Association between mental disorders and subsequent adult onset asthma

Jordi Alonso, Peter de Jonge, Carmen C.W. Lim, Sergio Aguilar-Gaxiola, Ronny Bruffaerts, Jose Miguel Caldas-de-Almeida, Zhaorui Liu, Siobhan O'Neill, Dan J. Stein, Maria Carmen Viana, Ali Obaid Al-Hamzawi, Matthias C. Angermeyer, Guilherme Borges, Marius Ciutan, Giovanni de Girolamo, Fabian Fiestas, Josep Maria Haro, Chiyi Hu, Ronald C Kessler, Jean-Pierre Lepine & 5 others Daphna Levinson, Yosikazu Nakamura, Jose Posada-Villa, Bogdan J. Wojtyniak, Kate M Scott

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background and objectives: Associations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental disorders with adult onset of asthma and whether observed associations remain after mental comorbidity adjustments. Methods: During face-to-face household surveys in community-dwelling adults (n = 52,095) of 19 countries, the WHO Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Asthma was assessed by self-report of physician’s diagnosis together with age of onset. Survival analyses estimated associations between first onset of mental disorders and subsequent adult onset asthma, without and with comorbidity adjustment. Results: 1,860 adult onset (21 years+) asthma cases were identified, representing a total of 2,096,486 person-years of follow up. After adjustment for comorbid mental disorders several mental disorders were associated with subsequent adult asthma onset: bipolar (OR=1.8; 95%CI 1.3–2.4), panic (OR=1.4; 95%CI 1.0-2.0), generalized anxiety (OR=1.3; 95%CI 1.1–1.7), specific phobia (OR=1.4; 95%CI 1.2–1.6); post-traumatic stress (OR=1.5; 95%CI 1.1–2.0); binge eating (OR=1.9; 95%CI 1.2-2.9) and alcohol abuse (OR=1.5; 95%CI 1.2-2.0). Mental comorbidity linearly increased the association with adult asthma. The association with subsequent asthma was stronger for mental disorders with an early onset (before age 21). Conclusions: A wide range of temporally prior mental disorders are significantly associated with subsequent onset of asthma in adulthood. The extent to which asthma can be avoided or improved among those with early mental disorders deserves study.
LanguageEnglish
Pages179-188
Number of pages10
JournalJournal of Psychiatric Research
Volume59
Early online date16 Sep 2014
DOIs
Publication statusPublished - Dec 2014

Fingerprint

Mental Disorders
Asthma
Age of Onset
Social Adjustment
Comorbidity
Diagnostic and Statistical Manual of Mental Disorders
Independent Living
Bulimia
Panic
Survival Analysis
Anxiety Disorders
Mood Disorders
Self Report
Alcoholism
Anxiety
Interviews
Physicians

Keywords

  • Asthma
  • Mental disorders
  • Population
  • Epidemiology
  • Chronic Disease
  • Comorbidity

