Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study: Maternal inflammation and birth outcomes

Alison J. Yeates, Emeir M. McSorley, Maria S Mulhern, Toni Spence, William Crowe, Katherine Grzesik, Sally Thurston, Gene Watson, Gary Myers, Philip Davidson, Conrad Shamlaye, van Wijngaarden Edwin, Sean Strain

Research output: Contribution to journalArticle

Abstract

Problem: Markers of maternal inflammation may determine infant birth outcomes. Method of study: Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status. Results: Neither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β = −0.058, P = 0.017) and birth length (β = −0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β = −0.057, P = 0.023) and IL-2 (β = 0.073, P = 0.009) and the chemokine MCP-1 (β = 0.067, P = 0.016) were predictive of a longer gestational age. Conclusions: In our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy. n = 233.

LanguageEnglish
Article number102623
Number of pages6
JournalJournal of Reproductive Immunology
Volume137
Early online date23 Oct 2019
DOIs
Publication statusE-pub ahead of print - 23 Oct 2019

Fingerprint

Seychelles
Vascular Endothelial Growth Factor D
Child Development
Mothers
Parturition
Gestational Age
Inflammation
Interleukin-2
Pregnancy
Biomarkers
Linear Models
Interleukin-5
Maternal Age
Parity
Chemokines
Social Class
Interleukin-4
Interleukin-10
Pregnant Women
Interleukin-6

Keywords

  • Inflammation
  • Pregnancy
  • Immunology
  • Seychelles Child Development Study
  • Birth outcomes
  • Cytokines

Cite this

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title = "Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study: Maternal inflammation and birth outcomes",
abstract = "Problem: Markers of maternal inflammation may determine infant birth outcomes. Method of study: Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status. Results: Neither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β = −0.058, P = 0.017) and birth length (β = −0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β = −0.057, P = 0.023) and IL-2 (β = 0.073, P = 0.009) and the chemokine MCP-1 (β = 0.067, P = 0.016) were predictive of a longer gestational age. Conclusions: In our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy. n = 233.",
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author = "Yeates, {Alison J.} and McSorley, {Emeir M.} and Mulhern, {Maria S} and Toni Spence and William Crowe and Katherine Grzesik and Sally Thurston and Gene Watson and Gary Myers and Philip Davidson and Conrad Shamlaye and Edwin, {van Wijngaarden} and Sean Strain",
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Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study : Maternal inflammation and birth outcomes. / Yeates, Alison J.; McSorley, Emeir M.; Mulhern, Maria S; Spence, Toni; Crowe, William; Grzesik, Katherine ; Thurston, Sally; Watson, Gene; Myers, Gary; Davidson, Philip; Shamlaye, Conrad; Edwin, van Wijngaarden; Strain, Sean.

In: Journal of Reproductive Immunology, Vol. 137, 102623, 01.02.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between maternal inflammation during pregnancy and infant birth outcomes in the Seychelles Child Development Study

T2 - Journal of Reproductive Immunology

AU - Yeates, Alison J.

AU - McSorley, Emeir M.

AU - Mulhern, Maria S

AU - Spence, Toni

AU - Crowe, William

AU - Grzesik, Katherine

AU - Thurston, Sally

AU - Watson, Gene

AU - Myers, Gary

AU - Davidson, Philip

AU - Shamlaye, Conrad

AU - Edwin, van Wijngaarden

AU - Strain, Sean

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AB - Problem: Markers of maternal inflammation may determine infant birth outcomes. Method of study: Maternal serum samples were collected at 28 weeks gestation (n = 1418) in the Seychelles Child Development Study Nutrition Cohort 2 and analyzed for immune markers by MSD multiplex assay, including cytokines from the Th1 (IFN-γ, IL-1β, IL-2 and TNF-α) and Th2 (IL-4, IL-5, IL-10) subsets, with IL-6, MCP-1, TARC, sFlt-1 and VEGF-D. Associations of log-transformed immune markers with birthweight, length, head circumference and gestational age were assessed by multiple linear regression models, which were adjusted for maternal age, BMI, parity, child sex, gestational age and socioeconomic status. Results: Neither total Th1, Th2 nor Th1:Th2 were significantly associated with any birth outcome. However, the angiogenesis marker VEGF-D was predictive of a lower birthweight, (β = −0.058, P = 0.017) and birth length (β = −0.088, P = 0.001) after adjusting for covariates. Higher concentrations of CRP were predictive of a lower birthweight (β = −0.057, P = 0.023) and IL-2 (β = 0.073, P = 0.009) and the chemokine MCP-1 (β = 0.067, P = 0.016) were predictive of a longer gestational age. Conclusions: In our cohort of healthy pregnant women, we found no evidence for associations between the Th1 or Th2 inflammatory markers with birth outcomes. However, VEGF-D and CRP appear to predict lower birthweight and IL-2 and MCP-1 a longer gestation. Greater understanding is required of the variation in these immune markers at different gestational stages, as well as the factors which may regulate their balance in healthy pregnancy. n = 233.

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KW - Pregnancy

KW - Immunology

KW - Seychelles Child Development Study

KW - Birth outcomes

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