AQ4N: a new approach to hypoxia-activated cancer chemotherapy

LH Patterson, Stephanie McKeown

    Research output: Contribution to journalArticle

    118 Citations (Scopus)

    Abstract

    Preclinical studies demonstrate that in vivo AQ4N enhances the anti-tumour effects of radiation and chemotherapeutic agents with a dose-modifying factor of approximately 2.0. With careful scheduling no, or very little, additional normal tissue toxicity should be observed. AQ4N is a bioreductive prodrug of a potent, stable, reduction product which binds non-covalently to DNA, facilitating antitumour activity in both hypoxic and proximate oxic tumour cells. AQ4N is clearly different in both its mechanism of action and potential bystander effect compared to previously identified bioreductive drugs. In particular AQ4N is the only bioreductive prodrug topoisomerase II inhibitor to enter clinical trials. Targeting this enzyme, which is crucial to cell division, may help sensitize tumours to repeated (fractionated) courses of radiotherapy. This is because in principle, the bioreduction product of AQ4N can inhibit the topoisomerase activity of hypoxic cells as they attempt to re-enter the cell cycle. (C) 2000 Cancer Research Campaign.
    Original languageEnglish
    Pages (from-to)1589-1593
    JournalBRITISH JOURNAL OF CANCER
    Volume83
    Issue number12
    DOIs
    Publication statusPublished - Dec 2000

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