Asthma medication prescribing before, during and after pregnancy: a study in seven European regions

Rachel Charlton, Anna Pierini, Kari Klungsoyr, Amanda Neville, Susan Jordan, Lolkje de Jong-van den Berg, Daniel Thayer, H Jens Bos, Aurora Puccini, Anne V Hansen, Rosa Gini, Anders Engeland, Anne-Marie Nybo Andersen, Helen Dolk, Ester Garne

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Objectives To explore utilisation patterns of asthma medication before, during and after pregnancy as recorded in seven European population-based databases.Design A descriptive drug utilisation study.Setting 7 electronic healthcare databases in Denmark, Norway, the Netherlands, Italy (Emilia Romagna and Tuscany), Wales, and the Clinical Practice Research Datalink representing the rest of the UK.Participants All women with a pregnancy ending in a delivery that started and ended between 2004 and 2010, who had been present in the database for the year before, throughout and the year following pregnancy.Main outcome measures The percentage of deliveries where the woman received an asthma medicine prescription, based on prescriptions issued (UK) or dispensed (non-UK), during the year before, throughout or during the year following pregnancy. Asthma medicine prescribing patterns were described for 3-month time periods and the choice of asthma medicine and changes in prescribing over the study period were evaluated in each database.Results In total, 1 165 435 deliveries were identified. The prevalence of asthma medication prescribing during pregnancy was highest in the UK and Wales databases (9.4% (CI95 9.3% to 9.6%) and 9.4% (CI95 9.1% to 9.6%), respectively) and lowest in the Norwegian database (3.7% (CI95 3.7% to 3.8%)). In the year before pregnancy, the prevalence of asthma medication prescribing remained constant in all regions. Prescribing levels peaked during the second trimester of pregnancy and were at their lowest during the 3-month period following delivery. A decline was observed, in all regions except the UK, in the prescribing of long-acting β-2-agonists during pregnancy. During the 7-year study period, there were only small changes in prescribing patterns.Conclusions Differences were found in the prevalence of prescribing of asthma medications during and surrounding pregnancy in Europe. Inhaled β-2 agonists and inhaled corticosteroids were, however, the most popular therapeutic regimens in all databases.
    LanguageEnglish
    Pages0-0
    JournalBMJ Open
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2016

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    Asthma
    Pregnancy
    Databases
    Wales
    Medicine
    Prescriptions
    Drug Utilization
    Second Pregnancy Trimester
    Denmark
    Norway
    Netherlands
    Italy
    Adrenal Cortex Hormones
    Outcome Assessment (Health Care)
    Delivery of Health Care
    Research
    Population

    Keywords

    • EUROmediCAT

    Cite this

    Charlton, R., Pierini, A., Klungsoyr, K., Neville, A., Jordan, S., de Jong-van den Berg, L., ... Garne, E. (2016). Asthma medication prescribing before, during and after pregnancy: a study in seven European regions. BMJ Open, 6(1), 0-0. https://doi.org/10.1136/bmjopen-2015-009237
    Charlton, Rachel ; Pierini, Anna ; Klungsoyr, Kari ; Neville, Amanda ; Jordan, Susan ; de Jong-van den Berg, Lolkje ; Thayer, Daniel ; Bos, H Jens ; Puccini, Aurora ; Hansen, Anne V ; Gini, Rosa ; Engeland, Anders ; Nybo Andersen, Anne-Marie ; Dolk, Helen ; Garne, Ester. / Asthma medication prescribing before, during and after pregnancy: a study in seven European regions. In: BMJ Open. 2016 ; Vol. 6, No. 1. pp. 0-0.
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    abstract = "Objectives To explore utilisation patterns of asthma medication before, during and after pregnancy as recorded in seven European population-based databases.Design A descriptive drug utilisation study.Setting 7 electronic healthcare databases in Denmark, Norway, the Netherlands, Italy (Emilia Romagna and Tuscany), Wales, and the Clinical Practice Research Datalink representing the rest of the UK.Participants All women with a pregnancy ending in a delivery that started and ended between 2004 and 2010, who had been present in the database for the year before, throughout and the year following pregnancy.Main outcome measures The percentage of deliveries where the woman received an asthma medicine prescription, based on prescriptions issued (UK) or dispensed (non-UK), during the year before, throughout or during the year following pregnancy. Asthma medicine prescribing patterns were described for 3-month time periods and the choice of asthma medicine and changes in prescribing over the study period were evaluated in each database.Results In total, 1 165 435 deliveries were identified. The prevalence of asthma medication prescribing during pregnancy was highest in the UK and Wales databases (9.4{\%} (CI95 9.3{\%} to 9.6{\%}) and 9.4{\%} (CI95 9.1{\%} to 9.6{\%}), respectively) and lowest in the Norwegian database (3.7{\%} (CI95 3.7{\%} to 3.8{\%})). In the year before pregnancy, the prevalence of asthma medication prescribing remained constant in all regions. Prescribing levels peaked during the second trimester of pregnancy and were at their lowest during the 3-month period following delivery. A decline was observed, in all regions except the UK, in the prescribing of long-acting β-2-agonists during pregnancy. During the 7-year study period, there were only small changes in prescribing patterns.Conclusions Differences were found in the prevalence of prescribing of asthma medications during and surrounding pregnancy in Europe. Inhaled β-2 agonists and inhaled corticosteroids were, however, the most popular therapeutic regimens in all databases.",
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    Charlton, R, Pierini, A, Klungsoyr, K, Neville, A, Jordan, S, de Jong-van den Berg, L, Thayer, D, Bos, HJ, Puccini, A, Hansen, AV, Gini, R, Engeland, A, Nybo Andersen, A-M, Dolk, H & Garne, E 2016, 'Asthma medication prescribing before, during and after pregnancy: a study in seven European regions', BMJ Open, vol. 6, no. 1, pp. 0-0. https://doi.org/10.1136/bmjopen-2015-009237

