Antibiotic treatment of exacerbation of chronic airways infection

S Pattison; E Johnston; David Gibson; D Pappin; JS Elborn

doi:10.1016/S1569-1993(12)60226-4

Antibiotic treatment of exacerbation of chronic airways infection

S Pattison, E Johnston, David Gibson, D Pappin, JS Elborn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Abstract

Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p

Original language	English
Title of host publication	Journal of Cystic Fibrosis
Publisher	Elsevier
Pages	S71
Number of pages	1
Volume	11
Edition	1
DOIs	https://doi.org/10.1016/S1569-1993(12)60226-4
Publication status	Published (in print/issue) - Jun 2012
Event	35th European Cystic Fibrosis Conference - Dublin, Ireland Duration: 1 Jun 2012 → …

Conference

Conference	35th European Cystic Fibrosis Conference
Period	1/06/12 → …

Keywords

Antibiotics
Cystic Fibrosis
proteomics
SILAC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1569-1993(12)60226-4

5 Pattison et al 2012Final published version, 68.7 KB

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title = "Antibiotic treatment of exacerbation of chronic airways infection",

abstract = "Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p",

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T1 - Antibiotic treatment of exacerbation of chronic airways infection

AU - Pattison, S

AU - Johnston, E

AU - Gibson, David

AU - Pappin, D

AU - Elborn, JS

PY - 2012/6

Y1 - 2012/6

N2 - Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p

AB - Objectives: Repeated cycles of pulmonary exacerbation of chronic infection causetissue damage and progressive drop in lung function for CF patients so makingeffective treatment and prevention strategies imperative. Our study aims to betterunderstand the response to antibiotics and identify biomarker targets suitable forimproved therapeutic or preventative treatments.Methods: Multidimensional LC-MS/MS and relative quantitation was employed toinvestigate the changes in sputum cellular proteome following antibiotic treatmentin 12 CF patients chronically infected with Pseudomonas aeruginosa.Conclusions: 1989 human proteins were identified in total. 37 proteins out ofthe 318 detected in >80% samples were differentially expressed (p

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KW - Cystic Fibrosis

KW - proteomics

KW - SILAC

U2 - 10.1016/S1569-1993(12)60226-4

DO - 10.1016/S1569-1993(12)60226-4

M3 - Conference contribution

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SP - S71

BT - Journal of Cystic Fibrosis

PB - Elsevier

T2 - 35th European Cystic Fibrosis Conference

Y2 - 1 June 2012

ER -

Antibiotic treatment of exacerbation of chronic airways infection

Abstract

Conference

Keywords

UN SDGs

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