Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women

F Kee, C Morrison, O Poirier, E McCrum, C Mallet, V Nicaud, D McMaster, J Dallongeville, JC Fruchart, AE Evans

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Background Findings relating an association between an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene and myocardial infarction (MI) have been mixed. While other loci, such as the angiotensin II type-I receptor (AT(1)R), may modulate risk, few studies have adequately documented the risk in women. We aimed to study whether the findings in respect of ACE and AT(1)R in UK men were borne out in women. Methods Cases of MI (305 women, 391 men) in Belfast and Glasgow have been compared to controls (291 women, 356 men). These new samples augment the original men (200 cases, 181 controls) included from Belfast in the ECTIM study. Results Among men, the odds ratio for MI for ACE (DD vs. ID + II) was 1.03 (0.79, 1.34) and among women, 0.69 (0.47, 1.01). This heterogeneity between the risks in men and women was significant in Glasgow (P = 0.02). Among men and women the odds ratio for MI for AT(1)R (CC vs. AC + AA) was 1.02 (0.71, 1.47). There was a small gradient in risk, such that the odds ratio for DD genotype was 0.86 (0.63, 1.17) among subjects homozygous for the common AT(1)R alelle (AA): 0.94 (0.67, 1.30) among heterozygotes and 1.21 (0.53, 2.77) among CC subjects; but this interaction was not statistically significant. Conclusions Some of the contradictory findings concerning the ACE polymorphism and the risk of MI may be due to heterogeneity in the risk between men and women. The AT(1)R(1196) polymorphism is not an independent risk factor for MI in either sex.
    LanguageEnglish
    Pages1076-1082
    JournalEuropean Journal of Clinical Investigation
    Volume30
    Issue number12
    Publication statusPublished - Dec 2000

    Fingerprint

    Angiotensin I
    Angiotensin Receptors
    Peptidyl-Dipeptidase A
    Myocardial Infarction
    Odds Ratio
    Heterozygote
    Genotype

    Cite this

    Kee, F., Morrison, C., Poirier, O., McCrum, E., Mallet, C., Nicaud, V., ... Evans, AE. (2000). Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women. European Journal of Clinical Investigation, 30(12), 1076-1082.
    Kee, F ; Morrison, C ; Poirier, O ; McCrum, E ; Mallet, C ; Nicaud, V ; McMaster, D ; Dallongeville, J ; Fruchart, JC ; Evans, AE. / Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women. In: European Journal of Clinical Investigation. 2000 ; Vol. 30, No. 12. pp. 1076-1082.
    @article{0c667fbe5801412894f146fcebfc671d,
    title = "Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women",
    abstract = "Background Findings relating an association between an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene and myocardial infarction (MI) have been mixed. While other loci, such as the angiotensin II type-I receptor (AT(1)R), may modulate risk, few studies have adequately documented the risk in women. We aimed to study whether the findings in respect of ACE and AT(1)R in UK men were borne out in women. Methods Cases of MI (305 women, 391 men) in Belfast and Glasgow have been compared to controls (291 women, 356 men). These new samples augment the original men (200 cases, 181 controls) included from Belfast in the ECTIM study. Results Among men, the odds ratio for MI for ACE (DD vs. ID + II) was 1.03 (0.79, 1.34) and among women, 0.69 (0.47, 1.01). This heterogeneity between the risks in men and women was significant in Glasgow (P = 0.02). Among men and women the odds ratio for MI for AT(1)R (CC vs. AC + AA) was 1.02 (0.71, 1.47). There was a small gradient in risk, such that the odds ratio for DD genotype was 0.86 (0.63, 1.17) among subjects homozygous for the common AT(1)R alelle (AA): 0.94 (0.67, 1.30) among heterozygotes and 1.21 (0.53, 2.77) among CC subjects; but this interaction was not statistically significant. Conclusions Some of the contradictory findings concerning the ACE polymorphism and the risk of MI may be due to heterogeneity in the risk between men and women. The AT(1)R(1196) polymorphism is not an independent risk factor for MI in either sex.",
    author = "F Kee and C Morrison and O Poirier and E McCrum and C Mallet and V Nicaud and D McMaster and J Dallongeville and JC Fruchart and AE Evans",
    year = "2000",
    month = "12",
    language = "English",
    volume = "30",
    pages = "1076--1082",
    journal = "European Journal of Clinical Investigation",
    issn = "0014-2972",
    number = "12",

    }

    Kee, F, Morrison, C, Poirier, O, McCrum, E, Mallet, C, Nicaud, V, McMaster, D, Dallongeville, J, Fruchart, JC & Evans, AE 2000, 'Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women', European Journal of Clinical Investigation, vol. 30, no. 12, pp. 1076-1082.

    Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women. / Kee, F; Morrison, C; Poirier, O; McCrum, E; Mallet, C; Nicaud, V; McMaster, D; Dallongeville, J; Fruchart, JC; Evans, AE.

    In: European Journal of Clinical Investigation, Vol. 30, No. 12, 12.2000, p. 1076-1082.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women

    AU - Kee, F

    AU - Morrison, C

    AU - Poirier, O

    AU - McCrum, E

    AU - Mallet, C

    AU - Nicaud, V

    AU - McMaster, D

    AU - Dallongeville, J

    AU - Fruchart, JC

    AU - Evans, AE

    PY - 2000/12

    Y1 - 2000/12

    N2 - Background Findings relating an association between an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene and myocardial infarction (MI) have been mixed. While other loci, such as the angiotensin II type-I receptor (AT(1)R), may modulate risk, few studies have adequately documented the risk in women. We aimed to study whether the findings in respect of ACE and AT(1)R in UK men were borne out in women. Methods Cases of MI (305 women, 391 men) in Belfast and Glasgow have been compared to controls (291 women, 356 men). These new samples augment the original men (200 cases, 181 controls) included from Belfast in the ECTIM study. Results Among men, the odds ratio for MI for ACE (DD vs. ID + II) was 1.03 (0.79, 1.34) and among women, 0.69 (0.47, 1.01). This heterogeneity between the risks in men and women was significant in Glasgow (P = 0.02). Among men and women the odds ratio for MI for AT(1)R (CC vs. AC + AA) was 1.02 (0.71, 1.47). There was a small gradient in risk, such that the odds ratio for DD genotype was 0.86 (0.63, 1.17) among subjects homozygous for the common AT(1)R alelle (AA): 0.94 (0.67, 1.30) among heterozygotes and 1.21 (0.53, 2.77) among CC subjects; but this interaction was not statistically significant. Conclusions Some of the contradictory findings concerning the ACE polymorphism and the risk of MI may be due to heterogeneity in the risk between men and women. The AT(1)R(1196) polymorphism is not an independent risk factor for MI in either sex.

    AB - Background Findings relating an association between an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene and myocardial infarction (MI) have been mixed. While other loci, such as the angiotensin II type-I receptor (AT(1)R), may modulate risk, few studies have adequately documented the risk in women. We aimed to study whether the findings in respect of ACE and AT(1)R in UK men were borne out in women. Methods Cases of MI (305 women, 391 men) in Belfast and Glasgow have been compared to controls (291 women, 356 men). These new samples augment the original men (200 cases, 181 controls) included from Belfast in the ECTIM study. Results Among men, the odds ratio for MI for ACE (DD vs. ID + II) was 1.03 (0.79, 1.34) and among women, 0.69 (0.47, 1.01). This heterogeneity between the risks in men and women was significant in Glasgow (P = 0.02). Among men and women the odds ratio for MI for AT(1)R (CC vs. AC + AA) was 1.02 (0.71, 1.47). There was a small gradient in risk, such that the odds ratio for DD genotype was 0.86 (0.63, 1.17) among subjects homozygous for the common AT(1)R alelle (AA): 0.94 (0.67, 1.30) among heterozygotes and 1.21 (0.53, 2.77) among CC subjects; but this interaction was not statistically significant. Conclusions Some of the contradictory findings concerning the ACE polymorphism and the risk of MI may be due to heterogeneity in the risk between men and women. The AT(1)R(1196) polymorphism is not an independent risk factor for MI in either sex.

    M3 - Article

    VL - 30

    SP - 1076

    EP - 1082

    JO - European Journal of Clinical Investigation

    T2 - European Journal of Clinical Investigation

    JF - European Journal of Clinical Investigation

    SN - 0014-2972

    IS - 12

    ER -