Apoptosis time window induced by cold atmospheric plasma: comparison with ionizing radiation

Gordana Joksić, Ana Valenta Šobot, Jelena Filipović Tričković, Dejan Maletić, Nevena Puač, Gordana Malović, Zoran Petrovic, Saša Lazović

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this study we evaluate apoptosis time window of primary fibroblasts treated with cold atmospheric plasma (CAP), power range 0.4–1.4 W, for 30 sec, using γ-H2AX phosphorylation assay and flow cytometry. In contrast to irradiation where maximum of γ-H2AX foci appeared 30 min after irradiation and apoptosis 24 h later irrespective of radiation dose, treatment with CAP (power of 0.4 and 0.6) induces maximum of γ-H2AX foci 2 h after treatment. Apoptosis occurred in a power-dependent manner, with time shift of
2–3 h. Besides power-dependent time shift in apoptosis induction, apoptosis time window is the same and lasts for 2 h.
Original languageEnglish
Pages (from-to)1229-1233
Number of pages5
JournalCurrent Science
Volume116
Issue number7
DOIs
Publication statusPublished - 2019

Keywords

  • Apoptosis
  • repair kinetics
  • primary human fibroblasts
  • ionizing radiation
  • cold atmospheric plasma

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