Antihyperglycaemic effect of saccharin in diabetic ob/ob mice

CJ Bailey, C Day, JME Knapper, SL Turner, Peter Flatt

Research output: Contribution to journalArticle

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Abstract

1 The effect of chronic saccharin (benzosulphimide) consumption on glucose homeostasis was examined in normal lean +/+ mice and genetically obese hyperglycaemic insulin-resistant ob/ob mice. 2 Consumption of a 5% (w/v) sodium saccharin solution for 7 weeks prevented the development of hyperglycaemia, improved glucose tolerance (area under curve decreased by 51%), reduced the extent of hyperinsulinaemia (by 21%), and reduced excessive weight gain (by 18%) in ob/ob mice. 3 Consumption of 5% (w/v) sodium saccharin temporarily decreased hyperphagia at the beginning of treatment, decreased hepatic glycogen content (by 47%), increased abdominal muscle glycogen content (by 82%), but did not significantly alter the hypoglycaemic response to exogenous insulin in ob/ob mice. 4 Consumption of a 1% (w/v) sodium saccharin solution did not prevent the development of hyperglycaemia in ob/ob mice. 5 Normal lean +/+ mice consuming 5% (w/v) sodium saccharin solution showed a marginal decrease (by 8%) in glycaemia, and glucose tolerance was improved (area under curve decreased by 30%) without a significant change in the insulin response to glucose or the hypoglycaemic effect of exogenous insulin. 6 The results suggest that chronic consumption of saccharin can defer the development of hyperglycaemia and improve glucose homeostasis in insulin-resistant ob/ob mice through a mechanism that is independent of insulin.
LanguageEnglish
Pages74-78
JournalBritish Journal of Pharmacology
Volume120
Issue number1
Publication statusPublished - Jan 1997

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Saccharin
Hypoglycemic Agents
Insulin
Glucose
Hyperglycemia
Area Under Curve
Homeostasis
Abdominal Muscles
Obese Mice
Hyperphagia
Liver Glycogen
Hyperinsulinism
Glycogen
Weight Gain

Cite this

Bailey, CJ., Day, C., Knapper, JME., Turner, SL., & Flatt, P. (1997). Antihyperglycaemic effect of saccharin in diabetic ob/ob mice. British Journal of Pharmacology, 120(1), 74-78.
Bailey, CJ ; Day, C ; Knapper, JME ; Turner, SL ; Flatt, Peter. / Antihyperglycaemic effect of saccharin in diabetic ob/ob mice. In: British Journal of Pharmacology. 1997 ; Vol. 120, No. 1. pp. 74-78.
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Bailey, CJ, Day, C, Knapper, JME, Turner, SL & Flatt, P 1997, 'Antihyperglycaemic effect of saccharin in diabetic ob/ob mice', British Journal of Pharmacology, vol. 120, no. 1, pp. 74-78.

Antihyperglycaemic effect of saccharin in diabetic ob/ob mice. / Bailey, CJ; Day, C; Knapper, JME; Turner, SL; Flatt, Peter.

In: British Journal of Pharmacology, Vol. 120, No. 1, 01.1997, p. 74-78.

Research output: Contribution to journalArticle

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AB - 1 The effect of chronic saccharin (benzosulphimide) consumption on glucose homeostasis was examined in normal lean +/+ mice and genetically obese hyperglycaemic insulin-resistant ob/ob mice. 2 Consumption of a 5% (w/v) sodium saccharin solution for 7 weeks prevented the development of hyperglycaemia, improved glucose tolerance (area under curve decreased by 51%), reduced the extent of hyperinsulinaemia (by 21%), and reduced excessive weight gain (by 18%) in ob/ob mice. 3 Consumption of 5% (w/v) sodium saccharin temporarily decreased hyperphagia at the beginning of treatment, decreased hepatic glycogen content (by 47%), increased abdominal muscle glycogen content (by 82%), but did not significantly alter the hypoglycaemic response to exogenous insulin in ob/ob mice. 4 Consumption of a 1% (w/v) sodium saccharin solution did not prevent the development of hyperglycaemia in ob/ob mice. 5 Normal lean +/+ mice consuming 5% (w/v) sodium saccharin solution showed a marginal decrease (by 8%) in glycaemia, and glucose tolerance was improved (area under curve decreased by 30%) without a significant change in the insulin response to glucose or the hypoglycaemic effect of exogenous insulin. 6 The results suggest that chronic consumption of saccharin can defer the development of hyperglycaemia and improve glucose homeostasis in insulin-resistant ob/ob mice through a mechanism that is independent of insulin.

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Bailey CJ, Day C, Knapper JME, Turner SL, Flatt P. Antihyperglycaemic effect of saccharin in diabetic ob/ob mice. British Journal of Pharmacology. 1997 Jan;120(1):74-78.