Anomalous Wavefront Aberrations Reduce Optical Quality In Down Syndrome

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Purpose:Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Structural and functional differences in the optics of DS eyes are reported in the literature. Studies report a thinner, steeper cornea and a thinner crystalline lens and, functionally, a degrading influence of DS optics on resolution acuity. The present study further investigates optical quality in DS by comparing wavefront aberrations in DS and control eyes. Methods: Participants were 38 children with DS (6-16 years) and 209 age-matched controls. Monochromatic higher order aberrations (HOAs) were measured following cycloplegia (1% Cyclopentolate) using Shack-Hartmann aberrometry (IRX3, Imagine Eyes). HOAs were analysed over a fixed 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was assessed using the Strehl ratio (calculated by the IRX3 software) over 3, 4 and 5mm pupil diameters. Results: HOAs were measured successfully from 73% of the DS group and 97% of controls. Right eye data were analysed. Mean root mean square of total HOAs differed significantly between groups (0.33µm±0.09 DS; 0.29µm±0.12 controls) (Mann Whitney z=-2.34, p=0.02). Mean spherical equivalent did not correlate significantly with the degree of HOAs in either DS or control groups ( p>0.05). Significant differences were found between the DS and control group for trefoil sine term Z(3,-3), horizontal coma Z(3,1), spherical aberration Z(4,0), quadrafoil cosine term Z(4,4), Z(5,-3), Z(5,-1), Z(5,1) and Z(6,4). The wavefront patterns produced a significantly lower Strehl ratio in the DS group compared to controls over all pupil diameters with the greatest difference seen at 3mm (0.27±0.14 DS; 0.43±0.16 controls) (Mann Whitney z=4.84, p
LanguageEnglish
Title of host publicationUnknown Host Publication
Number of pages1
Volume52
Publication statusPublished - 22 Apr 2011
EventAssociation for Research in Vision & Ophthalmology - United States of America
Duration: 22 Apr 2011 → …

Conference

ConferenceAssociation for Research in Vision & Ophthalmology
Period22/04/11 → …

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Down Syndrome
Pupil
Control Groups
Aberrometry
Cyclopentolate
Eye Abnormalities
Pupil Disorders
Crystalline Lens
Coma
Cornea
Software

Cite this

@inproceedings{0f6f042760f74e8fad06f9cff1f77541,
title = "Anomalous Wavefront Aberrations Reduce Optical Quality In Down Syndrome",
abstract = "Purpose:Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Structural and functional differences in the optics of DS eyes are reported in the literature. Studies report a thinner, steeper cornea and a thinner crystalline lens and, functionally, a degrading influence of DS optics on resolution acuity. The present study further investigates optical quality in DS by comparing wavefront aberrations in DS and control eyes. Methods: Participants were 38 children with DS (6-16 years) and 209 age-matched controls. Monochromatic higher order aberrations (HOAs) were measured following cycloplegia (1{\%} Cyclopentolate) using Shack-Hartmann aberrometry (IRX3, Imagine Eyes). HOAs were analysed over a fixed 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was assessed using the Strehl ratio (calculated by the IRX3 software) over 3, 4 and 5mm pupil diameters. Results: HOAs were measured successfully from 73{\%} of the DS group and 97{\%} of controls. Right eye data were analysed. Mean root mean square of total HOAs differed significantly between groups (0.33µm±0.09 DS; 0.29µm±0.12 controls) (Mann Whitney z=-2.34, p=0.02). Mean spherical equivalent did not correlate significantly with the degree of HOAs in either DS or control groups ( p>0.05). Significant differences were found between the DS and control group for trefoil sine term Z(3,-3), horizontal coma Z(3,1), spherical aberration Z(4,0), quadrafoil cosine term Z(4,4), Z(5,-3), Z(5,-1), Z(5,1) and Z(6,4). The wavefront patterns produced a significantly lower Strehl ratio in the DS group compared to controls over all pupil diameters with the greatest difference seen at 3mm (0.27±0.14 DS; 0.43±0.16 controls) (Mann Whitney z=4.84, p",
author = "McCullough, {Sara J} and Julie-Anne Little and Saunders, {Kathryn J}",
year = "2011",
month = "4",
day = "22",
language = "English",
volume = "52",
booktitle = "Unknown Host Publication",

}

McCullough, SJ, Little, J-A & Saunders, KJ 2011, Anomalous Wavefront Aberrations Reduce Optical Quality In Down Syndrome. in Unknown Host Publication. vol. 52, Association for Research in Vision & Ophthalmology, 22/04/11.

