Antibiotic treatment of exacerbation of chronic airways infection

S Pattison, E Johnston, David Gibson, D Pappin, JS Elborn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p
LanguageEnglish
Title of host publicationUnknown Host Publication
PublisherElsevier
Number of pages1
Publication statusPublished - Jun 2012
Event35th European Cystic Fibrosis Conference - Dublin, Ireland
Duration: 1 Jun 2012 → …

Conference

Conference35th European Cystic Fibrosis Conference
Period1/06/12 → …

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Anti-Bacterial Agents
Infection
Lung
Proteome
Sputum
Pseudomonas aeruginosa
Proteins
Therapeutics
Biomarkers

Keywords

  • Antibiotics
  • Cystic Fibrosis
  • proteomics
  • SILAC

Cite this

Pattison, S., Johnston, E., Gibson, D., Pappin, D., & Elborn, JS. (2012). Antibiotic treatment of exacerbation of chronic airways infection. In Unknown Host Publication Elsevier.
Pattison, S ; Johnston, E ; Gibson, David ; Pappin, D ; Elborn, JS. / Antibiotic treatment of exacerbation of chronic airways infection. Unknown Host Publication. Elsevier, 2012.
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Pattison, S, Johnston, E, Gibson, D, Pappin, D & Elborn, JS 2012, Antibiotic treatment of exacerbation of chronic airways infection. in Unknown Host Publication. Elsevier, 35th European Cystic Fibrosis Conference, 1/06/12.

Antibiotic treatment of exacerbation of chronic airways infection. / Pattison, S; Johnston, E; Gibson, David; Pappin, D; Elborn, JS.

Unknown Host Publication. Elsevier, 2012.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Antibiotic treatment of exacerbation of chronic airways infection

AU - Pattison, S

AU - Johnston, E

AU - Gibson, David

AU - Pappin, D

AU - Elborn, JS

PY - 2012/6

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N2 - Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p

AB - Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p

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KW - Cystic Fibrosis

KW - proteomics

KW - SILAC

M3 - Conference contribution

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Pattison S, Johnston E, Gibson D, Pappin D, Elborn JS. Antibiotic treatment of exacerbation of chronic airways infection. In Unknown Host Publication. Elsevier. 2012