TY - JOUR
T1 - Associations and Disease-Disease Interactions of COVID-19 with Congenital and Genetic Disorders: A Comprehensive Review
AU - Hromić-Jahjefendić, Altijana
AU - Barh, Debmalya
AU - Ramalho Pinto, Cecília Horta
AU - Gabriel Rodrigues Gomes, Lucas
AU - Picanço Machado, Jéssica Lígia
AU - Afolabi, Oladapo Olawale
AU - Tiwari, Sandeep
AU - Aljabali, Alaa A A
AU - Tambuwala, Murtaza M
AU - Serrano-Aroca, Ángel
AU - Redwan, Elrashdy M
AU - Uversky, Vladimir N
AU - Lundstrom, Kenneth
PY - 2022/4/27
Y1 - 2022/4/27
N2 - Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.
AB - Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.
KW - Humans
KW - SARS-CoV-2 - genetics
KW - genetic susceptibility
KW - Comorbidity
KW - China
KW - genetic diseases
KW - congenital anomalies
KW - COVID-19
KW - disease incidence and association
KW - Pandemics
U2 - 10.3390/v14050910
DO - 10.3390/v14050910
M3 - Article
C2 - 35632654
VL - 14
SP - 1
EP - 34
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 5
ER -