Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Yasmine Alyassin, Elshaimaa G. Sayed, Prina Mehta, Ketan Ruparelia, Muhammad S. Arshad, Manoochehr Rasekh, Jennifer Shepherd, Israfil Kucuk, Philippe B. Wilson, Neenu Singh, Ming-Wei Chang, Dimitrios G. Fatouros, Zeeshan Ahmad

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

Recently, remarkable efforts have focused on research towards enhancing and delivering efficacious and advanced therapeutic agents. Even though this involves significant challenges, innovative techniques and materials have been explored to overcome these. The advantageous properties of mesoporous silica nanoparticles (MSNs), such as unique morphologies and geometries, makes then favorable for use for various drug delivery targeting purposes, particularly in cancer therapy. As we discuss here, MSNs have been utilized over the past few decades to improve the efficiency of anticancer drugs by enhancing their solubility to render them suitable for application, reducing adverse effects, and improving their anticancer cytotoxic efficiency.
Original languageEnglish
Pages (from-to)1513-1520
JournalDrug Discovery Today
Volume25
Issue number8
Early online date16 Jun 2020
DOIs
Publication statusPublished - Aug 2020

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