Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

Mazhar Salim Al Zoubi; Wesam Al Khateeb; Musab El-oqlah; Mu’ath Migdady; Manl Issam Abu Al-arja; Muna Bzour; Ahmad El-oqlah; Samah Almubarak; Mahmoud A Al-qudah; Khalid Al-batayneh; Michella Mkhael; Ahmed Elokda; Prawej Ansari; Jma Hannan; Mohamed M Nasef; Murtaza Tambuwala; Hamid Bakshi

doi:10.31557/APJCP.2022.23.1.161

Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

Mazhar Salim Al Zoubi
, Wesam Al Khateeb
, Musab El-oqlah
, Mu’ath Migdady
, Manl Issam Abu Al-arja
, Muna Bzour
, Ahmad El-oqlah
, Samah Almubarak
, Mahmoud A Al-qudah
, Khalid Al-batayneh
, Michella Mkhael
, Ahmed Elokda
, Prawej Ansari
, Jma Hannan
, Mohamed M Nasef
, Murtaza Tambuwala
, Hamid Bakshi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

935 Downloads (Pure)

Abstract

AIM: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. METHODS: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. RESULTS: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. CONCLUSION: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.

Original language	English
Pages (from-to)	161-169
Number of pages	9
Journal	Asian Pacific Journal of Cancer Prevention
Volume	23
Issue number	1
DOIs	https://doi.org/10.31557/APJCP.2022.23.1.161
Publication status	Published (in print/issue) - 27 Jan 2022

Bibliographical note

Funding Information:
Research and Graduate Studies at Yarmouk University for the financial support to complete this project. And Special thanks to Dr. Bahaa Al-Trad for his generous support in his laboratory. And we thank Mr. Adel Rababah for his help in the production of our figures.

Publisher Copyright:
© This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.

Funding

Funding Information: Research and Graduate Studies at Yarmouk University for the financial support to complete this project. And Special thanks to Dr. Bahaa Al-Trad for his generous support in his laboratory. And we thank Mr. Adel Rababah for his help in the production of our figures. Publisher Copyright: © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-angiogenesis
Anti-proliferation
M. peregrina
anti-inflammation
benign prostatic hyperplasia
Benign prostatic hyperplasia
Anti-inflammation

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10.31557/APJCP.2022.23.1.161Licence: CC BY-NC

APJCP_Volume 23_Issue 1_Pages 161-169Final published version, 1.07 MBLicence: CC BY-NC

http://journal.waocp.org/article_89948.htmlLicence: CC BY-NC

Cite this

Al Zoubi, M. S., Al Khateeb, W., El-oqlah, M., Migdady, M., Abu Al-arja, M. I., Bzour, M., El-oqlah, A., Almubarak, S., Al-qudah, M. A., Al-batayneh, K., Mkhael, M., Elokda, A., Ansari, P., Hannan, J., Nasef, M. M., Tambuwala, M., & Bakshi, H. (2022). Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats. Asian Pacific Journal of Cancer Prevention, 23(1), 161-169. https://doi.org/10.31557/APJCP.2022.23.1.161

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title = "Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats",

abstract = "AIM: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. METHODS: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. RESULTS: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. CONCLUSION: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.",

keywords = "Anti-angiogenesis, Anti-proliferation, M. peregrina, anti-inflammation, benign prostatic hyperplasia, Benign prostatic hyperplasia, Anti-inflammation",

author = "\{Al Zoubi\}, \{Mazhar Salim\} and \{Al Khateeb\}, Wesam and Musab El-oqlah and Mu{\textquoteright}ath Migdady and \{Abu Al-arja\}, \{Manl Issam\} and Muna Bzour and Ahmad El-oqlah and Samah Almubarak and Al-qudah, \{Mahmoud A\} and Khalid Al-batayneh and Michella Mkhael and Ahmed Elokda and Prawej Ansari and Jma Hannan and Nasef, \{Mohamed M\} and Murtaza Tambuwala and Hamid Bakshi",

note = "Funding Information: Research and Graduate Studies at Yarmouk University for the financial support to complete this project. And Special thanks to Dr. Bahaa Al-Trad for his generous support in his laboratory. And we thank Mr. Adel Rababah for his help in the production of our figures. Publisher Copyright: {\textcopyright} This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.",

year = "2022",

month = jan,

day = "27",

doi = "10.31557/APJCP.2022.23.1.161",

language = "English",

volume = "23",

pages = "161--169",

journal = "Asian Pacific Journal of Cancer Prevention",

issn = "2476-762X",

number = "1",

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Al Zoubi, MS, Al Khateeb, W, El-oqlah, M, Migdady, M, Abu Al-arja, MI, Bzour, M, El-oqlah, A, Almubarak, S, Al-qudah, MA, Al-batayneh, K, Mkhael, M, Elokda, A, Ansari, P, Hannan, J, Nasef, MM, Tambuwala, M & Bakshi, H 2022, 'Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats', Asian Pacific Journal of Cancer Prevention, vol. 23, no. 1, pp. 161-169. https://doi.org/10.31557/APJCP.2022.23.1.161

Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats. / Al Zoubi, Mazhar Salim; Al Khateeb, Wesam; El-oqlah, Musab et al.
In: Asian Pacific Journal of Cancer Prevention, Vol. 23, No. 1, 27.01.2022, p. 161-169.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

AU - Al Zoubi, Mazhar Salim

AU - Al Khateeb, Wesam

AU - El-oqlah, Musab

AU - Migdady, Mu’ath

AU - Abu Al-arja, Manl Issam

AU - Bzour, Muna

AU - El-oqlah, Ahmad

AU - Almubarak, Samah

AU - Al-qudah, Mahmoud A

AU - Al-batayneh, Khalid

AU - Mkhael, Michella

AU - Elokda, Ahmed

AU - Ansari, Prawej

AU - Hannan, Jma

AU - Nasef, Mohamed M

AU - Tambuwala, Murtaza

AU - Bakshi, Hamid

N1 - Funding Information: Research and Graduate Studies at Yarmouk University for the financial support to complete this project. And Special thanks to Dr. Bahaa Al-Trad for his generous support in his laboratory. And we thank Mr. Adel Rababah for his help in the production of our figures. Publisher Copyright: © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.

PY - 2022/1/27

Y1 - 2022/1/27

N2 - AIM: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. METHODS: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. RESULTS: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. CONCLUSION: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.

AB - AIM: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. METHODS: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. RESULTS: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. CONCLUSION: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.

KW - Anti-angiogenesis

KW - Anti-proliferation

KW - M. peregrina

KW - anti-inflammation

KW - benign prostatic hyperplasia

KW - Benign prostatic hyperplasia

KW - Anti-inflammation

UR - https://www.scopus.com/pages/publications/85123815954

U2 - 10.31557/APJCP.2022.23.1.161

DO - 10.31557/APJCP.2022.23.1.161

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SN - 2476-762X

VL - 23

SP - 161

EP - 169

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

IS - 1

ER -

Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Molecular analysis of the effects of crocin on acute myeloid leukaemia, pancreatic and colon cancer

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Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Student theses

Molecular analysis of the effects of crocin on acute myeloid leukaemia, pancreatic and colon cancer

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