An audit of antimicrobial treatment of lower respiratory and urinary tract infections in a hospital setting

H. Maripuu, M.A. Aldeyab, M.P. Kearney, J.C. McElnay, G. Conlon, F.A. Magee, M.G. Scott

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objectives To audit the quality of treatment of lower respiratory tract infections (LRTIs) and urinary tract infections (UTIs) and to identify targets for antibiotic stewardship. Methods The audit involved collecting data on admitted patients, who were diagnosed with LRTIs or UTIs and subsequently received antibiotic treatment (January 2009-April 2009). Key findings The percentage adherence rate for hospital antibiotic policy was 68.6% (24/35). Documentation of the CURB-65 score was found in 80% (16/20) of the patients' clinical notes, for which 46.2% (6/13) of patients were treated according to their CURB- 65 score. The percentages of delayed and missed doses for all antibiotics were 21.7% (254/1171) and 8.6% (101/1171), respectively. The percentage of patients switched from intravenous to oral antibiotics in accordance with the policy was 58.5% (31/53). The mean length of stay for patients switched in line with the guidelines was 6.9 days (range: 2-18 days) compared with 13.2 days (range: 4-28 days) for patients treated with intravenous antibiotics >24 h after the intravenous to oral switch criteria were fulfilled; this equates to on average an extra 6.3 days of hospitalisation (p=0.01). Conclusions The study identified a number of targets for quality improvement including adherence to antibiotic policy, documentation of the CURB-65 score in patients' notes and treating patients accordingly, addressing the issue of missed and delayed doses, and maintaining adherence to the hospital intravenous-to-oral antibiotic switch policy. The findings suggest that the quality of antibiotic prescribing could be improved by measuring and addressing such performance indicators.
Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalEuropean Journal of Hospital Pharmacy
Issue number3
Publication statusPublished (in print/issue) - 2014

Bibliographical note

Cited By :4

Export Date: 15 September 2018

Correspondence Address: Scott, M. G.; Head of Pharmacy and Medicines Management, Pharmacy and Medicines Management Centre, Antrim Area Hospital, 45 Bush Road, Antrim BT41 2RL, United Kingdom; email:

Chemicals/CAS: amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; amoxicillin plus clavulanic acid, 74469-00-4, 79198-29-1; aztreonam, 78110-38-0; clarithromycin, 81103-11-9; doxycycline, 10592-13-9, 17086-28-1, 564-25-0, 94088-85-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; metronidazole, 39322-38-8, 443-48-1; teicoplanin, 61036-62-2, 61036-64-4

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  • amoxicillin
  • amoxicillin plus clavulanic acid
  • aztreonam
  • clarithromycin
  • doxycycline
  • gentamicin
  • metronidazole
  • piperacillin plus tazobactam
  • teicoplanin
  • antiinfective agent
  • adolescent
  • adult
  • aged
  • antimicrobial therapy
  • article
  • aspiration pneumonia
  • chronic obstructive lung disease
  • community acquired pneumonia
  • CURB 65 Score
  • female
  • health care policy
  • hospital acquired pneumonia
  • hospital management
  • hospitalization
  • human
  • lower respiratory tract infection
  • major clinical study
  • male
  • medical audit
  • prospective study
  • quality control
  • scoring system
  • sepsis
  • teaching hospital
  • United Kingdom
  • urinary tract infection
  • Article
  • assessment of humans
  • clinical practice
  • coronary artery disease
  • CURB 65
  • drug administration route
  • health care cost
  • length of stay
  • middle aged
  • mortality
  • protocol compliance
  • respiratory tract infection
  • young adult


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