Associations between neurocardiovascular signal entropy and physical frailty

Silvin P. Knight, Louise Newman, John D. O’connor, James Davis, Rose Anne Kenny, Roman Romero-Ortuno

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


In this cross-sectional study, the relationship between noninvasively measured neurocar-diovascular signal entropy and physical frailty was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study on Ageing (TILDA). The hypothesis under inves-tigation was that dysfunction in the neurovascular and cardiovascular systems, as quantified by short-length signal complexity during a lying-to-stand test (active stand), could provide a marker for frailty. Frailty status (i.e., “non-frail”, “pre-frail”, and “frail”) was based on Fried’s criteria (i.e., exhaustion, unexplained weight loss, weakness, slowness, and low physical activity). Approximate entropy (ApEn) and sample entropy (SampEn) were calculated during resting (lying down), active standing, and recovery phases. There was continuously measured blood pressure/heart rate data from 2645 individuals (53.0% female) and frontal lobe tissue oxygenation data from 2225 participants (52.3% female); both samples had a mean (SD) age of 64.3 (7.7) years. Results revealed statistically significant associations between neurocardiovascular signal entropy and frailty status. Entropy differences between non-frail and pre-frail/frail were greater during resting state compared with standing and recovery phases. Compared with ApEn, SampEn seemed to have better discriminating power between non-frail and pre-frail/frail individuals. The quantification of entropy in short length neurocardiovascular signals could provide a clinically useful marker of the multiple physiological dysregulations that underlie physical frailty.

Original languageEnglish
Article number4
Pages (from-to)1-19
Number of pages19
Issue number1
Publication statusPublished (in print/issue) - 22 Dec 2020

Bibliographical note

Funding Information:
Funding: This research was funded by Science Foundation Ireland (SFI), grant number 18/FRL/6188. The Irish Longitudinal Study on Ageing (TILDA) is funded by Atlantic Philanthropies, the Irish Department of Health and Irish Life.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Approximate entropy
  • Blood pressure
  • Cardiovascular
  • Frontal lobe oxygenation
  • Heart rate
  • Near infrared spectroscopy
  • Neurovascular
  • NIRS
  • Physical frailty
  • Sample entropy


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