Abstract
AIM: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. METHODS: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. RESULTS: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. CONCLUSION: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.
Original language | English |
---|---|
Pages (from-to) | 161-169 |
Number of pages | 9 |
Journal | Asian Pacific Journal of Cancer Prevention |
Volume | 23 |
Issue number | 1 |
DOIs | |
Publication status | Published (in print/issue) - 27 Jan 2022 |
Bibliographical note
Funding Information:Research and Graduate Studies at Yarmouk University for the financial support to complete this project. And Special thanks to Dr. Bahaa Al-Trad for his generous support in his laboratory. And we thank Mr. Adel Rababah for his help in the production of our figures.
Publisher Copyright:
© This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.
Keywords
- Anti-angiogenesis
- Anti-proliferation
- M. peregrina
- anti-inflammation
- benign prostatic hyperplasia
- Benign prostatic hyperplasia
- Anti-inflammation