Antibiotic treatment of exacerbation of chronic airways infection

S Pattison, E Johnston, David Gibson, D Pappin, JS Elborn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p
Original languageEnglish
Title of host publicationJournal of Cystic Fibrosis
PublisherElsevier
PagesS71
Number of pages1
Volume11
Edition1
DOIs
Publication statusPublished - Jun 2012
Event35th European Cystic Fibrosis Conference - Dublin, Ireland
Duration: 1 Jun 2012 → …

Conference

Conference35th European Cystic Fibrosis Conference
Period1/06/12 → …

Keywords

  • Antibiotics
  • Cystic Fibrosis
  • proteomics
  • SILAC

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  • Cite this

    Pattison, S., Johnston, E., Gibson, D., Pappin, D., & Elborn, JS. (2012). Antibiotic treatment of exacerbation of chronic airways infection. In Journal of Cystic Fibrosis (1 ed., Vol. 11, pp. S71). Elsevier. https://doi.org/10.1016/S1569-1993(12)60226-4