Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)

Y Maeda, A Loughrey, J.A.P Earle, B. Cherie Millar, J Rao, A Kearns, O McConville, C.E Goldsmith, P.J Rooney, James Dooley, Colm Lowery, William J Snelling, M.A.S McMahon, David McDowell, J.E Moore

Research output: Contribution to journalArticle

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has now been described globally, as a clinically significant pathogen, particularly associated with skin and soft tissue infections, including abscesses, cellulitis and furunculosis. The recent emergence of CA-MRSA combined with its predominant presentation associated with skin and soft tissue infection, the previous literature indicating honey as an effective treatment of healthcare-associated HA-MRSA-related wound infection, as well as honey's ease of topical application, make the current study timely and of interest to healthcare practitioners involved with wound management. Although previous studies have examined the antimicrobial activity of honey against HA-MRSA, such data are limited regarding the activity of honey against this emerging type of MRSA. CA-MRSA (n=6 isolates), was examined for its susceptibility to natural honey (n=3 honey produced from bees in Northern Ireland and one commercial French honey). Results demonstrated that all honey was able to reduce the cultural count of all CA-MRSA from approximately 10(6) colony-forming units (cfus) (mean = 6.46 log10 cfu/g) to none detectable within 24h of co-culture of separate CA-MRSA organisms individually with all four-honey types examined. Subsequent non-selective enrichment of honey demonstrated that inoculated honey remained positive for CA-MRSA until 72h postinoculation, after which point no culturable organisms could be detected. This study demonstrated that, in vitro, these natural products had an antimicrobial activity against the CA-MRSA organisms tested. Further studies are now required to demonstrate if this antimicrobial activity has any clinical application.
LanguageEnglish
Pages77-82
Number of pages6
JournalComplementary Therapies in Clinical Practice
Volume14
DOIs
Publication statusPublished - 2007

Fingerprint

Honey
Methicillin-Resistant Staphylococcus aureus
Soft Tissue Infections
Stem Cells
Furunculosis
Delivery of Health Care
Northern Ireland
Skin
Cellulitis
Bees
Wound Infection
Coculture Techniques
Biological Products
Abscess

Cite this

Maeda, Y ; Loughrey, A ; Earle, J.A.P ; Millar, B. Cherie ; Rao, J ; Kearns, A ; McConville, O ; Goldsmith, C.E ; Rooney, P.J ; Dooley, James ; Lowery, Colm ; Snelling, William J ; McMahon, M.A.S ; McDowell, David ; Moore, J.E. / Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). In: Complementary Therapies in Clinical Practice. 2007 ; Vol. 14. pp. 77-82.
@article{9e7b31370e634a37a16230332f1f8347,
title = "Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)",
abstract = "Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has now been described globally, as a clinically significant pathogen, particularly associated with skin and soft tissue infections, including abscesses, cellulitis and furunculosis. The recent emergence of CA-MRSA combined with its predominant presentation associated with skin and soft tissue infection, the previous literature indicating honey as an effective treatment of healthcare-associated HA-MRSA-related wound infection, as well as honey's ease of topical application, make the current study timely and of interest to healthcare practitioners involved with wound management. Although previous studies have examined the antimicrobial activity of honey against HA-MRSA, such data are limited regarding the activity of honey against this emerging type of MRSA. CA-MRSA (n=6 isolates), was examined for its susceptibility to natural honey (n=3 honey produced from bees in Northern Ireland and one commercial French honey). Results demonstrated that all honey was able to reduce the cultural count of all CA-MRSA from approximately 10(6) colony-forming units (cfus) (mean = 6.46 log10 cfu/g) to none detectable within 24h of co-culture of separate CA-MRSA organisms individually with all four-honey types examined. Subsequent non-selective enrichment of honey demonstrated that inoculated honey remained positive for CA-MRSA until 72h postinoculation, after which point no culturable organisms could be detected. This study demonstrated that, in vitro, these natural products had an antimicrobial activity against the CA-MRSA organisms tested. Further studies are now required to demonstrate if this antimicrobial activity has any clinical application.",
author = "Y Maeda and A Loughrey and J.A.P Earle and Millar, {B. Cherie} and J Rao and A Kearns and O McConville and C.E Goldsmith and P.J Rooney and James Dooley and Colm Lowery and Snelling, {William J} and M.A.S McMahon and David McDowell and J.E Moore",
year = "2007",
doi = "10.1016/j.cfcp.2007.11.04",
language = "English",
volume = "14",
pages = "77--82",
journal = "Complementary Therapies in Clinical Practice",
issn = "1744-3881",
publisher = "Elsevier",

