Anti-proliferative, Anti-angiogenic and Anti-inflammatory Effects of Moringa peregrina Leaf Extracts on Testosterone- Induced Benign Prostatic Hyperplasia in Rats

Mazhar Salim Al Zoubi, Wesam Al Khateeb, Musab El-oqlah, Mu’ath Migdady, Manl Issam Abu Al-arja, Muna Bzour, Ahmad El-oqlah, Samah Almubarak, Mahmoud A Al-qudah, Khalid Al-batayneh, Michella Mkhael, Ahmed Elokda, Prawej Ansari, Jma Hannan, Mohamed M Nasef, Murtaza Tambuwala, Hamid Bakshi

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Abstract

AIM: To investigate the potential anti-inflammatory and biochemical effects of Moringa peregrina leaf extracts on testosterone-induced benign prostatic hyperplasia (BPH) in rats. METHODS: Six groups of rats (each group included 5 rats) were included in this study. The groups included: 1) the control group, 2) the testosterone-induced BPH group, 3) with 50 mg/kg bwt (bodyweight) oil-treated BPH, 4) with 100 mg/kg bwt. oil-treated BPH, 5) with 500mg/kg bwt. ethanol treated BPH and 6) with 1,000 mg/kg bwt. aqueous treated BPH group. Biochemical markers were measured to evaluate the effect of M. peregrina leaf extracts. RESULTS: Our results showed a significant improvement in the thickness of epithelial cells of the BPH glandular tissues when treated with different M. peregrina extracts (p < 0.05). In addition, M. peregrina extracts showed anti-inflammatory, anti-proliferative and anti-angiogenesis effects on the BPH tissues by reduction of IL-6, PCNA and VEGF-A, respectively. CONCLUSION: Our preclinical study concluded that M. peregrina leaf extracts showed a significant effect on BPH by reducing inflammation, proliferation, and angiogenic processes with no signs of toxicity.

Original languageEnglish
Pages (from-to)161-169
Number of pages9
JournalAsian Pacific Journal of Cancer Prevention
Volume23
Issue number1
DOIs
Publication statusPublished - 27 Jan 2022

Bibliographical note

Funding Information:
Research and Graduate Studies at Yarmouk University for the financial support to complete this project. And Special thanks to Dr. Bahaa Al-Trad for his generous support in his laboratory. And we thank Mr. Adel Rababah for his help in the production of our figures.

Publisher Copyright:
© This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.

Keywords

  • Anti-angiogenesis
  • Anti-proliferation
  • M. peregrina
  • anti-inflammation
  • benign prostatic hyperplasia

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