Assessing the impact of antimicrobial stewardship implementation at a district hospital in Ghana using a health partnership model

Obed Kwabena Offe Amponsah, Aaron Courtenay, Nana Kwame Ayisi-Boateng, Ahmed Abuelhana, Douglas Aninng Opoku, Lawrence Kobina Blay, Nana Akua Abruquah, Annabella Bensusan Osafo, Charlotte Boachie Danquah, Phyllis Tawiah, Mercy Naa Aduele Opare-Addo, Alex Owusu-Ofori, Kwame Ohene Buabeng

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Background Antimicrobial stewardship (AMS) is imperative in addressing the menace of antimicrobial resistance (AMR) in health systems. Commonwealth Partnerships for Antimicrobial Stewardship uses a health partnership model to establish AMS in Commonwealth countries. The Hospital of Kwame Nkrumah University of Science and Technology in partnership with Ulster University, Northern Ireland, undertook an AMS project from November 2021 to May 2022. We report on implementation of the AMS, its impact on antibiotic use and infections management at the University Hospital; Kumasi, Ghana. Methods The Global-Point Prevalence Survey (PPS) protocol was used to assess antibiotics use at the hospital at baseline, midpoint and end of the project. Feedback on each PPS was given to the hospital to inform practice, behavioural change and improve antibiotic use. Results Antibiotic use reduced from 65% at baseline to 59.7% at the end of the project. The rate of healthcare-associated infections also reduced from 17.5% at baseline to 6.5%. Use of antibiotics from the WHO Access group was 40% at baseline but increased to 50% at the endpoint. Watch antibiotics reduced from 60% to 50% from baseline. Culture and susceptibility requests increased from baseline of 111 total requests to 330 requests in the intervention period to inform antimicrobial therapy Conclusion The model AMS instituted improved antibiotic use and quality of antimicrobial therapy within the study period. Continuous staff education and training in AMS, and use of standard tools for assessment and application of local data to inform infections management will ensure sustenance and improvement in the gains made.
Original languageEnglish
Article numberdlad084
Pages (from-to)1-7
Number of pages8
JournalJAC-Antimicrobial Resistance
Issue number4
Publication statusPublished (in print/issue) - 17 Jul 2023

Bibliographical note

Funding Information:
This study was supported by the Commonwealth Partnerships for Antimicrobial Stewardship (CwPAMS) (grant reference A11) programmes supported by Tropical Health and Education Trust (THET) and Commonwealth Pharmacists Association (CPA) using Official Development Assistance (ODA) funding, through the Department of Health and Social Care’s Fleming Fund. UK partners involved were volunteers supported by their host NHS organizations.

Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.


  • Microbiology (medical)
  • Infectious Diseases
  • Immunology and Allergy
  • Microbiology
  • Immunology


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