Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

Isabelle Hininger-Favier, Maud Andriollo-Sanchez, Josiane Arnaud, Nathalie Meunier, Severine Bord, C Graham, Angela Polito, Giuseppe Maiani, JM O'Connor, Charles Coudray, Anne-Marie Roussel

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Abstract

Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (it 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.
LanguageEnglish
Pages569-578
JournalBRITISH JOURNAL OF NUTRITION
Volume97
Issue number3
DOIs
Publication statusPublished - Mar 2007

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lipid metabolism
long term effects
trace elements
zinc
gender
erythrocytes
lipids
middle-aged adults
placebos
volunteers
superoxide dismutase
excretion
adverse effects

Cite this

Hininger-Favier, Isabelle ; Andriollo-Sanchez, Maud ; Arnaud, Josiane ; Meunier, Nathalie ; Bord, Severine ; Graham, C ; Polito, Angela ; Maiani, Giuseppe ; O'Connor, JM ; Coudray, Charles ; Roussel, Anne-Marie. / Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study. In: BRITISH JOURNAL OF NUTRITION. 2007 ; Vol. 97, No. 3. pp. 569-578.
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author = "Isabelle Hininger-Favier and Maud Andriollo-Sanchez and Josiane Arnaud and Nathalie Meunier and Severine Bord and C Graham and Angela Polito and Giuseppe Maiani and JM O'Connor and Charles Coudray and Anne-Marie Roussel",
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Hininger-Favier, I, Andriollo-Sanchez, M, Arnaud, J, Meunier, N, Bord, S, Graham, C, Polito, A, Maiani, G, O'Connor, JM, Coudray, C & Roussel, A-M 2007, 'Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study', BRITISH JOURNAL OF NUTRITION, vol. 97, no. 3, pp. 569-578. https://doi.org/10.1017/S0007114507432974

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study. / Hininger-Favier, Isabelle; Andriollo-Sanchez, Maud; Arnaud, Josiane; Meunier, Nathalie; Bord, Severine; Graham, C; Polito, Angela; Maiani, Giuseppe; O'Connor, JM; Coudray, Charles; Roussel, Anne-Marie.

In: BRITISH JOURNAL OF NUTRITION, Vol. 97, No. 3, 03.2007, p. 569-578.

Research output: Contribution to journalArticle

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T1 - Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

AU - Hininger-Favier, Isabelle

AU - Andriollo-Sanchez, Maud

AU - Arnaud, Josiane

AU - Meunier, Nathalie

AU - Bord, Severine

AU - Graham, C

AU - Polito, Angela

AU - Maiani, Giuseppe

AU - O'Connor, JM

AU - Coudray, Charles

AU - Roussel, Anne-Marie

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N2 - Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (it 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.

AB - Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (it 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.

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DO - 10.1017/S0007114507432974

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SP - 569

EP - 578

JO - British Journal of Nutrition

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SN - 0007-1145

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