Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review

Altijana Hromić-Jahjefendić, Debmalya Barh, Cecília Horta Ramalho Pinto, Lucas Gabriel Rodrigues Gomes, Jéssica Lígia Picanço Machado, Oladapo Olawale Afolabi, Sandeep Tiwari, Alaa A A Aljabali, Murtaza M Tambuwala, Ángel Serrano-Aroca, Elrashdy M Redwan, Vladimir N Uversky, Kenneth Lundstrom

Research output: Contribution to journalArticlepeer-review


Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.
Original languageEnglish
Pages (from-to)1-34
Number of pages34
Issue number5
Early online date27 Apr 2022
Publication statusE-pub ahead of print - 27 Apr 2022


  • Humans
  • SARS-CoV-2 - genetics
  • genetic susceptibility
  • Comorbidity
  • China
  • genetic diseases
  • congenital anomalies
  • COVID-19
  • disease incidence and association
  • Pandemics


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