An Overview of nano delivery systems for targeting RNA interference-based therapy in ulcerative colitis

Iman Alfagih, Basmah Aldosari, Bushra Alquadeib, Alanood Almurshedi, Murtaza Tambuwala

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
15 Downloads (Pure)

Abstract

Ulcerative colitis (UC) is one of the main subtypes of inflammatory bowel disease. UC has a negative effect on patients’ quality of life, and it is an important risk factor for the development of colitis-associated cancer. Patients with UC need to take medications for their entire life because no permanent cure is available. Therefore, approaches that target messenger RNA (mRNA) of proinflammatory cytokines and/or anti-inflammatory cytokines are needed to improve the safety of UC therapy and promote intestinal mucosa recovery. The major challenge facing RNA interference-based therapy is the delivery of RNA molecules to the intracellular space of target cells. Moreover, nonspecific and systemic protein expression inhibition can result in adverse effects and low therapeutic benefit. Thus, it is important to develop an efficient delivery strategy targeting the cytoplasm of target cells to avoid side effects caused by off-target protein expression inhibition. This review focuses on the most recent advances in the targeted nano delivery systems of siRNAs and mRNA that have shown in vivo efficacy.
Original languageEnglish
Pages (from-to)2904-2914
Number of pages11
JournalCurrent Pharmaceutical Design
Volume27
Issue number25
DOIs
Publication statusPublished (in print/issue) - 26 Aug 2021

Bibliographical note

Funding Information:
This research project was supported by a grant from the ?Research Center of the Female Scientific and Medical Colleges?, Deanship of Scientific Research, King Saud University, Saudi Arabia.

Funding Information:
This research project was supported by a grant from the “Research Center of the Female Scientific and Medical Colleges”, Deanship of Scientific Research, King Saud University, Saudi Arabia.

Publisher Copyright:
© 2021 Bentham Science Publishers.

Keywords

  • drug delivery system
  • colitis
  • RNA nanoparticles
  • Pharmaceutical Science
  • inflammation
  • Therapeutic
  • Nanoparticles
  • Surface functionalization
  • RNA interference
  • Targeted delivery
  • Inflammation
  • Ulcerative colitis
  • Intestinal Mucosa
  • Humans
  • RNA Interference
  • Colitis, Ulcerative/drug therapy
  • Quality of Life
  • RNAi Therapeutics

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