Atheroprotective effects of (poly) phenols: a focus on cell cholesterol metabolism

Ilaria Zanotti; Margherita Dall'Asta; Pedro Mena; Laura Mele; Renato Bruni; Sumantra Ray; Daniele Del Rio

doi:10.1039/c4fo00670d

Atheroprotective effects of (poly) phenols: a focus on cell cholesterol metabolism

Ilaria Zanotti, Margherita Dall'Asta, Pedro Mena, Laura Mele, Renato Bruni, Sumantra Ray, Daniele Del Rio

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99 Citations (Scopus)

Abstract

Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.

Original language	English
Pages (from-to)	13-31
Number of pages	19
Journal	Food and Function
Volume	6
Issue number	1
Early online date	15 Oct 2014
DOIs	https://doi.org/10.1039/c4fo00670d
Publication status	Published - 1 Jan 2015

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abstract = "Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.",

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AU - Bruni, Renato

AU - Ray, Sumantra

AU - Del Rio, Daniele

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AB - Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.

UR - https://pure.ulster.ac.uk/en/publications/atheroprotective-effects-of-poly-phenols-a-focus-on-cell-choleste

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Atheroprotective effects of (poly) phenols: a focus on cell cholesterol metabolism

Abstract

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