Atheroprotective effects of (poly) phenols: a focus on cell cholesterol metabolism

Ilaria Zanotti, Margherita Dall'Asta, Pedro Mena, Laura Mele, Renato Bruni, Sumantra Ray, Daniele Del Rio

    Research output: Contribution to journalArticlepeer-review

    123 Citations (Scopus)


    Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.
    Original languageEnglish
    Pages (from-to)13-31
    Number of pages19
    JournalFood and Function
    Issue number1
    Early online date15 Oct 2014
    Publication statusPublished (in print/issue) - 1 Jan 2015


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