Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 193-199 |
| Journal | International Journal of Pharmaceutics |
| Volume | 444 |
| Early online date | 5 Jan 2013 |
| DOIs | |
| Publication status | E-pub ahead of print - 5 Jan 2013 |
Keywords
- Beclometasone dipropionate
- Liposome
- Nebulizer
- Niosome
- Proniosome
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Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology. / Elhissi, Abdelbary; Hidayat, Kanar; Phoenix, David; Mwesigwa, Enosh; Crean, StJohn; Ahmed, Waqar; Faheem, Ahmed; Taylor, Kevin M.G.
In: International Journal of Pharmaceutics, Vol. 444, 05.01.2013, p. 193-199.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology
AU - Elhissi, Abdelbary
AU - Hidayat, Kanar
AU - Phoenix, David
AU - Mwesigwa, Enosh
AU - Crean, StJohn
AU - Ahmed, Waqar
AU - Faheem, Ahmed
AU - Taylor, Kevin M.G.
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PY - 2013/1/5
Y1 - 2013/1/5
N2 - The aerosol properties of niosomes were studied using Aeroneb Pro and Omron MicroAir vibrating-mesh nebulizers and Pari LC Sprint air-jet nebulizer. Proniosomes were prepared by coating sucrose particles with Span 60 (sorbitan monostearate), cholesterol and beclometasone dipropionate (BDP) (1:1:0.1). Nano-sized niosomes were produced by manual shaking of the proniosomes in deionized water followed by sonication (median size 236 nm). The entrapment of BDP in proniosome-derived niosomes was higher than that in conventional thin film-made niosomes, being 36.4% and 27.5% respectively. All nebulizers generated aerosols with very high drug output, which was 83.6% using the Aeroneb Pro, 85.5% using the Pari and 72.4% using the Omron. The median droplet size was 3.32 m, 3.06 m and 4.86 m for the Aeroneb Pro, Pari and Omron nebulizers respectively and the “fine particle fraction” (FPF) of BDP was respectively 68.7%, 76.2% and 42.1%. The predicted extrathoracic deposition, based on size distribution of nebulized droplets was negligible for all devices, suggesting all of them are potentially suitable for pulmonary delivery of niosomes. The predicted drug deposition in the alveolar region was low using the Omron (3.2%), but greater using the Aeroneb Pro (17.4%) and the Pari (20.5%). Overall, noisome- BDP aerosols with high drug output and FPF can be generated from proniosomes and delivered using vibrating-mesh or air-jet nebulizers.
AB - The aerosol properties of niosomes were studied using Aeroneb Pro and Omron MicroAir vibrating-mesh nebulizers and Pari LC Sprint air-jet nebulizer. Proniosomes were prepared by coating sucrose particles with Span 60 (sorbitan monostearate), cholesterol and beclometasone dipropionate (BDP) (1:1:0.1). Nano-sized niosomes were produced by manual shaking of the proniosomes in deionized water followed by sonication (median size 236 nm). The entrapment of BDP in proniosome-derived niosomes was higher than that in conventional thin film-made niosomes, being 36.4% and 27.5% respectively. All nebulizers generated aerosols with very high drug output, which was 83.6% using the Aeroneb Pro, 85.5% using the Pari and 72.4% using the Omron. The median droplet size was 3.32 m, 3.06 m and 4.86 m for the Aeroneb Pro, Pari and Omron nebulizers respectively and the “fine particle fraction” (FPF) of BDP was respectively 68.7%, 76.2% and 42.1%. The predicted extrathoracic deposition, based on size distribution of nebulized droplets was negligible for all devices, suggesting all of them are potentially suitable for pulmonary delivery of niosomes. The predicted drug deposition in the alveolar region was low using the Omron (3.2%), but greater using the Aeroneb Pro (17.4%) and the Pari (20.5%). Overall, noisome- BDP aerosols with high drug output and FPF can be generated from proniosomes and delivered using vibrating-mesh or air-jet nebulizers.
KW - Beclometasone dipropionate
KW - Liposome
KW - Nebulizer
KW - Niosome
KW - Proniosome
U2 - 10.1016/j.ijpharm.2012.12.040
DO - 10.1016/j.ijpharm.2012.12.040
M3 - Article
VL - 444
SP - 193
EP - 199
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
ER -