Abstract
Original language | English |
---|---|
Pages (from-to) | 193-199 |
Journal | International Journal of Pharmaceutics |
Volume | 444 |
Early online date | 5 Jan 2013 |
DOIs | |
Publication status | E-pub ahead of print - 5 Jan 2013 |
Keywords
- Beclometasone dipropionate
- Liposome
- Nebulizer
- Niosome
- Proniosome
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Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology. / Elhissi, Abdelbary; Hidayat, Kanar; Phoenix, David; Mwesigwa, Enosh; Crean, StJohn; Ahmed, Waqar; Faheem, Ahmed; Taylor, Kevin M.G.
In: International Journal of Pharmaceutics, Vol. 444, 05.01.2013, p. 193-199.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology
AU - Elhissi, Abdelbary
AU - Hidayat, Kanar
AU - Phoenix, David
AU - Mwesigwa, Enosh
AU - Crean, StJohn
AU - Ahmed, Waqar
AU - Faheem, Ahmed
AU - Taylor, Kevin M.G.
N1 - Reference text: Albasarah, Y.Y., Somavarapu, S., Stapleton, P., Taylor, K.M., 2010. Chitosan-coated antifungal formulations for nebulisation. J. Pharm. Pharmacol. 62, 821–828. Abd-Elbary, A., El-Laithy, H.M., Tadros, M.I., 2008. Sucrose stearate-based pronisomes-derived niosomes for the nebulisable delivery of cromolyn sodium. Int. J. Pharm. 357, 189–198. Batavia, R., Taylor, K.M.G., Craig, D.Q.M., Thomas, M., 2001. The measurement of beclomethasone dipropionate entrapment in liposomes: a comparison of a microscope and an HPLC method. Int. J. Pharm. 212, 109–119. Bridges, P.A., Taylor, K.M.G., 2000. The effects of freeze-drying on the stability of liposomes to jet nebulization. J. Pharm. Pharmacol. 53, 393–398. Clark, A.R., 1995. The use of laser diffraction for the evaluation of the aerosol clouds generated by medical nebulizers. Int. J. Pharm. 115, 69–78. Clay, M.M., Pavia, D., Newman, S.P., Lennard-Jones, T., Clarke, S.W., 1983. Assessment of jet nebulisers for lung aerosol therapy. Lancet 2, 592–594. Crommelin, D.J., 1984. Influence of lipid composition and ionic strength on the physical stability of liposomes. J. Pharm. Sci. 73, 1559–1563. Crowe, L.M., Crowe, J.H., 1988. Trehalose and dry dipalmitoylphosphatidylcholine revisted. Biochim. Biophys. Acta 946, 193–201. Dahlbنck, M., 1994. Behavior of nebulizing solutions and suspensions. J. Aerosol Med. 7 (Suppl. 1), S13–S18. Darwis, Y., Kellaway, I.W., 2001. Nebulisation of rehydrated freeze-dried beclomethasone dipropionate liposomes. Int. J. Pharm. 215, 113–121. Desai, T.R., Finlay, W.H., 2002. Nebulization of niosomal all-trans-retinoic acid: an inexpensive alternative to conventional liposomes. Int. J. Pharm. 241, 311–317. Dhand, R., 2002. Nebulizers that use a vibrating mesh or plate with multiple apertures to generate aerosol. Respir. Care 47, 1406–1416. Elhissi, A.M.A., Taylor, K.M.G., 2005. Delivery of liposomes generated from proliposomes using air-jet, ultrasonic and vibrating-mesh nebulisers. J. Drug Del. Sci. Technol. 15, 261–265. Elhissi, A.M.A., Karnam, K.K., Danesh, M.R., Gill, H.S., Taylor, K.M.G., 2006a. Formulations generated from ethanol-based proliposomes for delivery via medical nebulizers. J. Pharm. Pharmacol. 58, 887–894. Elhissi, A.M.A., O’Neill, M.A.A., Roberts, S.A., Taylor, K.M.G., 2006b. A calorimetric study of dimyristoylphosphatidylcholine phase transitions and steroid–liposome interactions for liposomes prepared by thin film and proliposome methods. Int. J. Pharm. 320, 124–130. Elhissi, A.M., Faizi, M., Naji, W.F., Gill, H.S., Taylor, K.M., 2007. Physical stability and aerosol properties of liposomes delivered using an air-jet nebulizer and a novel micropump device with large mesh apertures. Int. J. Pharm. 334, 62–70. Elhissi, A., Gill, H., Ahmed, W., Taylor, K., 2011a. Vibrating-mesh nebulization of liposomes generated using an ethanol-based proliposome technology. J. Liposome Res. 21, 173–180. Elhissi, A.M.A., O’Neill, M., Ahmed, W., Taylor, K.M.G., 2011b. High sensitivity differential scanning calorimetry for measurement of steroid entrapment in nebulised liposomes generated from proliposomes. Micro Nano Lett. 6, 694–697. Ghazanfari, T., Elhissi, A.M., Ding, Z., Taylor, K.M., 2007. The influence of fluid physicochemical properties on vibrating-mesh nebulization. Int. J. Pharm. 339, 103–111. Hao, Y-M., Li, K., 2011. Entrapment and release difference resulting from hydrogen bonding interactions in niosomes. Int. J. Pharm. 