Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study

JJ Strain, Philip W. Davidson, Maxine P. Bonham, Emeir M. Duffy, Abbie Stokes-Riner, Sally W. Thurston, Julie Wallace, Paula J. Robson, Conrad F. Shamlaye, Lesley A. Georger, Jean Sloane-Reeves, Elsa Cernichiari, Richard L. Canfield, Christopher Cox, Li Shan Huang, Joanne Janciuras, Gary J. Myers, Thomas W. Clarkson

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Abstract

Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development Nutrition Study (SCDNS). Specifically, we examined a priori models of Omega-3 and Omega-6 LCPUFA measures in maternal serum to test the hypothesis that these LCPUFA families before or after adjusting for prenatal MeHg exposure would reveal associations with child development assessed by the BSID-II at ages 9 and 30 months. There were 229 children with complete outcome and covariate data available for analysis. At 9 months, the PDI was positively associated with total Omega-3 LCPUFA and negatively associated with the ratio of Omega-6/Omega-3 LCPUFA. These associations were stronger in models adjusted for prenatal MeHg exposure. Secondary models suggested that the MeHg effect at 9 months varied by the ratio Omega-6/Omega-3 LCPUFA. There were no significant associations between LCPUFA measures and the PDI at 30 months. There were significant adverse associations, however, between prenatal MeHg and the 30-month PDI when the LCPUFA measures were included in the regression analysis. The BSID-II mental developmental index (MDI) was not associated with any exposure variable. These data support the potential importance to child development of prenatal availability of Omega-3 LCPUFA present in fish and of LCPUFA in the overall diet. Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies. (C) 2008 Elsevier Inc. All rights reserved.
LanguageEnglish
Pages776-782
JournalNeurotoxicology
Volume29
Issue number5, Sp.
DOIs
Publication statusPublished - Sep 2008

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Seychelles
Child Development
Mercury
Unsaturated Fatty Acids
Mothers
Fishes
Fetus
Growth and Development
Observational Studies
Longitudinal Studies

Cite this

Strain, JJ ; Davidson, Philip W. ; Bonham, Maxine P. ; Duffy, Emeir M. ; Stokes-Riner, Abbie ; Thurston, Sally W. ; Wallace, Julie ; Robson, Paula J. ; Shamlaye, Conrad F. ; Georger, Lesley A. ; Sloane-Reeves, Jean ; Cernichiari, Elsa ; Canfield, Richard L. ; Cox, Christopher ; Huang, Li Shan ; Janciuras, Joanne ; Myers, Gary J. ; Clarkson, Thomas W. / Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. 2008 ; Vol. 29, No. 5, Sp. pp. 776-782.
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abstract = "Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development Nutrition Study (SCDNS). Specifically, we examined a priori models of Omega-3 and Omega-6 LCPUFA measures in maternal serum to test the hypothesis that these LCPUFA families before or after adjusting for prenatal MeHg exposure would reveal associations with child development assessed by the BSID-II at ages 9 and 30 months. There were 229 children with complete outcome and covariate data available for analysis. At 9 months, the PDI was positively associated with total Omega-3 LCPUFA and negatively associated with the ratio of Omega-6/Omega-3 LCPUFA. These associations were stronger in models adjusted for prenatal MeHg exposure. Secondary models suggested that the MeHg effect at 9 months varied by the ratio Omega-6/Omega-3 LCPUFA. There were no significant associations between LCPUFA measures and the PDI at 30 months. There were significant adverse associations, however, between prenatal MeHg and the 30-month PDI when the LCPUFA measures were included in the regression analysis. The BSID-II mental developmental index (MDI) was not associated with any exposure variable. These data support the potential importance to child development of prenatal availability of Omega-3 LCPUFA present in fish and of LCPUFA in the overall diet. Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies. (C) 2008 Elsevier Inc. All rights reserved.",
author = "JJ Strain and Davidson, {Philip W.} and Bonham, {Maxine P.} and Duffy, {Emeir M.} and Abbie Stokes-Riner and Thurston, {Sally W.} and Julie Wallace and Robson, {Paula J.} and Shamlaye, {Conrad F.} and Georger, {Lesley A.} and Jean Sloane-Reeves and Elsa Cernichiari and Canfield, {Richard L.} and Christopher Cox and Huang, {Li Shan} and Joanne Janciuras and Myers, {Gary J.} and Clarkson, {Thomas W.}",
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Strain, JJ, Davidson, PW, Bonham, MP, Duffy, EM, Stokes-Riner, A, Thurston, SW, Wallace, J, Robson, PJ, Shamlaye, CF, Georger, LA, Sloane-Reeves, J, Cernichiari, E, Canfield, RL, Cox, C, Huang, LS, Janciuras, J, Myers, GJ & Clarkson, TW 2008, 'Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study', vol. 29, no. 5, Sp., pp. 776-782. https://doi.org/10.1016/j.neuro.2008.06.002

Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study. / Strain, JJ; Davidson, Philip W.; Bonham, Maxine P.; Duffy, Emeir M.; Stokes-Riner, Abbie; Thurston, Sally W.; Wallace, Julie; Robson, Paula J.; Shamlaye, Conrad F.; Georger, Lesley A.; Sloane-Reeves, Jean; Cernichiari, Elsa; Canfield, Richard L.; Cox, Christopher; Huang, Li Shan; Janciuras, Joanne; Myers, Gary J.; Clarkson, Thomas W.

Vol. 29, No. 5, Sp., 09.2008, p. 776-782.

Research output: Contribution to journalArticle

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T1 - Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study

AU - Strain, JJ

AU - Davidson, Philip W.

AU - Bonham, Maxine P.

AU - Duffy, Emeir M.

AU - Stokes-Riner, Abbie

AU - Thurston, Sally W.

AU - Wallace, Julie

AU - Robson, Paula J.

AU - Shamlaye, Conrad F.

AU - Georger, Lesley A.

AU - Sloane-Reeves, Jean

AU - Cernichiari, Elsa

AU - Canfield, Richard L.

AU - Cox, Christopher

AU - Huang, Li Shan

AU - Janciuras, Joanne

AU - Myers, Gary J.

AU - Clarkson, Thomas W.

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PY - 2008/9

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N2 - Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development Nutrition Study (SCDNS). Specifically, we examined a priori models of Omega-3 and Omega-6 LCPUFA measures in maternal serum to test the hypothesis that these LCPUFA families before or after adjusting for prenatal MeHg exposure would reveal associations with child development assessed by the BSID-II at ages 9 and 30 months. There were 229 children with complete outcome and covariate data available for analysis. At 9 months, the PDI was positively associated with total Omega-3 LCPUFA and negatively associated with the ratio of Omega-6/Omega-3 LCPUFA. These associations were stronger in models adjusted for prenatal MeHg exposure. Secondary models suggested that the MeHg effect at 9 months varied by the ratio Omega-6/Omega-3 LCPUFA. There were no significant associations between LCPUFA measures and the PDI at 30 months. There were significant adverse associations, however, between prenatal MeHg and the 30-month PDI when the LCPUFA measures were included in the regression analysis. The BSID-II mental developmental index (MDI) was not associated with any exposure variable. These data support the potential importance to child development of prenatal availability of Omega-3 LCPUFA present in fish and of LCPUFA in the overall diet. Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies. (C) 2008 Elsevier Inc. All rights reserved.

AB - Fish consumption during gestation can provide the fetus with long-chain polyunsaturated fatty acids (LCPUFA) and other nutrients essential for growth and development of the brain. However, fish consumption also exposes the fetus to the neurotoxicant, methyl mercury (MeHg). We studied the association between these fetal exposures and early child development in the Seychelles Child Development Nutrition Study (SCDNS). Specifically, we examined a priori models of Omega-3 and Omega-6 LCPUFA measures in maternal serum to test the hypothesis that these LCPUFA families before or after adjusting for prenatal MeHg exposure would reveal associations with child development assessed by the BSID-II at ages 9 and 30 months. There were 229 children with complete outcome and covariate data available for analysis. At 9 months, the PDI was positively associated with total Omega-3 LCPUFA and negatively associated with the ratio of Omega-6/Omega-3 LCPUFA. These associations were stronger in models adjusted for prenatal MeHg exposure. Secondary models suggested that the MeHg effect at 9 months varied by the ratio Omega-6/Omega-3 LCPUFA. There were no significant associations between LCPUFA measures and the PDI at 30 months. There were significant adverse associations, however, between prenatal MeHg and the 30-month PDI when the LCPUFA measures were included in the regression analysis. The BSID-II mental developmental index (MDI) was not associated with any exposure variable. These data support the potential importance to child development of prenatal availability of Omega-3 LCPUFA present in fish and of LCPUFA in the overall diet. Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies. (C) 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.neuro.2008.06.002

DO - 10.1016/j.neuro.2008.06.002

M3 - Article

VL - 29

SP - 776

EP - 782

IS - 5, Sp.

ER -