Cite this

Alonso, J., de Jonge, P., Lim, C. C. W., Aguilar-Gaxiola, S., Bruffaerts, R., Caldas-de-Almeida, J. M., ... Scott, K. M. (2014). Association between mental disorders and subsequent adult onset asthma. Journal of Psychiatric Research, 59, 179-188. https://doi.org/10.1016/j.jpsychires.2014.09.007
Alonso, Jordi ; de Jonge, Peter ; Lim, Carmen C.W. ; Aguilar-Gaxiola, Sergio ; Bruffaerts, Ronny ; Caldas-de-Almeida, Jose Miguel ; Liu, Zhaorui ; O'Neill, Siobhan ; Stein, Dan J. ; Viana, Maria Carmen ; Al-Hamzawi, Ali Obaid ; Angermeyer, Matthias C. ; Borges, Guilherme ; Ciutan, Marius ; de Girolamo, Giovanni ; Fiestas, Fabian ; Haro, Josep Maria ; Hu, Chiyi ; Kessler, Ronald C ; Lepine, Jean-Pierre ; Levinson, Daphna ; Nakamura, Yosikazu ; Posada-Villa, Jose ; Wojtyniak, Bogdan J. ; Scott, Kate M. / Association between mental disorders and subsequent adult onset asthma. In: Journal of Psychiatric Research. 2014 ; Vol. 59. pp. 179-188.
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abstract = "Background and objectives: Associations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental disorders with adult onset of asthma and whether observed associations remain after mental comorbidity adjustments. Methods: During face-to-face household surveys in community-dwelling adults (n = 52,095) of 19 countries, the WHO Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Asthma was assessed by self-report of physician’s diagnosis together with age of onset. Survival analyses estimated associations between first onset of mental disorders and subsequent adult onset asthma, without and with comorbidity adjustment. Results: 1,860 adult onset (21 years+) asthma cases were identified, representing a total of 2,096,486 person-years of follow up. After adjustment for comorbid mental disorders several mental disorders were associated with subsequent adult asthma onset: bipolar (OR=1.8; 95{\%}CI 1.3–2.4), panic (OR=1.4; 95{\%}CI 1.0-2.0), generalized anxiety (OR=1.3; 95{\%}CI 1.1–1.7), specific phobia (OR=1.4; 95{\%}CI 1.2–1.6); post-traumatic stress (OR=1.5; 95{\%}CI 1.1–2.0); binge eating (OR=1.9; 95{\%}CI 1.2-2.9) and alcohol abuse (OR=1.5; 95{\%}CI 1.2-2.0). Mental comorbidity linearly increased the association with adult asthma. The association with subsequent asthma was stronger for mental disorders with an early onset (before age 21). Conclusions: A wide range of temporally prior mental disorders are significantly associated with subsequent onset of asthma in adulthood. The extent to which asthma can be avoided or improved among those with early mental disorders deserves study.",
keywords = "Asthma, Mental disorders, Population, Epidemiology, Chronic Disease, Comorbidity",
author = "Jordi Alonso and {de Jonge}, Peter and Lim, {Carmen C.W.} and Sergio Aguilar-Gaxiola and Ronny Bruffaerts and Caldas-de-Almeida, {Jose Miguel} and Zhaorui Liu and Siobhan O'Neill and Stein, {Dan J.} and Viana, {Maria Carmen} and Al-Hamzawi, {Ali Obaid} and Angermeyer, {Matthias C.} and Guilherme Borges and Marius Ciutan and {de Girolamo}, Giovanni and Fabian Fiestas and Haro, {Josep Maria} and Chiyi Hu and Kessler, {Ronald C} and Jean-Pierre Lepine and Daphna Levinson and Yosikazu Nakamura and Jose Posada-Villa and Wojtyniak, {Bogdan J.} and Scott, {Kate M}",
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volume = "59",
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journal = "Journal of Psychiatric Research",
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Alonso, J, de Jonge, P, Lim, CCW, Aguilar-Gaxiola, S, Bruffaerts, R, Caldas-de-Almeida, JM, Liu, Z, O'Neill, S, Stein, DJ, Viana, MC, Al-Hamzawi, AO, Angermeyer, MC, Borges, G, Ciutan, M, de Girolamo, G, Fiestas, F, Haro, JM, Hu, C, Kessler, RC, Lepine, J-P, Levinson, D, Nakamura, Y, Posada-Villa, J, Wojtyniak, BJ & Scott, KM 2014, 'Association between mental disorders and subsequent adult onset asthma', Journal of Psychiatric Research, vol. 59, pp. 179-188. https://doi.org/10.1016/j.jpsychires.2014.09.007

Association between mental disorders and subsequent adult onset asthma. / Alonso, Jordi; de Jonge, Peter; Lim, Carmen C.W.; Aguilar-Gaxiola, Sergio; Bruffaerts, Ronny; Caldas-de-Almeida, Jose Miguel; Liu, Zhaorui; O'Neill, Siobhan; Stein, Dan J.; Viana, Maria Carmen; Al-Hamzawi, Ali Obaid; Angermeyer, Matthias C.; Borges, Guilherme; Ciutan, Marius; de Girolamo, Giovanni; Fiestas, Fabian; Haro, Josep Maria; Hu, Chiyi; Kessler, Ronald C; Lepine, Jean-Pierre; Levinson, Daphna; Nakamura, Yosikazu; Posada-Villa, Jose; Wojtyniak, Bogdan J.; Scott, Kate M.

In: Journal of Psychiatric Research, Vol. 59, 12.2014, p. 179-188.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between mental disorders and subsequent adult onset asthma

AU - Alonso, Jordi

AU - de Jonge, Peter

AU - Lim, Carmen C.W.

AU - Aguilar-Gaxiola, Sergio

AU - Bruffaerts, Ronny

AU - Caldas-de-Almeida, Jose Miguel

AU - Liu, Zhaorui

AU - O'Neill, Siobhan

AU - Stein, Dan J.

