrano-Aroca, Ángel

AU - Takayama, Kazuo

AU - Chauhan, Gaurav

AU - Pizzol, Damiano

AU - Barh, Debmalya

AU - Panda, Pritam Kumar

AU - Mishra, Yogendra K

AU - Palù, Giorgio

AU - Lundstrom, Kenneth

AU - Redwan, Elrashdy M

AU - Uversky, Vladimir N

PY - 2021/11/30

Y1 - 2021/11/30

N2 - Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.

AB - Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition.

KW - Autoimmune Reaction

KW - Adenoviral Vector-based Vaccine

KW - Covid-19

KW - Lipid Nanoparticle-Mrna-Based Vaccine

KW - Vaccine-Induced Immune Thrombotic Thrombocytopenia

KW - Autoimmunity

KW - Vaccination/adverse effects

KW - Humans

KW - COVID-19

KW - SARS Virus

KW - SARS-CoV-2

KW - COVID-19 Vaccines

KW - Viral Vaccines

KW - Lipid nanoparticle-mRNA-based vaccine

KW - Adenoviral vector-based vaccine

KW - Autoimmune reaction

KW - Vaccine-induced immune thrombotic thrombocytopenia

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U2 - 10.1016/j.autrev.2021.102941

DO - 10.1016/j.autrev.2021.102941

M3 - Review article

C2 - 34508917

SN - 1568-9972

VL - 20

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 11

M1 - 102941

ER -

Autoimmunity roots of the thrombotic events after COVID-19 vaccination

Abstract

Bibliographical note

Keywords

UN SDGs

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