An overview of three biocatalysts of pharmaceutical importance synthesized by microbial cultures

Divakar Dahiya, Poonam Singh - Nee Nigam

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
3 Downloads (Pure)

Abstract

This article includes a general overview of the published research on a topic relevant to biomedical sciences research, pharma-industries and healthcare sector. We have presented a concise information on three enzymes. These biomolecules have been investigated for their biocatalytic activities beneficial in the detection of drugs and their metabolites present in micro-quantities in samples of blood, urine, and other body fluids, such as salicylate hydroxylase, and dihydrofolate reductase. Some enzymes are useful in biotransformation of compounds to convert them in an optically active form, such as lipase. The information presented in this article has been collected from the published studies on their catalytic function, and biosynthesis using selected microorganisms. Several diagnostic assays are currently using enzymes as effective biocatalysts to perform the detection-test. For the marketing and consumer’s convenience, pharmaceutical companies have designed biosensors and diagnostic kits by incorporating specific enzymes for rapid tests required in pathology, as well as for the quantification of certain metabolites and chemicals in pathology samples in a shorter time. For such purpose use of enzymes synthesized by selected specific microorganisms is economical.

Original languageEnglish
Pages (from-to)124-137
Number of pages14
JournalAIMS Microbiology
Volume7
Issue number2
Early online date27 Apr 2021
DOIs
Publication statusE-pub ahead of print - 27 Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 the Author(s), licensee AIMS Press.

Keywords

  • Salicylate Hydroxylase
  • Dihydrofolate reductase
  • Lipase
  • Aspirin
  • Methotrexate
  • Salicylate hydroxylase

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