Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status

M Edel, P Robbins, M D'Antuono, J Harvey, J Papadimitriou, Christopher Mitchell, H Dawkins

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Abstract

The correlation between angiogenesis as assessed by endothelial cell proliferation in blood/lymphatic vessels in primary breast carcinomas, and axillary lymph-node metastasis was studied using a case-control design. Primary breast carcinomas, < 2 cm in diameter, from 26 axillary node positive patients (case), were compared with neoplasms from 45 node-negative patients (control). Vascularity, as assessed by vessel density, and endothelial eel proliferation were measured in a single tissue section using a double immunohistochemical staining technique using MIBI (Ki-67) and FVIII antibodies. No association between vascularity and node status was found (P > 0.70). Node positive breast carcinomas had, on average, significantly smaller proliferating vessels (140+/-7 mu m in perimeter) in the primary lesion when compared with node negative tumours (164+/-7 mu m) in perimeter (P<0.02). In addition, the frequency of relatively small vessels (less than 180 mu m in perimeter) with proliferating endothelium was higher in node positive carcinomas than lymph-node negative neoplasms (P<0.03). This association between node status and the size and frequency of blood/lymphatic vessels with proliferating endothelium in primary carcinoma may have important implications in metastasis. (C) 2000 Harcourt Publishers Ltd.
LanguageEnglish
Pages28-34
JournalBreast
Volume9
Issue number1
Publication statusPublished - Feb 2000

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Lymphatic Vessels
Endothelial Cells
Lymph Nodes
Cell Proliferation
Breast Neoplasms
Endothelium
Blood Vessels
Neoplasm Metastasis
Carcinoma
Neoplasms

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Edel, M., Robbins, P., D'Antuono, M., Harvey, J., Papadimitriou, J., Mitchell, C., & Dawkins, H. (2000). Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status. Breast, 9(1), 28-34.
Edel, M ; Robbins, P ; D'Antuono, M ; Harvey, J ; Papadimitriou, J ; Mitchell, Christopher ; Dawkins, H. / Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status. In: Breast. 2000 ; Vol. 9, No. 1. pp. 28-34.
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abstract = "The correlation between angiogenesis as assessed by endothelial cell proliferation in blood/lymphatic vessels in primary breast carcinomas, and axillary lymph-node metastasis was studied using a case-control design. Primary breast carcinomas, < 2 cm in diameter, from 26 axillary node positive patients (case), were compared with neoplasms from 45 node-negative patients (control). Vascularity, as assessed by vessel density, and endothelial eel proliferation were measured in a single tissue section using a double immunohistochemical staining technique using MIBI (Ki-67) and FVIII antibodies. No association between vascularity and node status was found (P > 0.70). Node positive breast carcinomas had, on average, significantly smaller proliferating vessels (140+/-7 mu m in perimeter) in the primary lesion when compared with node negative tumours (164+/-7 mu m) in perimeter (P<0.02). In addition, the frequency of relatively small vessels (less than 180 mu m in perimeter) with proliferating endothelium was higher in node positive carcinomas than lymph-node negative neoplasms (P<0.03). This association between node status and the size and frequency of blood/lymphatic vessels with proliferating endothelium in primary carcinoma may have important implications in metastasis. (C) 2000 Harcourt Publishers Ltd.",
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Edel, M, Robbins, P, D'Antuono, M, Harvey, J, Papadimitriou, J, Mitchell, C & Dawkins, H 2000, 'Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status', Breast, vol. 9, no. 1, pp. 28-34.

Assessment of endothelial cell proliferation in primary breast carcinoma and its association with axillary lymph node status. / Edel, M; Robbins, P; D'Antuono, M; Harvey, J; Papadimitriou, J; Mitchell, Christopher; Dawkins, H.

In: Breast, Vol. 9, No. 1, 02.2000, p. 28-34.

Research output: Contribution to journalArticle

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AB - The correlation between angiogenesis as assessed by endothelial cell proliferation in blood/lymphatic vessels in primary breast carcinomas, and axillary lymph-node metastasis was studied using a case-control design. Primary breast carcinomas, < 2 cm in diameter, from 26 axillary node positive patients (case), were compared with neoplasms from 45 node-negative patients (control). Vascularity, as assessed by vessel density, and endothelial eel proliferation were measured in a single tissue section using a double immunohistochemical staining technique using MIBI (Ki-67) and FVIII antibodies. No association between vascularity and node status was found (P > 0.70). Node positive breast carcinomas had, on average, significantly smaller proliferating vessels (140+/-7 mu m in perimeter) in the primary lesion when compared with node negative tumours (164+/-7 mu m) in perimeter (P<0.02). In addition, the frequency of relatively small vessels (less than 180 mu m in perimeter) with proliferating endothelium was higher in node positive carcinomas than lymph-node negative neoplasms (P<0.03). This association between node status and the size and frequency of blood/lymphatic vessels with proliferating endothelium in primary carcinoma may have important implications in metastasis. (C) 2000 Harcourt Publishers Ltd.

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