Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women

F Kee, C Morrison, O Poirier, E McCrum, C Mallet, V Nicaud, D McMaster, J Dallongeville, JC Fruchart, AE Evans

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    Abstract

    Background Findings relating an association between an insertion/deletion polymorphism of the angiotensin converting enzyme (ACE) gene and myocardial infarction (MI) have been mixed. While other loci, such as the angiotensin II type-I receptor (AT(1)R), may modulate risk, few studies have adequately documented the risk in women. We aimed to study whether the findings in respect of ACE and AT(1)R in UK men were borne out in women. Methods Cases of MI (305 women, 391 men) in Belfast and Glasgow have been compared to controls (291 women, 356 men). These new samples augment the original men (200 cases, 181 controls) included from Belfast in the ECTIM study. Results Among men, the odds ratio for MI for ACE (DD vs. ID + II) was 1.03 (0.79, 1.34) and among women, 0.69 (0.47, 1.01). This heterogeneity between the risks in men and women was significant in Glasgow (P = 0.02). Among men and women the odds ratio for MI for AT(1)R (CC vs. AC + AA) was 1.02 (0.71, 1.47). There was a small gradient in risk, such that the odds ratio for DD genotype was 0.86 (0.63, 1.17) among subjects homozygous for the common AT(1)R alelle (AA): 0.94 (0.67, 1.30) among heterozygotes and 1.21 (0.53, 2.77) among CC subjects; but this interaction was not statistically significant. Conclusions Some of the contradictory findings concerning the ACE polymorphism and the risk of MI may be due to heterogeneity in the risk between men and women. The AT(1)R(1196) polymorphism is not an independent risk factor for MI in either sex.
    Original languageEnglish
    Pages (from-to)1076-1082
    JournalEuropean Journal of Clinical Investigation
    Volume30
    Issue number12
    Publication statusPublished - Dec 2000

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