Associations of maternal immune response and MeHg exposure at 28 weeks gestation in the Seychelles Child Development Study: Methylmercury, PUFA and pregnancy immune function

Emeir M Mc Sorley, Alison J. Yeates, Maria S Mulhern, Edwin van Wijngaarden, Katherine Grzesik, Sally W. Thurston, Toni Spence, William Crowe, Philip W Davidson, Grazyna Zareba, Gary, J. Myers, Gene Watson, Conrad F. Shamlaye, J. J. Strain

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Problem: Maternal methylmercury (MeHg) exposure may be associated with immune response during pregnancy. Method of study: In the high fish‐eating Seychelles Child Development Study Nutrition Cohort 2, we examined the association between maternal MeHg, polyunsaturated fatty acids (PUFA), and immune markers (Th1:Th2; TNF‐α, IL‐1β, IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, MCP‐1, TARC, sFlt‐1, VEGF‐D, CRP and IL‐6) at 28 weeks’ gestation. Linear regression examined associations between MeHg exposure and immune markers with and without adjustment for PUFA. Results: In all models, as MeHg concentrations increased, the Th1:Th2 ratio, total Th1 and individual Th1 (IL‐1β, IL‐2, TNF‐α) concentrations decreased. MeHg was not associated with total Th2 cytokines but was associated with a decrease in IL‐4 and IL‐10. MeHg was positively associated with TARC and VEGF‐D and negatively associated with CRP. There was a significant interaction between MeHg and the n‐6:n‐3 ratio, with MeHg associated with a larger decrease in Th1:Th2 at higher n‐6:n‐3 PUFA ratios. The n‐3 PUFA were associated with lower CRP, IL‐4 and higher IFN‐γ. The n‐6 PUFA were associated with higher IL‐1β, IL‐2, TNF‐α, IL‐4, IL‐10, CRP and IL‐6. Conclusion:Maternal MeHg was associated with markers of immune function at 28 weeks’ gestation. A significant interaction between MeHg and the n‐6:n‐3 ratio on the Th1:Th2 ratio suggests that the n‐3 PUFA may mitigate any immunosuppressive associations of MeHg. The n‐3 and n‐6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance.
LanguageEnglish
Pages1-11
Number of pages11
JournalAmerican Journal of Reproductive Immunology
DOIs
Publication statusPublished - 17 Sep 2018

Fingerprint

Seychelles
Child Development
Unsaturated Fatty Acids
Interleukin-4
Omega-3 Fatty Acids
Vascular Endothelial Growth Factor D
Mothers
Interleukin-10
Interleukin-2
Pregnancy
Tumor Necrosis Factor-alpha
Biomarkers
Interleukin-6
Interleukin-5
Immunosuppressive Agents
Linear Models
Fishes
Cohort Studies
Eating
Cytokines

Keywords

  • Cytokines
  • immune function
  • Methylmercury
  • n-3 PUFA
  • pregnancy
  • Th1
  • Th2

Cite this

Mc Sorley, Emeir M ; Yeates, Alison J. ; Mulhern, Maria S ; van Wijngaarden, Edwin ; Grzesik, Katherine ; Thurston, Sally W. ; Spence, Toni ; Crowe, William ; Davidson, Philip W ; Zareba, Grazyna ; Myers, Gary, J. ; Watson, Gene ; Shamlaye, Conrad F. ; Strain, J. J. . / Associations of maternal immune response and MeHg exposure at 28 weeks gestation in the Seychelles Child Development Study : Methylmercury, PUFA and pregnancy immune function. In: American Journal of Reproductive Immunology. 2018 ; pp. 1-11.
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title = "Associations of maternal immune response and MeHg exposure at 28 weeks gestation in the Seychelles Child Development Study: Methylmercury, PUFA and pregnancy immune function",
abstract = "Problem: Maternal methylmercury (MeHg) exposure may be associated with immune response during pregnancy. Method of study: In the high fish‐eating Seychelles Child Development Study Nutrition Cohort 2, we examined the association between maternal MeHg, polyunsaturated fatty acids (PUFA), and immune markers (Th1:Th2; TNF‐α, IL‐1β, IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, MCP‐1, TARC, sFlt‐1, VEGF‐D, CRP and IL‐6) at 28 weeks’ gestation. Linear regression examined associations between MeHg exposure and immune markers with and without adjustment for PUFA. Results: In all models, as MeHg concentrations increased, the Th1:Th2 ratio, total Th1 and individual Th1 (IL‐1β, IL‐2, TNF‐α) concentrations decreased. MeHg was not associated with total Th2 cytokines but was associated with a decrease in IL‐4 and IL‐10. MeHg was positively associated with TARC and VEGF‐D and negatively associated with CRP. There was a significant interaction between MeHg and the n‐6:n‐3 ratio, with MeHg associated with a larger decrease in Th1:Th2 at higher n‐6:n‐3 PUFA ratios. The n‐3 PUFA were associated with lower CRP, IL‐4 and higher IFN‐γ. The n‐6 PUFA were associated with higher IL‐1β, IL‐2, TNF‐α, IL‐4, IL‐10, CRP and IL‐6. Conclusion:Maternal MeHg was associated with markers of immune function at 28 weeks’ gestation. A significant interaction between MeHg and the n‐6:n‐3 ratio on the Th1:Th2 ratio suggests that the n‐3 PUFA may mitigate any immunosuppressive associations of MeHg. The n‐3 and n‐6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance.",
keywords = "Cytokines, immune function, Methylmercury, n-3 PUFA, pregnancy, Th1, Th2",
author = "{Mc Sorley}, {Emeir M} and Yeates, {Alison J.} and Mulhern, {Maria S} and {van Wijngaarden}, Edwin and Katherine Grzesik and Thurston, {Sally W.} and Toni Spence and William Crowe and Davidson, {Philip W} and Grazyna Zareba and Myers, {Gary, J.} and Gene Watson and Shamlaye, {Conrad F.} and Strain, {J. J.}",
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Associations of maternal immune response and MeHg exposure at 28 weeks gestation in the Seychelles Child Development Study : Methylmercury, PUFA and pregnancy immune function. / Mc Sorley, Emeir M; Yeates, Alison J.; Mulhern, Maria S; van Wijngaarden, Edwin; Grzesik, Katherine; Thurston, Sally W.; Spence, Toni; Crowe, William; Davidson, Philip W; Zareba, Grazyna; Myers, Gary, J.; Watson, Gene; Shamlaye, Conrad F.; Strain, J. J. .