Anomalous Wavefront Aberrations Reduce Optical Quality In Down Syndrome. / McCullough, Sara J; Little, Julie-Anne; Saunders, Kathryn J.

Unknown Host Publication. Vol. 52 2011.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Anomalous Wavefront Aberrations Reduce Optical Quality In Down Syndrome

AU - McCullough, Sara J

AU - Little, Julie-Anne

AU - Saunders, Kathryn J

PY - 2011/4/22

Y1 - 2011/4/22

N2 - Purpose:Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Structural and functional differences in the optics of DS eyes are reported in the literature. Studies report a thinner, steeper cornea and a thinner crystalline lens and, functionally, a degrading influence of DS optics on resolution acuity. The present study further investigates optical quality in DS by comparing wavefront aberrations in DS and control eyes. Methods: Participants were 38 children with DS (6-16 years) and 209 age-matched controls. Monochromatic higher order aberrations (HOAs) were measured following cycloplegia (1% Cyclopentolate) using Shack-Hartmann aberrometry (IRX3, Imagine Eyes). HOAs were analysed over a fixed 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was assessed using the Strehl ratio (calculated by the IRX3 software) over 3, 4 and 5mm pupil diameters. Results: HOAs were measured successfully from 73% of the DS group and 97% of controls. Right eye data were analysed. Mean root mean square of total HOAs differed significantly between groups (0.33µm±0.09 DS; 0.29µm±0.12 controls) (Mann Whitney z=-2.34, p=0.02). Mean spherical equivalent did not correlate significantly with the degree of HOAs in either DS or control groups ( p>0.05). Significant differences were found between the DS and control group for trefoil sine term Z(3,-3), horizontal coma Z(3,1), spherical aberration Z(4,0), quadrafoil cosine term Z(4,4), Z(5,-3), Z(5,-1), Z(5,1) and Z(6,4). The wavefront patterns produced a significantly lower Strehl ratio in the DS group compared to controls over all pupil diameters with the greatest difference seen at 3mm (0.27±0.14 DS; 0.43±0.16 controls) (Mann Whitney z=4.84, p

AB - Purpose:Down syndrome (DS) is associated with ocular abnormalities and reduced visual function. Structural and functional differences in the optics of DS eyes are reported in the literature. Studies report a thinner, steeper cornea and a thinner crystalline lens and, functionally, a degrading influence of DS optics on resolution acuity. The present study further investigates optical quality in DS by comparing wavefront aberrations in DS and control eyes. Methods: Participants were 38 children with DS (6-16 years) and 209 age-matched controls. Monochromatic higher order aberrations (HOAs) were measured following cycloplegia (1% Cyclopentolate) using Shack-Hartmann aberrometry (IRX3, Imagine Eyes). HOAs were analysed over a fixed 5mm pupil using Zernike polynomials from 3rd to 6th order. Optical quality was assessed using the Strehl ratio (calculated by the IRX3 software) over 3, 4 and 5mm pupil diameters. Results: HOAs were measured successfully from 73% of the DS group and 97% of controls. Right eye data were analysed. Mean root mean square of total HOAs differed significantly between groups (0.33µm±0.09 DS; 0.29µm±0.12 controls) (Mann Whitney z=-2.34, p=0.02). Mean spherical equivalent did not correlate significantly with the degree of HOAs in either DS or control groups ( p>0.05). Significant differences were found between the DS and control group for trefoil sine term Z(3,-3), horizontal coma Z(3,1), spherical aberration Z(4,0), quadrafoil cosine term Z(4,4), Z(5,-3), Z(5,-1), Z(5,1) and Z(6,4). The wavefront patterns produced a significantly lower Strehl ratio in the DS group compared to controls over all pupil diameters with the greatest difference seen at 3mm (0.27±0.14 DS; 0.43±0.16 controls) (Mann Whitney z=4.84, p

M3 - Conference contribution

VL - 52

BT - Unknown Host Publication

ER -