Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices

Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming Wei Chang, Raid G. Alany, Zeeshan Ahmad

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery. A summary table will provide quick reference to note the key findings in this area. In addition, the review also elucidates current theranostic and diagnostic approaches based on ocular lenses.

LanguageEnglish
Pages521-541
Number of pages21
JournalTherapeutic Delivery
Volume8
Issue number7
Early online date21 Jun 2017
DOIs
Publication statusPublished - 1 Jul 2017

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Contact Lenses
Equipment and Supplies
Pharmaceutical Preparations
Crystalline Lens
Nanotechnology
Lenses
Technology
Therapeutics

Keywords

  • contact lenses
  • drug loading
  • emulsions
  • hydrogel
  • matrix composition
  • nanotechnology
  • ocular drug delivery
  • theranostic

Cite this

Mehta, Prina ; Haj-Ahmad, Rita ; Al-Kinani, Ali ; Arshad, Muhammad Sohail ; Chang, Ming Wei ; Alany, Raid G. ; Ahmad, Zeeshan. / Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices. In: Therapeutic Delivery. 2017 ; Vol. 8, No. 7. pp. 521-541.
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abstract = "Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery. A summary table will provide quick reference to note the key findings in this area. In addition, the review also elucidates current theranostic and diagnostic approaches based on ocular lenses.",
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Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices. / Mehta, Prina; Haj-Ahmad, Rita; Al-Kinani, Ali; Arshad, Muhammad Sohail; Chang, Ming Wei; Alany, Raid G.; Ahmad, Zeeshan.

In: Therapeutic Delivery, Vol. 8, No. 7, 01.07.2017, p. 521-541.

Research output: Contribution to journalReview article

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AU - Chang, Ming Wei

AU - Alany, Raid G.

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