Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression

Peter de Jonge, Jordi Alonso, Dan J. Stein, Andrzej Kiejna, Sergio Aguilar-Gaxiola, Maria Carmen Viana, Zhaorui Liu, Siobhan O'Neill, Ronny Bruffaerts, Jose Miguel Caldas-de-Almeida, Jean Pierre Lépine, Herbert Matschinger, Daphna Levinson, Giovanni de Girolamo, Akira Fukao, B Bunting, Josep Maria Haro, Jose A. Posada-Villa, Ali Obaid Al-Hamzawi, Maria Elena Medina-Mora & 6 others Marina Piazza, Chiyi Hu, Carmen Sasu, Carmen C.W. Lim, Ronald C Kessler, Kate M Scott

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Aims/hypothesis
No studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.

Methods
We performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician’s diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.

Results
We identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.

Conclusions/interpretation
Depression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.
LanguageEnglish
Pages699-709
JournalDiabetologia
Volume57
Issue number4
Early online date2 Feb 2014
DOIs
Publication statusPublished - Apr 2014

Fingerprint

Disruptive, Impulse Control, and Conduct Disorders
Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders
Diabetes Mellitus
Social Adjustment
Depression
Comorbidity
Binge-Eating Disorder
Independent Living
Bulimia Nervosa
Age of Onset
Self Report
Type 2 Diabetes Mellitus
Psychiatry
Interviews
Physicians

Keywords

  • Comorbidity
  • Depression
  • Epidemiology
  • Impulse control disorders
  • Mental disorders

Cite this

de Jonge, P., Alonso, J., Stein, D. J., Kiejna, A., Aguilar-Gaxiola, S., Viana, M. C., ... Scott, K. M. (2014). Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression. Diabetologia, 57(4), 699-709. https://doi.org/10.1007/s00125-013-3157-9
de Jonge, Peter ; Alonso, Jordi ; Stein, Dan J. ; Kiejna, Andrzej ; Aguilar-Gaxiola, Sergio ; Viana, Maria Carmen ; Liu, Zhaorui ; O'Neill, Siobhan ; Bruffaerts, Ronny ; Caldas-de-Almeida, Jose Miguel ; Lépine, Jean Pierre ; Matschinger, Herbert ; Levinson, Daphna ; de Girolamo, Giovanni ; Fukao, Akira ; Bunting, B ; Haro, Josep Maria ; Posada-Villa, Jose A. ; Al-Hamzawi, Ali Obaid ; Medina-Mora, Maria Elena ; Piazza, Marina ; Hu, Chiyi ; Sasu, Carmen ; Lim, Carmen C.W. ; Kessler, Ronald C ; Scott, Kate M. / Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression. In: Diabetologia. 2014 ; Vol. 57, No. 4. pp. 699-709.
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abstract = "Aims/hypothesisNo studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.MethodsWe performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician’s diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.ResultsWe identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95{\%} CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95{\%} CI 1.1, 2.1), binge eating disorder (OR 2.6; 95{\%} CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95{\%} CI 1.3, 3.4) remained after comorbidity adjustment.Conclusions/interpretationDepression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.",
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author = "{de Jonge}, Peter and Jordi Alonso and Stein, {Dan J.} and Andrzej Kiejna and Sergio Aguilar-Gaxiola and Viana, {Maria Carmen} and Zhaorui Liu and Siobhan O'Neill and Ronny Bruffaerts and Caldas-de-Almeida, {Jose Miguel} and L{\'e}pine, {Jean Pierre} and Herbert Matschinger and Daphna Levinson and {de Girolamo}, Giovanni and Akira Fukao and B Bunting and Haro, {Josep Maria} and Posada-Villa, {Jose A.} and Al-Hamzawi, {Ali Obaid} and Medina-Mora, {Maria Elena} and Marina Piazza and Chiyi Hu and Carmen Sasu and Lim, {Carmen C.W.} and Kessler, {Ronald C} and Scott, {Kate M}",
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de Jonge, P, Alonso, J, Stein, DJ, Kiejna, A, Aguilar-Gaxiola, S, Viana, MC, Liu, Z, O'Neill, S, Bruffaerts, R, Caldas-de-Almeida, JM, Lépine, JP, Matschinger, H, Levinson, D, de Girolamo, G, Fukao, A, Bunting, B, Haro, JM, Posada-Villa, JA, Al-Hamzawi, AO, Medina-Mora, ME, Piazza, M, Hu, C, Sasu, C, Lim, CCW, Kessler, RC & Scott, KM 2014, 'Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression', Diabetologia, vol. 57, no. 4, pp. 699-709. https://doi.org/10.1007/s00125-013-3157-9

Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression. / de Jonge, Peter; Alonso, Jordi; Stein, Dan J.; Kiejna, Andrzej; Aguilar-Gaxiola, Sergio; Viana, Maria Carmen; Liu, Zhaorui; O'Neill, Siobhan; Bruffaerts, Ronny; Caldas-de-Almeida, Jose Miguel; Lépine, Jean Pierre; Matschinger, Herbert; Levinson, Daphna; de Girolamo, Giovanni; Fukao, Akira; Bunting, B; Haro, Josep Maria; Posada-Villa, Jose A.; Al-Hamzawi, Ali Obaid; Medina-Mora, Maria Elena; Piazza, Marina; Hu, Chiyi; Sasu, Carmen; Lim, Carmen C.W.; Kessler, Ronald C; Scott, Kate M.

In: Diabetologia, Vol. 57, No. 4, 04.2014, p. 699-709.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression

AU - de Jonge, Peter

AU - Alonso, Jordi

AU - Stein, Dan J.

AU - Kiejna, Andrzej

AU - Aguilar-Gaxiola, Sergio

AU - Viana, Maria Carmen

AU - Liu, Zhaorui

AU - O'Neill, Siobhan

AU - Bruffaerts, Ronny

AU - Caldas-de-Almeida, Jose Miguel

AU - Lépine, Jean Pierre

AU - Matschinger, Herbert

AU - Levinson, Daphna

AU - de Girolamo, Giovanni

AU - Fukao, Akira

AU - Bunting, B

AU - Haro, Josep Maria

AU - Posada-Villa, Jose A.

AU - Al-Hamzawi, Ali Obaid

AU - Medina-Mora, Maria Elena

AU - Piazza, Marina

AU - Hu, Chiyi

AU - Sasu, Carmen

AU - Lim, Carmen C.W.

AU - Kessler, Ronald C

AU - Scott, Kate M

PY - 2014/4

Y1 - 2014/4

N2 - Aims/hypothesisNo studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.MethodsWe performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician’s diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.ResultsWe identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.Conclusions/interpretationDepression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.

AB - Aims/hypothesisNo studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.MethodsWe performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician’s diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.ResultsWe identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.Conclusions/interpretationDepression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.

KW - Comorbidity

KW - Depression

KW - Epidemiology

KW - Impulse control disorders

KW - Mental disorders

UR - https://pure.ulster.ac.uk/en/publications/associations-between-dsm-iv-mental-disorders-and-diabetes-mellitu

U2 - 10.1007/s00125-013-3157-9

DO - 10.1007/s00125-013-3157-9

M3 - Article

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JO - Diabetologia

T2 - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -