Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Yasmine Alyassin; Elshaimaa G. Sayed; Prina Mehta; Ketan Ruparelia; Muhammad S. Arshad; Manoochehr Rasekh; Jennifer Shepherd; Israfil Kucuk; Philippe B. Wilson; Neenu Singh; Ming-Wei Chang; Dimitrios G. Fatouros; Zeeshan Ahmad

doi:10.1016/j.drudis.2020.06.006

Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Yasmine Alyassin, Elshaimaa G. Sayed, Prina Mehta, Ketan Ruparelia, Muhammad S. Arshad, Manoochehr Rasekh, Jennifer Shepherd, Israfil Kucuk, Philippe B. Wilson, Neenu Singh, Ming-Wei Chang, Dimitrios G. Fatouros, Zeeshan Ahmad

Research output: Contribution to journal › Review article › peer-review

93 Citations (Scopus)

Abstract

Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.

Original language	English
Pages (from-to)	1513-1520
Journal	Drug Discovery Today
Volume	25
Issue number	8
Early online date	16 Jun 2020
DOIs	https://doi.org/10.1016/j.drudis.2020.06.006
Publication status	Published (in print/issue) - Aug 2020

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10.1016/j.drudis.2020.06.006

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title = "Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents",

abstract = "Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.",

author = "Yasmine Alyassin and Sayed, {Elshaimaa G.} and Prina Mehta and Ketan Ruparelia and Arshad, {Muhammad S.} and Manoochehr Rasekh and Jennifer Shepherd and Israfil Kucuk and Wilson, {Philippe B.} and Neenu Singh and Ming-Wei Chang and Fatouros, {Dimitrios G.} and Zeeshan Ahmad",

year = "2020",

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doi = "10.1016/j.drudis.2020.06.006",

language = "English",

volume = "25",

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journal = "Drug Discovery Today",

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T1 - Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

AU - Alyassin, Yasmine

AU - Sayed, Elshaimaa G.

AU - Mehta, Prina

AU - Ruparelia, Ketan

AU - Arshad, Muhammad S.

AU - Rasekh, Manoochehr

AU - Shepherd, Jennifer

AU - Kucuk, Israfil

AU - Wilson, Philippe B.

AU - Singh, Neenu

AU - Chang, Ming-Wei

AU - Fatouros, Dimitrios G.

AU - Ahmad, Zeeshan

PY - 2020/8

Y1 - 2020/8

N2 - Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.

AB - Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.

U2 - 10.1016/j.drudis.2020.06.006

DO - 10.1016/j.drudis.2020.06.006

M3 - Review article

C2 - 32561300

SN - 1359-6446

VL - 25

SP - 1513

EP - 1520

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Abstract

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