An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry

Bernadette Doherty, Virginia Rodriguez, Julian Leslie, Stephen McClean, W. Franklin Smyth

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A tandem mass spectrometric investigation of the collision-induced dissociation of five commonly prescribed psychoactive pharmaceuticals, risperidone, sertraline, paroxetine, trimipramine, and mirtazapine, and their metabolites has been carried out. Quadrupole ion trap mass spectrometry was employed to generate tandem mass spectrometric (MS/MS) data of the compounds under investigation and structural assignments of product ions were supported by quadrupole time-of-flight mass spectrometry. These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information. Copyright (C) 2007 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)2031-2038
JournalRapid Communications in Mass Spectrometry
Volume21
Issue number13
DOIs
Publication statusPublished - 2007

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