}

Maeda, Y, Loughrey, A, Earle, JAP, Millar, BC, Rao, J, Kearns, A, McConville, O, Goldsmith, CE, Rooney, PJ, Dooley, J, Lowery, C, Snelling, WJ, McMahon, MAS, McDowell, D & Moore, JE 2007, 'Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)', Complementary Therapies in Clinical Practice, vol. 14, pp. 77-82. https://doi.org/10.1016/j.cfcp.2007.11.04

Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). / Maeda, Y; Loughrey, A; Earle, J.A.P; Millar, B. Cherie; Rao, J; Kearns, A; McConville, O; Goldsmith, C.E; Rooney, P.J; Dooley, James; Lowery, Colm; Snelling, William J; McMahon, M.A.S; McDowell, David; Moore, J.E.

In: Complementary Therapies in Clinical Practice, Vol. 14, 2007, p. 77-82.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)

AU - Maeda, Y

AU - Loughrey, A

AU - Earle, J.A.P

AU - Millar, B. Cherie

AU - Rao, J

AU - Kearns, A

AU - McConville, O

AU - Goldsmith, C.E

AU - Rooney, P.J

AU - Dooley, James

AU - Lowery, Colm

AU - Snelling, William J

AU - McMahon, M.A.S

AU - McDowell, David

AU - Moore, J.E

PY - 2007

Y1 - 2007

N2 - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has now been described globally, as a clinically significant pathogen, particularly associated with skin and soft tissue infections, including abscesses, cellulitis and furunculosis. The recent emergence of CA-MRSA combined with its predominant presentation associated with skin and soft tissue infection, the previous literature indicating honey as an effective treatment of healthcare-associated HA-MRSA-related wound infection, as well as honey's ease of topical application, make the current study timely and of interest to healthcare practitioners involved with wound management. Although previous studies have examined the antimicrobial activity of honey against HA-MRSA, such data are limited regarding the activity of honey against this emerging type of MRSA. CA-MRSA (n=6 isolates), was examined for its susceptibility to natural honey (n=3 honey produced from bees in Northern Ireland and one commercial French honey). Results demonstrated that all honey was able to reduce the cultural count of all CA-MRSA from approximately 10(6) colony-forming units (cfus) (mean = 6.46 log10 cfu/g) to none detectable within 24h of co-culture of separate CA-MRSA organisms individually with all four-honey types examined. Subsequent non-selective enrichment of honey demonstrated that inoculated honey remained positive for CA-MRSA until 72h postinoculation, after which point no culturable organisms could be detected. This study demonstrated that, in vitro, these natural products had an antimicrobial activity against the CA-MRSA organisms tested. Further studies are now required to demonstrate if this antimicrobial activity has any clinical application.

AB - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has now been described globally, as a clinically significant pathogen, particularly associated with skin and soft tissue infections, including abscesses, cellulitis and furunculosis. The recent emergence of CA-MRSA combined with its predominant presentation associated with skin and soft tissue infection, the previous literature indicating honey as an effective treatment of healthcare-associated HA-MRSA-related wound infection, as well as honey's ease of topical application, make the current study timely and of interest to healthcare practitioners involved with wound management. Although previous studies have examined the antimicrobial activity of honey against HA-MRSA, such data are limited regarding the activity of honey against this emerging type of MRSA. CA-MRSA (n=6 isolates), was examined for its susceptibility to natural honey (n=3 honey produced from bees in Northern Ireland and one commercial French honey). Results demonstrated that all honey was able to reduce the cultural count of all CA-MRSA from approximately 10(6) colony-forming units (cfus) (mean = 6.46 log10 cfu/g) to none detectable within 24h of co-culture of separate CA-MRSA organisms individually with all four-honey types examined. Subsequent non-selective enrichment of honey demonstrated that inoculated honey remained positive for CA-MRSA until 72h postinoculation, after which point no culturable organisms could be detected. This study demonstrated that, in vitro, these natural products had an antimicrobial activity against the CA-MRSA organisms tested. Further studies are now required to demonstrate if this antimicrobial activity has any clinical application.

U2 - 10.1016/j.cfcp.2007.11.04

DO - 10.1016/j.cfcp.2007.11.04

M3 - Article

VL - 14

SP - 77

EP - 82

JO - Complementary Therapies in Clinical Practice

T2 - Complementary Therapies in Clinical Practice

JF - Complementary Therapies in Clinical Practice

SN - 1744-3881

ER -