In: American Journal of Reproductive Immunology, 17.09.2018, p. 1-11.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of maternal immune response and MeHg exposure at 28 weeks gestation in the Seychelles Child Development Study

T2 - American Journal of Reproductive Immunology

AU - Mc Sorley, Emeir M

AU - Yeates, Alison J.

AU - Mulhern, Maria S

AU - van Wijngaarden, Edwin

AU - Grzesik, Katherine

AU - Thurston, Sally W.

AU - Spence, Toni

AU - Crowe, William

AU - Davidson, Philip W

AU - Zareba, Grazyna

AU - Myers, Gary, J.

AU - Watson, Gene

AU - Shamlaye, Conrad F.

AU - Strain, J. J.

PY - 2018/9/17

Y1 - 2018/9/17

N2 - Problem: Maternal methylmercury (MeHg) exposure may be associated with immune response during pregnancy. Method of study: In the high fish‐eating Seychelles Child Development Study Nutrition Cohort 2, we examined the association between maternal MeHg, polyunsaturated fatty acids (PUFA), and immune markers (Th1:Th2; TNF‐α, IL‐1β, IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, MCP‐1, TARC, sFlt‐1, VEGF‐D, CRP and IL‐6) at 28 weeks’ gestation. Linear regression examined associations between MeHg exposure and immune markers with and without adjustment for PUFA. Results: In all models, as MeHg concentrations increased, the Th1:Th2 ratio, total Th1 and individual Th1 (IL‐1β, IL‐2, TNF‐α) concentrations decreased. MeHg was not associated with total Th2 cytokines but was associated with a decrease in IL‐4 and IL‐10. MeHg was positively associated with TARC and VEGF‐D and negatively associated with CRP. There was a significant interaction between MeHg and the n‐6:n‐3 ratio, with MeHg associated with a larger decrease in Th1:Th2 at higher n‐6:n‐3 PUFA ratios. The n‐3 PUFA were associated with lower CRP, IL‐4 and higher IFN‐γ. The n‐6 PUFA were associated with higher IL‐1β, IL‐2, TNF‐α, IL‐4, IL‐10, CRP and IL‐6. Conclusion:Maternal MeHg was associated with markers of immune function at 28 weeks’ gestation. A significant interaction between MeHg and the n‐6:n‐3 ratio on the Th1:Th2 ratio suggests that the n‐3 PUFA may mitigate any immunosuppressive associations of MeHg. The n‐3 and n‐6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance.

AB - Problem: Maternal methylmercury (MeHg) exposure may be associated with immune response during pregnancy. Method of study: In the high fish‐eating Seychelles Child Development Study Nutrition Cohort 2, we examined the association between maternal MeHg, polyunsaturated fatty acids (PUFA), and immune markers (Th1:Th2; TNF‐α, IL‐1β, IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, MCP‐1, TARC, sFlt‐1, VEGF‐D, CRP and IL‐6) at 28 weeks’ gestation. Linear regression examined associations between MeHg exposure and immune markers with and without adjustment for PUFA. Results: In all models, as MeHg concentrations increased, the Th1:Th2 ratio, total Th1 and individual Th1 (IL‐1β, IL‐2, TNF‐α) concentrations decreased. MeHg was not associated with total Th2 cytokines but was associated with a decrease in IL‐4 and IL‐10. MeHg was positively associated with TARC and VEGF‐D and negatively associated with CRP. There was a significant interaction between MeHg and the n‐6:n‐3 ratio, with MeHg associated with a larger decrease in Th1:Th2 at higher n‐6:n‐3 PUFA ratios. The n‐3 PUFA were associated with lower CRP, IL‐4 and higher IFN‐γ. The n‐6 PUFA were associated with higher IL‐1β, IL‐2, TNF‐α, IL‐4, IL‐10, CRP and IL‐6. Conclusion:Maternal MeHg was associated with markers of immune function at 28 weeks’ gestation. A significant interaction between MeHg and the n‐6:n‐3 ratio on the Th1:Th2 ratio suggests that the n‐3 PUFA may mitigate any immunosuppressive associations of MeHg. The n‐3 and n‐6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance.

KW - Cytokines

KW - immune function

KW - Methylmercury

KW - n-3 PUFA

KW - pregnancy

KW - Th1

KW - Th2

U2 - 10.1111/aji.13046

DO - 10.1111/aji.13046

M3 - Article

SP - 1

EP - 11

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 1046-7408

ER -