403, 245–253. Heyder, J., 1982. Particle transport onto human airway surfaces. Eur. J. Respir. Dis. Suppl. 119, 29–50. Hu, C., Rhodes, D.G., 1999. Proniosomes: a novel drug carrier preparation. Int. J. Pharm. 206, 110–122. Junyaprasert, V.B., Teeranachaideekul, V., Supaperm, T., 2008. Effect of charged and non-ionic membrane additives on physicochemical properties and stability of niosomes. AAPS Pharm. SciTech. 9, 851–859. Kellaway, I.W., Farr, S.J., 1990. Liposomes as drug delivery systems to the lung. Adv. Drug Deliv. Rev. 5, 149–161. Kwong, W.T.J., Ho, S.L., Coates, A.L., 2000. Comparison of nebulized particle size distribution with Malvern laser diffraction analyzer versus Andersen Cascade Impactor and Low-flow Marple Personal Cascade Impactor. J. Aerosol Med. 13, 303–314. Lange, C.F., Hancock, R.E.W., Samuel, J., Finlay, W.H., 2001. In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide. J. Pharm. Sci. 90, 1647–1657. Mosharraf, M., Taylor, K.M., Craig, D.Q., 1995. Effect of calcium ions on the surface charge and aggregation of phosphatidylcholine liposomes. J. Drug Target. 2, 541–545. Nasr, M., Nawaz, S., Elhissi, A.M.A., 2012. Amphotericin B lipid nanoemulsion aerosols for targeting peripheral respiratory airways via nebulization. Int. J. Pharm. 436, 611–616. Newman, S., Gee-Turner, A., 2005. The Omron MicroAir vibrating mesh technology nebuliser, a 21st century approach to inhalation therapy. Drug Deliv. Syst. Sci. 4, 45–48. Niven, R.W., Speer, M., Schreier, H., 1991. Nebulization of liposomes. II. The effects of size and modeling of solute release profiles. Pharm. Res. 8, 217–221. None, L.V., Grimbert, D., Becquemin, M.H., Boissinot, E., Le Pape, A., Lemarié, E., Diot, P., 2001. Validation of laser diffraction method as a substitute for cascade impaction in the European Project for a nebulizer standard. J. Aerosol. Med. 14, 107–114. O’Callaghan, C., Barry, P.W., 1997. The science of nebulised drug delivery. Thorax 52 (Suppl. 2), S31–S44. Ofir, E., Oren, Y., Adin, A., 2007. Electroflocculation: the effect of zeta-potential on particle size. Desalination 204, 33–38. Payne, N.I., Timmins, P., Ambrose, C.V., Ward, M.D., Ridgway, F., 1986. Proliposomes: a novel solution to an old problem. J. Pharm. Sci. 75, 325–329. Puglia, C., Rizza, L., Drechsler, M., Bonina, F., 2010. Nanoemulsions as vehicles for topical administration of glycyrrhetic acid: characterization and in vitro and in vivo evaluation. Drug Deliv. 17, 123–129. Saari, M., Vidgren, M.T., Koskinen, M.O., Turjanmaa, V.M.H., Nieminen, M.M., 1999. Pulmonary distribution and clearance of two beclomethasone formulations in healthy volunteers. Int. J. Pharm. 181, 1–9. Taylor, K.M.G., Taylor, G., Kellaway, I.W., Stevens, J., 1989. The influence of liposomal encapsulation on sodium cromoglicate pharmacokinetics in man. Pharm. Res. 6, 633–636. Taylor, K.M.G., Taylor, G., Kellaway, I.W., Stevens, J., 1990. The stability of liposomes to nebulisation. Int. J. Pharm. 58, 57–61. Terzano, C., Allegra, L., Alhaique, F., Marianecci, C., Carafa, M., 2005. Nonphospholipid vesicles for pulmonary glucocorticoid delivery. Eur. J. Pharm. Biopharm. 59, 57–62. Uchegbu, I.F., Florence, A.T., 1995. Non-ionic surfactant vesicles (niosomes): physical and pharmaceutical chemistry. Adv. Colloid Interface Sci. 58, 1–55. Uchegbu, I.F., Vyas, S.P., 1998. Non ionic surfactant based vesicles (niosomes) in drug delivery. Int. J. Pharm. 172, 33–70. Van Bommel, E.M.G., Crommelin, D.J.A., 1984. Stability of doxorubicin–liposomes on storage: as an aqueous dispersion, frozen or freeze-dried. Int. J. Pharm. 22, 299–310. Van Winden, E.C.A., Talsma, H., Crommelin, D.J.A., 1998. Thermal analysis of freeze-dried liposome–carbohydrate mixtures with modulated temperature differential scanning calorimetry. J. Pharm. Sci. 87, 231–237. Van Winden, E.C.A., Crommelin, D.J.A., 1997. Long term stability of freeze-dried, lyoprotected doxorubicin liposomes. Eur. J. Pharm. Biopharm. 43, 295–307. Waldrep, J.C., Scherer, P.W., Hess, G.D., Black, M., Knight, V., 1994. Nebulized glucocorticoids in liposomes: aerosol characteristics and human dose estimates. J. Aerosol Med. 7, 135–145. Zaru, M., Mourtas, S., Klepetsanis, P., Fadda, A.M., Antimisiaris, S.G., 2007. Liposomes for drug delivery to the lungs by nebulization. Eur. J. Pharm. Biopharm. 67, 655–666.
