An evaluation of the IOLMaster 700 and its agreement with the IOLMaster v3 in children

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Abstract

Purpose
To evaluate the repeatability and reproducibility of the swept-source optical coherence tomographer Zeiss IOLMaster 700 and compare its outputs with those obtained using partial coherence interferometry (Zeiss IOLMaster v3) in a healthy, paediatric population.

Methods
This is a cross-sectional, observational study. Examiner 1 took two sets of biometric measurements (axial length [AL], mean corneal radius of curvature [Kmean], anterior chamber depth [ACD] and lens thickness [LT]) using the IOLMaster 700, and one set of measurements (AL, Kmean and ACD) using the IOLMaster v3. Examiner 2 took one full set of measurements using the IOLMaster 700. Mean differences and 95% limits of agreement (LOA) were calculated, and Bland and Altman plots used to explore repeatability and reproducibility of the IOLMaster 700 alongside establishing its agreement with the IOLMaster v3.

Results
Mean participant age was 7.52 ± 0.58 years. Repeatability analyses demonstrated small mean differences and narrow 95% LOA for AL (0.001, −0.013 to 0.015 mm), Kmean (0.002, −0.020 to 0.024 mm), ACD (−0.003, −0.031 to 0.024 mm) and LT (0.001, −0.024 to 0.026 mm), respectively. Similarly, small mean differences and narrow 95% LOA established excellent reproducibility (AL 0.001, −0.016 to 0.018 mm; Kmean −0.001, −0.027 to 0.025 mm; ACD −0.010, −0.041 to 0.021 mm; LT 0.002, −0.016 to 0.020 mm). The IOLMaster 700 and IOLMaster v3 demonstrated good agreement with small mean differences and narrow 95% LOA (AL 0.009, −0.034 to 0.052 mm; Kmean 0.016, −0.013 to 0.044 mm; ACD 0.134, 0.055 to 0.212 mm).

Conclusions
When used within a paediatric population, these data demonstrate the IOLMaster 700 to be highly repeatable and reproducible for measures of AL, Kmean, ACD and LT. There is excellent inter-instrument agreement between the IOLMaster 700 and IOLMaster v3 for measures of AL and Kmean. ACD measurements show weaker agreement. These data will be useful when considering reports from population-based studies of refractive error and clinical myopia research.
Original languageEnglish
Pages (from-to)48-58
Number of pages11
JournalOphthalmic and Physiological Optics
Volume42
Issue number1
Early online date10 Nov 2021
DOIs
Publication statusPublished - 5 Dec 2021

Bibliographical note

Funding Information:
This work was supported by a Department for the Economy (Northern Ireland) PhD studentship. The authors would like to thank the subjects that participated within this study.

Publisher Copyright:
© 2021 The Authors Ophthalmic and Physiological Optics © 2021 The College of Optometrists

Keywords

  • Sensory Systems
  • Optometry
  • Ophthalmology
  • repeatability
  • agreement
  • IOLMaster
  • reproducibility
  • myopia
  • axial length

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