Alleviation of diabetic nephropathy by zinc oxide nanoparticles in streptozotocin‐induced type 1 diabetes in rats

Ghada Alomari, Bahaa Al‐trad, Salehhuddin Hamdan, Alaa A. A. Aljabali, Mazhar Salim Al Zoubi, Khalid Al‐batanyeh, Janti Qar, Gregory J. Eaton, Almuthanna K. Alkaraki, Walhan Alshaer, Saja Haifawi, Khairunadwa Jemon, Dinesh Kumar Chellappan, Kamal Dua, Murtaza M. Tambuwala

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Abstract

This study examines the effect of nanoparticles with zinc oxides (ZnONPs) on diabetic nephropathy, which is the primary cause of mortality for diabetic patients with end‐stage renal disease. Diabetes in adult male rats was induced via intraperitoneal injection of streptozotocin. ZnONPs were intraperitoneally administered to diabetic rats daily for 7 weeks. Diabetes was associated with increases in blood glucose level, 24‐h urinary albumin excretion rate, glomerular basement membrane thickness, renal oxidative stress markers, and renal mRNA or protein expression of transforming growth factor‐β1, fibronectin, collagen‐IV, tumour necrosis factor‐α and vascular endothelial growth factor‐A. Moreover, the expression of nephrin and podocin, and the mRNA expression of matrix metalloproteinase‐9 were decreased in the diabetic group. These changes were not detected in the control group and were significantly prevented by ZnONP treatment. These results provide evidence that ZnONPs ameliorate the renal damage induced in a diabetic rat model of nephropathy through improving renal functionality; inhibiting renal fibrosis, oxidative stress, inflammation and abnormal angiogenesis; and delaying the development of podocyte injury. The present findings may help design the clinical application of ZnONPs for protection against the development of diabetic nephropathy.
Original languageEnglish
Number of pages11
JournalIET Nanobiotechnology
Early online date10 Mar 2021
DOIs
Publication statusE-pub ahead of print - 10 Mar 2021

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