Advances in Spinal Cord Neuromodulation: The Integration of Neuroengineering, Computational Approaches, and Innovative Conceptual Frameworks

Pierre-François Pradat, David Hayon, Sophie Blancho, Pauline Neveu, Mohammed Khamaysa, Nicolas Guerout

Research output: Contribution to journalArticlepeer-review

22 Downloads (Pure)


Spinal cord stimulation (SCS) is an approved treatment for intractable pain and has recently emerged as a promising area of research for restoring function after spinal cord lesion. This review will focus on the historical evolution of this transition and the path that remains to be taken for these methods to be rigorously evaluated for application in clinical practice. New developments in SCS are being driven by advances in the understanding of spinal cord lesions at the molecular, cellular, and neuronal levels, as well as the understanding of compensatory mechanisms. Advances in neuroengineering and the computational neurosciences have enabled the development of new conceptual SCS strategies, such as spatiotemporal neuromodulation, which allows spatially selective stimulation at precise time points during anticipated movement. It has also become increasingly clear that these methods are only effective when combined with intensive rehabilitation techniques, such as new task-oriented methods and robotic aids. The emergence of innovative approaches to spinal cord neuromodulation has sparked significant enthusiasm among patients and in the media. Non-invasive methods are perceived to offer improved safety, patient acceptance, and cost-effectiveness. There is an immediate need for well-designed clinical trials involving consumer or advocacy groups to evaluate and compare the effectiveness of various treatment modalities, assess safety considerations, and establish outcome priorities.
Original languageEnglish
Article number993
Pages (from-to)1-8
Number of pages8
JournalJournal of Personalized Medicine
Issue number6
Publication statusPublished (in print/issue) - 13 Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.


  • Spinal Cord Stimulation
  • Epidural Stimulation
  • Transcutaneous Magnetic Stimulation
  • Transcutaneous Electric Stimulation
  • Non-invasive Stimulation
  • transcutaneous magnetic stimulation
  • epidural stimulation
  • transcutaneous electric stimulation
  • spinal cord stimulation
  • non-invasive stimulation


Dive into the research topics of 'Advances in Spinal Cord Neuromodulation: The Integration of Neuroengineering, Computational Approaches, and Innovative Conceptual Frameworks'. Together they form a unique fingerprint.

Cite this