Age-dependent alteration in muscle regeneration: the critical role of tissue niche

Laura Barberi, Bianca Maria Scicchitano, Manuela De Rossi, Anne Bigot, Stephanie Duguez, Aurore Wielgosik, Claire Stewart, Jamie McPhee, Maria Conte, Marco Narici, Claudio Franceschi, Vincent Mouly, Gillian Butler-Browne, Antonio Musarò

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Although adult skeletal muscle is composed of fully differentiated fibers, it retains the capacity to regenerate in response to injury and to modify its contractile and metabolic properties in response to changing demands. The major role in the growth, remodeling and regeneration is played by satellite cells, a quiescent population of myogenic precursor cells that reside between the basal lamina and plasmalemma and that are rapidly activated in response to appropriate stimuli. However, in pathologic conditions or during aging, the complete regenerative program can be precluded by fibrotic tissue formation and resulting in functional impairment of the skeletal muscle. Our study, along with other studies, demonstrated that although the regenerative program can also be impaired by the limited proliferative capacity of satellite cells, this limit is not reached during normal aging, and it is more likely that the restricted muscle repair program in aging is presumably due to missing signals that usually render the damaged muscle a permissive environment for regenerative activity.
LanguageEnglish
Pages273-92
JournalBiogerontology
Volume14
Issue number3
Early online date12 May 2013
DOIs
Publication statusE-pub ahead of print - 12 May 2013

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Regeneration
Muscles
Skeletal Muscle
Basement Membrane
Wounds and Injuries
Growth
Population

Keywords

  • SarcopeniaMuscle regenerationSatellite cellsTissue nicheGrowth factorsStem cells

Cite this

Barberi, L., Scicchitano, B. M., De Rossi, M., Bigot, A., Duguez, S., Wielgosik, A., ... Musarò, A. (2013). Age-dependent alteration in muscle regeneration: the critical role of tissue niche. Biogerontology, 14(3), 273-92. https://doi.org/10.1007/s10522-013-9429-4
Barberi, Laura ; Scicchitano, Bianca Maria ; De Rossi, Manuela ; Bigot, Anne ; Duguez, Stephanie ; Wielgosik, Aurore ; Stewart, Claire ; McPhee, Jamie ; Conte, Maria ; Narici, Marco ; Franceschi, Claudio ; Mouly, Vincent ; Butler-Browne, Gillian ; Musarò, Antonio. / Age-dependent alteration in muscle regeneration: the critical role of tissue niche. In: Biogerontology. 2013 ; Vol. 14, No. 3. pp. 273-92.
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Barberi, L, Scicchitano, BM, De Rossi, M, Bigot, A, Duguez, S, Wielgosik, A, Stewart, C, McPhee, J, Conte, M, Narici, M, Franceschi, C, Mouly, V, Butler-Browne, G & Musarò, A 2013, 'Age-dependent alteration in muscle regeneration: the critical role of tissue niche', Biogerontology, vol. 14, no. 3, pp. 273-92. https://doi.org/10.1007/s10522-013-9429-4

Age-dependent alteration in muscle regeneration: the critical role of tissue niche. / Barberi, Laura; Scicchitano, Bianca Maria; De Rossi, Manuela; Bigot, Anne; Duguez, Stephanie; Wielgosik, Aurore; Stewart, Claire; McPhee, Jamie; Conte, Maria; Narici, Marco; Franceschi, Claudio; Mouly, Vincent; Butler-Browne, Gillian; Musarò, Antonio.

In: Biogerontology, Vol. 14, No. 3, 12.05.2013, p. 273-92.

Research output: Contribution to journalArticle

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T1 - Age-dependent alteration in muscle regeneration: the critical role of tissue niche

AU - Barberi, Laura

AU - Scicchitano, Bianca Maria

AU - De Rossi, Manuela

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AU - Wielgosik, Aurore

AU - Stewart, Claire

AU - McPhee, Jamie

AU - Conte, Maria

AU - Narici, Marco

AU - Franceschi, Claudio

AU - Mouly, Vincent

AU - Butler-Browne, Gillian

AU - Musarò, Antonio

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