Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review

Altijana Hromić-Jahjefendić; Debmalya Barh; Cecília Horta Ramalho Pinto; Lucas Gabriel Rodrigues Gomes; Jéssica Lígia Picanço Machado; Oladapo Olawale Afolabi; Sandeep Tiwari; Alaa A A Aljabali; Murtaza M Tambuwala; Ángel Serrano-Aroca; Elrashdy M Redwan; Vladimir N Uversky; Kenneth Lundstrom

doi:10.3390/v14050910

Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review

Altijana Hromić-Jahjefendić, Debmalya Barh, Cecília Horta Ramalho Pinto, Lucas Gabriel Rodrigues Gomes, Jéssica Lígia Picanço Machado, Oladapo Olawale Afolabi, Sandeep Tiwari, Alaa A A Aljabali, Murtaza M Tambuwala, Ángel Serrano-Aroca, Elrashdy M Redwan, Vladimir N Uversky, Kenneth Lundstrom

Research output: Contribution to journal › Review article › peer-review

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Abstract

Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.

Original language	English
Article number	910
Pages (from-to)	1-34
Number of pages	34
Journal	Viruses
Volume	14
Issue number	5
Early online date	27 Apr 2022
DOIs	https://doi.org/10.3390/v14050910
Publication status	Published online - 27 Apr 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Humans
SARS-CoV-2 - genetics
genetic susceptibility
Comorbidity
China
genetic diseases
congenital anomalies
COVID-19
disease incidence and association
Pandemics
Genetic susceptibility
Disease incidence and association
Congenital anomalies
Genetic diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/v14050910

viruses-14-00910Final published version, 3.3 MBLicence: CC BY

Cite this

Hromić-Jahjefendić, A., Barh, D., Ramalho Pinto, C. H., Gabriel Rodrigues Gomes, L., Picanço Machado, J. L., Afolabi, O. O., Tiwari, S., Aljabali, A. A. A., Tambuwala, M. M., Serrano-Aroca, Á., Redwan, E. M., Uversky, V. N., & Lundstrom, K. (2022). Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review. Viruses, 14(5), 1-34. [910]. https://doi.org/10.3390/v14050910

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title = "Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review",

abstract = "Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.",

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note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = apr,

day = "27",

doi = "10.3390/v14050910",

language = "English",

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Hromić-Jahjefendić, A, Barh, D, Ramalho Pinto, CH, Gabriel Rodrigues Gomes, L, Picanço Machado, JL, Afolabi, OO, Tiwari, S, Aljabali, AAA, Tambuwala, MM, Serrano-Aroca, Á, Redwan, EM, Uversky, VN & Lundstrom, K 2022, 'Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review', Viruses, vol. 14, no. 5, 910, pp. 1-34. https://doi.org/10.3390/v14050910

TY - JOUR

T1 - Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review

AU - Hromić-Jahjefendić, Altijana

AU - Barh, Debmalya

AU - Ramalho Pinto, Cecília Horta

AU - Gabriel Rodrigues Gomes, Lucas

AU - Picanço Machado, Jéssica Lígia

AU - Afolabi, Oladapo Olawale

AU - Tiwari, Sandeep

AU - Aljabali, Alaa A A

AU - Tambuwala, Murtaza M

AU - Serrano-Aroca, Ángel

AU - Redwan, Elrashdy M

AU - Uversky, Vladimir N

AU - Lundstrom, Kenneth

PY - 2022/4/27

Y1 - 2022/4/27

N2 - Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.

AB - Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.

KW - Humans

KW - SARS-CoV-2 - genetics

KW - genetic susceptibility

KW - Comorbidity

KW - China

KW - genetic diseases

KW - congenital anomalies

KW - COVID-19

KW - disease incidence and association

KW - Pandemics

KW - Genetic susceptibility

KW - Disease incidence and association

KW - Congenital anomalies

KW - Genetic diseases

UR - http://www.scopus.com/inward/record.url?scp=85131108758&partnerID=8YFLogxK

U2 - 10.3390/v14050910

DO - 10.3390/v14050910

M3 - Review article

C2 - 35632654

VL - 14

SP - 1

EP - 34

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 5

M1 - 910

ER -

Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review

Abstract

Bibliographical note

Keywords

UN SDGs

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