AU - Viana, Maria Carmen

AU - Al-Hamzawi, Ali Obaid

AU - Angermeyer, Matthias C.

AU - Borges, Guilherme

AU - Ciutan, Marius

AU - de Girolamo, Giovanni

AU - Fiestas, Fabian

AU - Haro, Josep Maria

AU - Hu, Chiyi

AU - Kessler, Ronald C

AU - Lepine, Jean-Pierre

AU - Levinson, Daphna

AU - Nakamura, Yosikazu

AU - Posada-Villa, Jose

AU - Wojtyniak, Bogdan J.

AU - Scott, Kate M

PY - 2014/12

Y1 - 2014/12

N2 - Background and objectives: Associations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental disorders with adult onset of asthma and whether observed associations remain after mental comorbidity adjustments. Methods: During face-to-face household surveys in community-dwelling adults (n = 52,095) of 19 countries, the WHO Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Asthma was assessed by self-report of physician’s diagnosis together with age of onset. Survival analyses estimated associations between first onset of mental disorders and subsequent adult onset asthma, without and with comorbidity adjustment. Results: 1,860 adult onset (21 years+) asthma cases were identified, representing a total of 2,096,486 person-years of follow up. After adjustment for comorbid mental disorders several mental disorders were associated with subsequent adult asthma onset: bipolar (OR=1.8; 95%CI 1.3–2.4), panic (OR=1.4; 95%CI 1.0-2.0), generalized anxiety (OR=1.3; 95%CI 1.1–1.7), specific phobia (OR=1.4; 95%CI 1.2–1.6); post-traumatic stress (OR=1.5; 95%CI 1.1–2.0); binge eating (OR=1.9; 95%CI 1.2-2.9) and alcohol abuse (OR=1.5; 95%CI 1.2-2.0). Mental comorbidity linearly increased the association with adult asthma. The association with subsequent asthma was stronger for mental disorders with an early onset (before age 21). Conclusions: A wide range of temporally prior mental disorders are significantly associated with subsequent onset of asthma in adulthood. The extent to which asthma can be avoided or improved among those with early mental disorders deserves study.

AB - Background and objectives: Associations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental disorders with adult onset of asthma and whether observed associations remain after mental comorbidity adjustments. Methods: During face-to-face household surveys in community-dwelling adults (n = 52,095) of 19 countries, the WHO Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Asthma was assessed by self-report of physician’s diagnosis together with age of onset. Survival analyses estimated associations between first onset of mental disorders and subsequent adult onset asthma, without and with comorbidity adjustment. Results: 1,860 adult onset (21 years+) asthma cases were identified, representing a total of 2,096,486 person-years of follow up. After adjustment for comorbid mental disorders several mental disorders were associated with subsequent adult asthma onset: bipolar (OR=1.8; 95%CI 1.3–2.4), panic (OR=1.4; 95%CI 1.0-2.0), generalized anxiety (OR=1.3; 95%CI 1.1–1.7), specific phobia (OR=1.4; 95%CI 1.2–1.6); post-traumatic stress (OR=1.5; 95%CI 1.1–2.0); binge eating (OR=1.9; 95%CI 1.2-2.9) and alcohol abuse (OR=1.5; 95%CI 1.2-2.0). Mental comorbidity linearly increased the association with adult asthma. The association with subsequent asthma was stronger for mental disorders with an early onset (before age 21). Conclusions: A wide range of temporally prior mental disorders are significantly associated with subsequent onset of asthma in adulthood. The extent to which asthma can be avoided or improved among those with early mental disorders deserves study.

KW - Asthma

KW - Mental disorders

KW - Population

KW - Epidemiology

KW - Chronic Disease

KW - Comorbidity

U2 - 10.1016/j.jpsychires.2014.09.007

DO - 10.1016/j.jpsychires.2014.09.007

M3 - Article

VL - 59

SP - 179

EP - 188

JO - Journal of Psychiatric Research

T2 - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

ER -

Alonso J, de Jonge P, Lim CCW, Aguilar-Gaxiola S, Bruffaerts R, Caldas-de-Almeida JM et al. Association between mental disorders and subsequent adult onset asthma. Journal of Psychiatric Research. 2014 Dec;59:179-188. https://doi.org/10.1016/j.jpsychires.2014.09.007