Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

M Andriollo-Sanchez, I Hininger-Favier, N Meunier, E Venneria, JM O'Connor, G Maiani, C Coudray, AM Roussel

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Abstract

Objective: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. Design: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. Results: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (P<0.001, P<0.001, P<0.01, respectively), but there was no significant differences in GSH levels. Conclusion: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.
LanguageEnglish
PagesS58-S62
JournalEuropean Journal of Clinical Nutrition
Volume59
Issue numberSuppl.
DOIs
Publication statusPublished - Nov 2005

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Oxidative Stress
Antioxidants
Thiobarbituric Acid Reactive Substances
France
Roma
Sulfhydryl Compounds
Italy
Superoxide Dismutase
Glutathione
Life Style

Cite this

Andriollo-Sanchez, M., Hininger-Favier, I., Meunier, N., Venneria, E., O'Connor, JM., Maiani, G., ... Roussel, AM. (2005). Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. European Journal of Clinical Nutrition, 59(Suppl.), S58-S62. https://doi.org/10.1038/sj.ejcn.1602300
Andriollo-Sanchez, M ; Hininger-Favier, I ; Meunier, N ; Venneria, E ; O'Connor, JM ; Maiani, G ; Coudray, C ; Roussel, AM. / Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. In: European Journal of Clinical Nutrition. 2005 ; Vol. 59, No. Suppl. pp. S58-S62.
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Andriollo-Sanchez, M, Hininger-Favier, I, Meunier, N, Venneria, E, O'Connor, JM, Maiani, G, Coudray, C & Roussel, AM 2005, 'Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study', European Journal of Clinical Nutrition, vol. 59, no. Suppl., pp. S58-S62. https://doi.org/10.1038/sj.ejcn.1602300

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. / Andriollo-Sanchez, M; Hininger-Favier, I; Meunier, N; Venneria, E; O'Connor, JM; Maiani, G; Coudray, C; Roussel, AM.

In: European Journal of Clinical Nutrition, Vol. 59, No. Suppl., 11.2005, p. S58-S62.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

AU - Andriollo-Sanchez, M

AU - Hininger-Favier, I

AU - Meunier, N

AU - Venneria, E

AU - O'Connor, JM

AU - Maiani, G

AU - Coudray, C

AU - Roussel, AM

PY - 2005/11

Y1 - 2005/11

N2 - Objective: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. Design: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. Results: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (P<0.001, P<0.001, P<0.01, respectively), but there was no significant differences in GSH levels. Conclusion: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.

AB - Objective: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. Design: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. Results: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (P<0.001, P<0.001, P<0.01, respectively), but there was no significant differences in GSH levels. Conclusion: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.

U2 - 10.1038/sj.ejcn.1602300

DO - 10.1038/sj.ejcn.1602300

M3 - Article

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SP - S58-S62

JO - European Journal of Clinical Nutrition

T2 - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - Suppl.

ER -