An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry

Bernadette Doherty, Virginia Rodriguez, Julian Leslie, Stephen McClean, W. Franklin Smyth

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21 Citations (Scopus)

Abstract

A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright (C) 2007 John Wiley & Sons, Ltd.
LanguageEnglish
Pages2031-2038
JournalRapid Communications in Mass Spectrometry
Volume21
Issue number13
DOIs
Publication statusPublished - 2007

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Electrospray ionization
Psychotropic Drugs
Liquid chromatography
Metabolites
Mass spectrometry
Trimipramine
Ions
Sertraline
Paroxetine
Risperidone
Pharmaceutical Preparations
Liquids
mirtazapine

Cite this

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title = "An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry",
abstract = "A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright (C) 2007 John Wiley & Sons, Ltd.",
author = "Bernadette Doherty and Virginia Rodriguez and Julian Leslie and Stephen McClean and Smyth, {W. Franklin}",
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TY - JOUR

T1 - An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry

AU - Doherty, Bernadette

AU - Rodriguez, Virginia

AU - Leslie, Julian

AU - McClean, Stephen

AU - Smyth, W. Franklin

PY - 2007

Y1 - 2007

N2 - A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright (C) 2007 John Wiley & Sons, Ltd.

AB - A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright (C) 2007 John Wiley & Sons, Ltd.

U2 - 10.1002/rcm.3060

DO - 10.1002/rcm.3060

M3 - Article

VL - 21

SP - 2031

EP - 2038

JO - Rapid Communications in Mass Spectrometry

T2 - Rapid Communications in Mass Spectrometry

JF - Rapid Communications in Mass Spectrometry

SN - 0951-4198

IS - 13

ER -