PY - 2013/1/5
Y1 - 2013/1/5
N2 - The aerosol properties of niosomes were studied using Aeroneb Pro and Omron MicroAir vibrating-mesh nebulizers and Pari LC Sprint air-jet nebulizer. Proniosomes were prepared by coating sucrose particles with Span 60 (sorbitan monostearate), cholesterol and beclometasone dipropionate (BDP) (1:1:0.1). Nano-sized niosomes were produced by manual shaking of the proniosomes in deionized water followed by sonication (median size 236 nm). The entrapment of BDP in proniosome-derived niosomes was higher than that in conventional thin film-made niosomes, being 36.4% and 27.5% respectively. All nebulizers generated aerosols with very high drug output, which was 83.6% using the Aeroneb Pro, 85.5% using the Pari and 72.4% using the Omron. The median droplet size was 3.32 m, 3.06 m and 4.86 m for the Aeroneb Pro, Pari and Omron nebulizers respectively and the “fine particle fraction” (FPF) of BDP was respectively 68.7%, 76.2% and 42.1%. The predicted extrathoracic deposition, based on size distribution of nebulized droplets was negligible for all devices, suggesting all of them are potentially suitable for pulmonary delivery of niosomes. The predicted drug deposition in the alveolar region was low using the Omron (3.2%), but greater using the Aeroneb Pro (17.4%) and the Pari (20.5%). Overall, noisome- BDP aerosols with high drug output and FPF can be generated from proniosomes and delivered using vibrating-mesh or air-jet nebulizers.
AB - The aerosol properties of niosomes were studied using Aeroneb Pro and Omron MicroAir vibrating-mesh nebulizers and Pari LC Sprint air-jet nebulizer. Proniosomes were prepared by coating sucrose particles with Span 60 (sorbitan monostearate), cholesterol and beclometasone dipropionate (BDP) (1:1:0.1). Nano-sized niosomes were produced by manual shaking of the proniosomes in deionized water followed by sonication (median size 236 nm). The entrapment of BDP in proniosome-derived niosomes was higher than that in conventional thin film-made niosomes, being 36.4% and 27.5% respectively. All nebulizers generated aerosols with very high drug output, which was 83.6% using the Aeroneb Pro, 85.5% using the Pari and 72.4% using the Omron. The median droplet size was 3.32 m, 3.06 m and 4.86 m for the Aeroneb Pro, Pari and Omron nebulizers respectively and the “fine particle fraction” (FPF) of BDP was respectively 68.7%, 76.2% and 42.1%. The predicted extrathoracic deposition, based on size distribution of nebulized droplets was negligible for all devices, suggesting all of them are potentially suitable for pulmonary delivery of niosomes. The predicted drug deposition in the alveolar region was low using the Omron (3.2%), but greater using the Aeroneb Pro (17.4%) and the Pari (20.5%). Overall, noisome- BDP aerosols with high drug output and FPF can be generated from proniosomes and delivered using vibrating-mesh or air-jet nebulizers.
KW - Beclometasone dipropionate
KW - Liposome
KW - Nebulizer
KW - Niosome
KW - Proniosome
U2 - 10.1016/j.ijpharm.2012.12.040
DO - 10.1016/j.ijpharm.2012.12.040
M3 - Article
VL - 444
SP - 193
EP - 199
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
ER -