Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice

Nigel Irwin; Kerry Hunter; Norma Frizzell; Peter Flatt

doi:10.1016/j.regpep.2008.11.007

Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice

Nigel Irwin
, Kerry Hunter
, Norma Frizzell
, Peter Flatt

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

GLP-1 and GIP are the two key incretin hormones that regulate post-prandial glucose homeostasis. Furthermore, potent enzyme-resistant GIP and GLP-1 receptor agonists such as N-AcGIP and exendin-4 have now been developed. In the present study the effects of stable incretins, exendin-4 and N-AcGIP alone and in combination were examined in mice with high fat feeding induced glucose intolerance. Daily s.c. injections of exendin-4 (50 nmol/kg bw) for 12 days restored glycaemic control and significantly (P

Original language	English
Pages (from-to)	70-76
Journal	Regulatory Peptides
Volume	153
Issue number	1-3
DOIs	https://doi.org/10.1016/j.regpep.2008.11.007
Publication status	Published (in print/issue) - Feb 2009

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10.1016/j.regpep.2008.11.007

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AU - Hunter, Kerry

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AU - Flatt, Peter

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AB - GLP-1 and GIP are the two key incretin hormones that regulate post-prandial glucose homeostasis. Furthermore, potent enzyme-resistant GIP and GLP-1 receptor agonists such as N-AcGIP and exendin-4 have now been developed. In the present study the effects of stable incretins, exendin-4 and N-AcGIP alone and in combination were examined in mice with high fat feeding induced glucose intolerance. Daily s.c. injections of exendin-4 (50 nmol/kg bw) for 12 days restored glycaemic control and significantly (P

U2 - 10.1016/j.regpep.2008.11.007

DO - 10.1016/j.regpep.2008.11.007

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ER -

Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice

Abstract

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