    Asthma medication prescribing before, during and after pregnancy: a study in seven European regions. / Charlton, Rachel; Pierini, Anna; Klungsoyr, Kari; Neville, Amanda; Jordan, Susan; de Jong-van den Berg, Lolkje; Thayer, Daniel; Bos, H Jens; Puccini, Aurora; Hansen, Anne V; Gini, Rosa; Engeland, Anders; Nybo Andersen, Anne-Marie; Dolk, Helen; Garne, Ester.

    In: BMJ Open, Vol. 6, No. 1, 01.01.2016, p. 0-0.

    Research output: Contribution to journalArticle

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    T1 - Asthma medication prescribing before, during and after pregnancy: a study in seven European regions

    AU - Charlton, Rachel

    AU - Pierini, Anna

    AU - Klungsoyr, Kari

    AU - Neville, Amanda

    AU - Jordan, Susan

    AU - de Jong-van den Berg, Lolkje

    AU - Thayer, Daniel

    AU - Bos, H Jens

    AU - Puccini, Aurora

    AU - Hansen, Anne V

    AU - Gini, Rosa

    AU - Engeland, Anders

    AU - Nybo Andersen, Anne-Marie

    AU - Dolk, Helen

    AU - Garne, Ester

    PY - 2016/1/1

    Y1 - 2016/1/1

    N2 - Objectives To explore utilisation patterns of asthma medication before, during and after pregnancy as recorded in seven European population-based databases.Design A descriptive drug utilisation study.Setting 7 electronic healthcare databases in Denmark, Norway, the Netherlands, Italy (Emilia Romagna and Tuscany), Wales, and the Clinical Practice Research Datalink representing the rest of the UK.Participants All women with a pregnancy ending in a delivery that started and ended between 2004 and 2010, who had been present in the database for the year before, throughout and the year following pregnancy.Main outcome measures The percentage of deliveries where the woman received an asthma medicine prescription, based on prescriptions issued (UK) or dispensed (non-UK), during the year before, throughout or during the year following pregnancy. Asthma medicine prescribing patterns were described for 3-month time periods and the choice of asthma medicine and changes in prescribing over the study period were evaluated in each database.Results In total, 1 165 435 deliveries were identified. The prevalence of asthma medication prescribing during pregnancy was highest in the UK and Wales databases (9.4% (CI95 9.3% to 9.6%) and 9.4% (CI95 9.1% to 9.6%), respectively) and lowest in the Norwegian database (3.7% (CI95 3.7% to 3.8%)). In the year before pregnancy, the prevalence of asthma medication prescribing remained constant in all regions. Prescribing levels peaked during the second trimester of pregnancy and were at their lowest during the 3-month period following delivery. A decline was observed, in all regions except the UK, in the prescribing of long-acting β-2-agonists during pregnancy. During the 7-year study period, there were only small changes in prescribing patterns.Conclusions Differences were found in the prevalence of prescribing of asthma medications during and surrounding pregnancy in Europe. Inhaled β-2 agonists and inhaled corticosteroids were, however, the most popular therapeutic regimens in all databases.

    AB - Objectives To explore utilisation patterns of asthma medication before, during and after pregnancy as recorded in seven European population-based databases.Design A descriptive drug utilisation study.Setting 7 electronic healthcare databases in Denmark, Norway, the Netherlands, Italy (Emilia Romagna and Tuscany), Wales, and the Clinical Practice Research Datalink representing the rest of the UK.Participants All women with a pregnancy ending in a delivery that started and ended between 2004 and 2010, who had been present in the database for the year before, throughout and the year following pregnancy.Main outcome measures The percentage of deliveries where the woman received an asthma medicine prescription, based on prescriptions issued (UK) or dispensed (non-UK), during the year before, throughout or during the year following pregnancy. Asthma medicine prescribing patterns were described for 3-month time periods and the choice of asthma medicine and changes in prescribing over the study period were evaluated in each database.Results In total, 1 165 435 deliveries were identified. The prevalence of asthma medication prescribing during pregnancy was highest in the UK and Wales databases (9.4% (CI95 9.3% to 9.6%) and 9.4% (CI95 9.1% to 9.6%), respectively) and lowest in the Norwegian database (3.7% (CI95 3.7% to 3.8%)). In the year before pregnancy, the prevalence of asthma medication prescribing remained constant in all regions. Prescribing levels peaked during the second trimester of pregnancy and were at their lowest during the 3-month period following delivery. A decline was observed, in all regions except the UK, in the prescribing of long-acting β-2-agonists during pregnancy. During the 7-year study period, there were only small changes in prescribing patterns.Conclusions Differences were found in the prevalence of prescribing of asthma medications during and surrounding pregnancy in Europe. Inhaled β-2 agonists and inhaled corticosteroids were, however, the most popular therapeutic regimens in all databases.

    KW - EUROmediCAT

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    Charlton R, Pierini A, Klungsoyr K, Neville A, Jordan S, de Jong-van den Berg L et al. Asthma medication prescribing before, during and after pregnancy: a study in seven European regions. BMJ Open. 2016 Jan 1;6(1):0-0. https://doi.org/10.1136/bmjopen-2015-009237