Assisted Standing for Duchenne Muscular Dystrophy

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
308 Downloads (Pure)


Background Duchenne muscular dystrophy (DMD) is the most common X-linked neuromuscular disorder. When boys with DMD reach the second decade of life, they lose their ability to walk and become wheelchair dependent. Standing devices and orthoses are considered to be an essential component in the therapy management of DMD. Clinical opinion and research from other neurological conditions highlight the proposed benefits of standing device use, however, its effect within this population is currently unknown. A review of the evidence for the use of standing devices and orthoses is necessary to inform all stakeholders, including people with DMD, clinicians, decision makers and funders, and to guide future research. Objectives To assess the effects of standing devices and orthoses on musculoskeletal impairments (such as pain, contracture, scoliosis development and bone density) in boys and men with DMD, and secondarily to determine their effect on quality of life, participation in activities, and patient experience (satisfaction). We also considered any adverse events associated with their use. Search methods We searched the Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, Embase, AMED, PsycINFO, CINAHL Plus, PEDro, and ProQuest Dissertations & Theses Global up to 5 September 2019. We checked references in identified trials, handsearched journal abstracts, and searched trials registries. Selection criteria We planned to include randomised controlled trials (RCTs) and quasi-RCTs of any model of standing device for use in DMD. The control interventions would have been any other comparison group, including no standing device, a different model of standing device, usual care, or an alternative form of assistive weight bearing. Data collection and analysis We used standard Cochrane methodological procedures. Main results Although we identified 13 potentially relevant studies, none met the inclusion criteria for this review. Authors' conclusions Since there were no RCTs or quasi-RCTs available to evaluate the effectiveness of standing devices in people with DMD, studies are needed to investigate the effectiveness of standing devices in this population.

Original languageEnglish
Article numberCD011550
JournalCochrane Database of Systematic Reviews
Issue number10
Publication statusPublished (in print/issue) - 13 Oct 2019

Bibliographical note

Funding Information:
The review authors would like to acknowledge the Research and Development Division of the Public Health Agency (Northern Ire-land) for their funding of the Cochrane Fellowship for Katy Pedlow. The Cochrane Neuromuscular Information Specialist, Angela Gunn, developed search strategies in collaboration with the review authors. This project was supported by the National Institute for Health Research via Cochrane Infrastructure funding to Cochrane Neuromuscular. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the Systematic Reviews Programme, NIHR, NHS or the Department of Health. Cochrane Neuromuscular is also supported by the MRCCentre for Neuromuscular Disease.

Publisher Copyright:
© 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Copyright 2019 Elsevier B.V., All rights reserved.


Dive into the research topics of 'Assisted Standing for Duchenne Muscular Dystrophy'. Together they form a unique fingerprint.

Cite this