An Early Stage Researcher’s Primer on Systems Medicine Terminology

Massimiliano Zanin, Nadim Atiya, Jose Basilio, Jan Baumbach, Arriel Benis, Chandan Behera, Magda Bucholc, Filippo Castiglione, Ioanna Chouvarda, Blandine Comte, Tien-Tuan Dao, Xuemei Ding, Estelle Pujos-Guillot, Nenad Filipovic, David Finn, David H. Glass, Nissim Harel, Tomas Iesmantas, Ilinka Ivanoska, Alok JoshiKarim Boudjeltia, Badr Kaoui, Daman Kaur, Liam Maguire, Paula McClean, Niamh McCombe, Joao Luis de Miranda, Mihnea Moisescu, Francesco Pappalardo, Annikka Polster, Girijesh Prasad, Damjana Rozman, Ioan Sacala, Jose Sanchez Bornot, Johannes Schmid, Trevor Sharp, Jordi Solé-Casals, Vojtěch Spiwok, George Spyrou, Egils Stalidzans, Blaz Stres, Tijana Sustersic, Ioannis Symeonidis, Paolo Tieri, Stephen Todd, Kristel van Steen, Milena Veneva, Da-Hui Wang, Haiying / HY Wang, Hui Wang, Steven Watterson, Su Yang, Xin Zou, KongFatt Wong-Lin, Harald Schmidt

Research output: Contribution to journalReview articlepeer-review

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Abstract

Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic. [Abstract copyright: © Massimiliano Zanin et al., 2021; Published by Mary Ann Liebert, Inc.]
Original languageEnglish
Pages (from-to)2-50
JournalNetwork and Systems Medicine
Volume4
Issue number1
Early online date25 Feb 2021
DOIs
Publication statusE-pub ahead of print - 25 Feb 2021

Keywords

  • Genetics
  • Graphs and Networks
  • machine learning
  • medicine
  • Systems medicine
  • multi-scale modelling
  • multi-scale data science

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