Association of DNA Quadruplexes through G:C:G:C Tetrads. Solution Structure ofd(GCGGTGGAT)

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na+ solution hasbeen determined using molecular dynamics calculations constrained by distance and dihedral restraintsderived from NMR experiments performed at isotopic natural abundance. The sequence folds into a dimerof dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:Amismatch and by four-stranded G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composedof alternating antiparallel strands from the two halves of the dimer. For each single strand, a thymineintersperses a double chain reversal connecting the juxtaposed G:G:G:G tetrads. This architecture haspotential implications in genetic recombination. It suggests a pathway for oligomerization involvingassociation of quadruplex entities through GpC steps.
Original languageEnglish
Publication statusPublished (in print/issue) - 19 Nov 2003


Dive into the research topics of 'Association of DNA Quadruplexes through G:C:G:C Tetrads. Solution Structure ofd(GCGGTGGAT)'. Together they form a unique fingerprint.

Cite this