An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry and Some of Its Applications

Mark W Duncan, David Gibson, Ryan Walsh, Afsham Massod, Hicham Benabdelkamel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Matrix-assisted laser desorption/ionization time-of-flight (TOF) mass spectrometry (MS) is a powerful tool for both the qualitative and quantitative analysis of wide array of analytes. MALDI-TOF MS is simple, both in design and practice, and offers the advantages that analysis times are very short, the mass range is virtually unlimited, and sensitivity is high. This chapter describes the theory and practice of MALDI and illustrates the utility of approach by reviewing its commonapplications.
Original languageEnglish
Title of host publicationDetection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism, NATO Science for Peace and Security Series A: Chemistry and Biology
Place of PublicationDordrecht, Germany
Pages69-81
DOIs
Publication statusPublished - 18 Sep 2014

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Duncan, M. W., Gibson, D., Walsh, R., Massod, A., & Benabdelkamel, H. (2014). An Overview of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry and Some of Its Applications. In Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism, NATO Science for Peace and Security Series A: Chemistry and Biology (pp. 69-81). Dordrecht, Germany. https://doi.org/10.1007/978-94-017-9238-7_5