Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice

Nigel Irwin, Kerry Hunter, Norma Frizzell, Peter Flatt

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

GLP-1 and GIP are the two key incretin hormones that regulate post-prandial glucose homeostasis. Furthermore, potent enzyme-resistant GIP and GLP-1 receptor agonists such as N-AcGIP and exendin-4 have now been developed. In the present study the effects of stable incretins, exendin-4 and N-AcGIP alone and in combination were examined in mice with high fat feeding induced glucose intolerance. Daily s.c. injections of exendin-4 (50 nmol/kg bw) for 12 days restored glycaemic control and significantly (P
LanguageEnglish
Pages70-76
JournalRegulatory Peptides
Volume153
Issue number1-3
DOIs
Publication statusPublished - Feb 2009

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Hypoglycemic Agents
Incretins
Fats
Glucagon-Like Peptide 1
Glucose Intolerance
Meals
Homeostasis
Therapeutics
Hormones
Glucose
Injections
Enzymes
exenatide
gastric inhibitory polypeptide receptor

Cite this

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Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice. / Irwin, Nigel; Hunter, Kerry; Frizzell, Norma; Flatt, Peter.

In: Regulatory Peptides, Vol. 153, No. 1-3, 02.2009, p. 70-76.

Research output: Contribution to journalArticle

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