Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens.

Claire Valotteau, Ibrahim Banat, Christopher Mitchell, Helen Lydon, Roger Marchant, Florence Babonneau, Claire-Marie Pradier, Niki Baccile, Vincent Humblot

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties.We show that they can be used to develop biocidal monolayers against Listeria ivanovii, aGram-positive bacterium. The present work points out the dependence between thesurface density and the antibacterial activity of grafted sophorolipids. It also emphasizesthe broad spectrum of activity of these coatings, demonstrating their potential againstboth Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis,Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonasaeruginosa and Salmonella typhymurium). After exposure to sophorolipids grafted ontogold, all these bacterial strains show a significant reduction in viability resulting frommembrane damage as evidenced by fluorescent labelling and SEM-FEG analysis.
LanguageEnglish
Pages325-334
JournalColloids and Surfaces B: Biointerfaces
Volume157
Early online date2 Jun 2017
DOIs
Publication statusE-pub ahead of print - 2 Jun 2017

Fingerprint

Listeria
Staphylococcus epidermidis
Streptococcus pyogenes
Glycolipids
Salmonella
Gold
Escherichia coli
Bacteria

Keywords

  • Biosurfactant
  • sophorolipid
  • gold
  • antibacterial

Cite this

Valotteau, Claire ; Banat, Ibrahim ; Mitchell, Christopher ; Lydon, Helen ; Marchant, Roger ; Babonneau, Florence ; Pradier, Claire-Marie ; Baccile, Niki ; Humblot, Vincent. / Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens. In: Colloids and Surfaces B: Biointerfaces. 2017 ; Vol. 157. pp. 325-334.
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Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens. / Valotteau, Claire; Banat, Ibrahim; Mitchell, Christopher; Lydon, Helen; Marchant, Roger; Babonneau, Florence; Pradier, Claire-Marie; Baccile, Niki; Humblot, Vincent.

In: Colloids and Surfaces B: Biointerfaces, Vol. 157, 02.06.2017, p. 325-334.

Research output: Contribution to journalArticle

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T1 - Antibacterial properties of sophorolipid-modified gold surfaces against Gram positive and Gram negative pathogens.

AU - Valotteau, Claire

AU - Banat, Ibrahim

AU - Mitchell, Christopher

AU - Lydon, Helen

AU - Marchant, Roger

AU - Babonneau, Florence

AU - Pradier, Claire-Marie

AU - Baccile, Niki

AU - Humblot, Vincent

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AB - Sophorolipids are bioderived glycolipids displaying interesting antimicrobial properties.We show that they can be used to develop biocidal monolayers against Listeria ivanovii, aGram-positive bacterium. The present work points out the dependence between thesurface density and the antibacterial activity of grafted sophorolipids. It also emphasizesthe broad spectrum of activity of these coatings, demonstrating their potential againstboth Gram-positive strains (Enteroccocus faecalis, Staphylococcus epidermidis,Streptococcus pyogenes) and Gram-negative strains (Escherichia coli, Pseudomonasaeruginosa and Salmonella typhymurium). After exposure to sophorolipids grafted ontogold, all these bacterial strains show a significant reduction in viability resulting frommembrane damage as evidenced by fluorescent labelling and SEM-FEG analysis.

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KW - gold

KW - antibacterial

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