Atheroprotective effects of (poly) phenols: a focus on cell cholesterol metabolism

Ilaria Zanotti, Margherita Dall'Asta, Pedro Mena, Laura Mele, Renato Bruni, Sumantra Ray, Daniele Del Rio

Research output: Contribution to journalArticlepeer-review

139 Citations (Scopus)

Abstract

Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.
Original languageEnglish
Pages (from-to)13-31
Number of pages19
JournalFood and Function
Volume6
Issue number1
Early online date15 Oct 2014
DOIs
Publication statusPublished (in print/issue) - 1 Jan 2015

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