Aqueous Bark Extracts of Terminalia Arjuna Stimulates Insulin Release, Enhances Insulin Action and Inhibits Starch Digestion and Protein Glycation in Vitro

HAJ Thomson, Opeolu Ojo, Peter Flatt, YHA Abdel-Wahab

Research output: Contribution to journalArticle

Abstract

Scientific evidence for the effects of Terminalia arjuna on diabetes mellitus is lacking. This study investigated the anti-diabetic efficacy and mode of action of the bark extract of Terminalia arjuna. Insulin-release from BRIN-BD11 cells was assessed in the absence or presence of T. arjuna extracts and modulators of insulin-secretion. Insulin concentration and intracellular calcium ([Ca2+]i) were measured by radioimmunoassay and FLEXstationTM respectively. Adipocyte glucose-uptake with 3T3-L1 fibroblasts, starch digestion with α–amylase and protein glycation were assessed in vitro. Terminalia arjuna extract stimulated insulin-release alone (p
Original languageEnglish
Pages (from-to)1001
JournalAustin Journal of Endocrinology and Diabetes
Volume1
Issue number1
Publication statusPublished - 20 Jan 2014

Keywords

  • Terminalia arjuna
  • diabetes
  • insulin
  • glucose uptake

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